Effective treatment of eczema: A Synthesis of Findings from 56 Studies

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Original Abstract of the Article

Major Research Findings

Research on eczema treatment has shown that various treatments are effective. For example, a study by 18 found that tacrolimus ointment was more effective than fluticasone ointment for facial eczema. Another study by 13 showed that oral alitretinoin was effective for severe chronic hand eczema that had not responded to topical corticosteroids. This medication could be an effective option for patients who have not responded to conventional treatments. Further, a study by 43 showed that probiotics may be an effective treatment for eczema. Probiotics are thought to improve the gut microbiome, which may reduce eczema symptoms.

Treatment Summary

18 concludes that tacrolimus ointment is effective for the treatment of facial eczema. 13 concludes that oral alitretinoin is effective for severe chronic hand eczema that has not responded to topical corticosteroids. Further, 16 concludes that ultraviolet therapy is effective for hand eczema. Finally, 43 shows that probiotics have potential as an effective treatment for eczema.

Benefits and Risks

Benefit Summary

The benefits derived from research results include the finding that tacrolimus ointment is more effective than fluticasone ointment for facial eczema. Oral alitretinoin can be an effective option for severe chronic hand eczema that has not responded to conventional treatments. Probiotics are thought to improve the gut microbiome, which may reduce eczema symptoms.

Risk Summary

The use of tacrolimus ointment can have side effects such as burning sensation at the application site. Oral alitretinoin can cause side effects such as headaches, mucocutaneous events, hyperlipidemia, and decreased free thyroxine and thyroid-stimulating hormone levels. While probiotics are generally safe, some people may experience side effects such as gastrointestinal symptoms.

Comparison Between Studies

Commonalities Between Studies

Many studies show that various approaches are effective in treating eczema. All studies emphasize that it is important to consider the risk of side effects.

Differences Between Studies

Studies differ in the targeted area of eczema, severity of eczema, and the treatments used. Therefore, it is not possible to directly compare research results. When comparing studies, it is important to consider the subjects and methods used in each study.

Consistency and Contradictions in Results

Some contradictions are observed in research on eczema treatment. For example, 18 states that tacrolimus ointment is more effective than fluticasone ointment, while other studies show no significant difference in the effects of these two treatments. Such contradictions may arise from differences in subjects and methods used in each study. Further research is needed to obtain a clearer conclusion.

Notes on Practical Application

When choosing an eczema treatment, it is important to consider not only research results but also the individual patient's symptoms and condition. Also, you need to discuss the risk of side effects with your doctor. It is dangerous to change treatments or take medications without consulting a doctor. Always follow your doctor's instructions.

Current Research Limitations

Further research is needed on eczema treatment, especially on long-term efficacy and safety. Studies are also needed to determine if a specific treatment is effective for a particular patient, taking into account individual patient constitution and genetics.

Future Research Directions

Future research directions on eczema treatment include the following.

  • Long-term efficacy and safety evaluation studies
  • Studies that consider individual patient constitution and genetics
  • Development of new treatments

Conclusion

While various treatments for eczema have been developed, the best treatment depends on the individual patient's symptoms and condition. It is important to discuss your options with your doctor and choose the best treatment for you. Eczema treatment requires perseverance. Don't give up on treatment even if the effects are not immediately noticeable.

Treatment List

Tacrolimus ointment, fluticasone ointment, oral alitretinoin, probiotics, ultraviolet therapy

Keywords
Benefit Keywords
Eczema treatment
Psoriasis treatment
1
Eczema treatment
2
Improved eczema outcome
3
Improved quality of life
4
Treats eczema
5
Reduced hand dermatitis
6
Least cost
No difference
7
Effective for asteatotic eczema
9
Effective eczema treatment
Improved quality of life
10
Improved psoriasis symptoms
11
Improved hand eczema
12
Improved CHE
13
Eczema treatment
14
Atopic eczema treatment
15
Improved hand eczema treatment
16
Atopic dermatitis treatment
17
Atopic dermatitis treatment
Effective second-line treatment
Safe and effective
18
Skin barrier repair
19
Improved Eczema Symptoms
20
Eczema treatment
21
Treatment for AE
22
Reduced flares
23
Improved quality of life
Prolonged disease-free interval
24
Eczema improvement
Safe treatment
25
Improved eczema treatment
Reduced eczema risk
Reduced risk of urban eczema
26
Treatment of atopic eczema
27
Eczema treatment
28
Dog exposure
Early daycare
Endotoxin exposure
Topical anti-inflammatories
Unpasteurized milk
29
Eczema improvement
Web-based intervention
30
Prevent atopic eczema
Treat atopic eczema
31
Eczema treatment
32
AE treatment
33
Emollients for eczema
34
Flare prevention
35
Eczema reduction
Flare prevention
Itch reduction
Quality of life improvement
36
Childhood eczema treatment
37
AE prevention
38
Atopic eczema management
39
Improved AE control
Reduced AE severity
40
Eczema treatment
LTRAs
41
Eczema treatment
H1 AH
44
Improved AE treatment
45
Cleared hand eczema
46
CHE treatment
Itching reduction
47
Improved AE treatment
48
Eczema treatment
49
Improved IGA
Improved signs
Improved symptoms
50
Emollient creams for eczema
51
Effective treatment
Reduced eczema relapse
52
Reduced corticosteroid consumption
53
Effective for CHE
Well tolerated
54
Improved skin and itch response
Rapid recovery
55
Emollient effectiveness
Shared decision-making
56
Risk Keywords
Worse outcome
3
Frequent doctor visits
Intractable itching
Need for special clothing
Need for topical applications
Skin damage
Sleep loss
Social stigma
Soreness
4
Limited literature
7
Allergic reactions to cow's milk
8
Less effective than corticosteroids
More withdrawals
Skin burning
10
Decreased free thyroxine
Headache
Hyperlipidaemia
Mucocutaneous events
13
Hand eczema
16
Application-site burning
18
Eczema Exacerbations
20
Blood count abnormalities
25
Limited evidence for formulas
No benefit of antistaphylococcal treatment
No benefit of organic food
Poor evidence for bath emollients
Poor evidence for occlusive treatments
Poor evidence for silk clothing
26
Antibiotic use
No evidence for breastfeeding
No evidence for supplements
29
HCP support not strongly valued
Website use not always consistent
30
Unknown mechanisms
32
Erythema
Folliculitis
Pruritus
Smarting
Stinging
36
Topical corticosteroid withdrawal
40
Poor tolerability
41
Disease exacerbation
Eczema herpeticum
Irritation
Phototoxic reaction
Superinfection
UV burn
50
Unclear role in AD development and progression
51
Skin thinning
52
Ethnically diverse backgrounds
Trial and error prescribing
56
Literature analysis of 56 papers
Positive Content
52
Neutral Content
2
Negative Content
2
Article Type
34
10
20
16
56
1.

Fluocinonide compared with betamethasone in the treatment of eczema and psoriasis.

Author: RonnH H

Eczema treatment
Psoriasis treatment

A study found that a single daily application of fluocinonide cream was as effective as twice-daily application of betamethasone valerate cream in treating eczema and psoriasis. Both creams were well-tolerated by patients. Despite positive results, the study acknowledges the difficulty in controlling these conditions and the potential for relapse even with treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Parental education in the treatment of childhood atopic eczema.

Author: BrobergA, KalimoK, LindbladB, SwanbeckG

Eczema treatment

Providing additional information and training about eczema management to parents of 50 children with atopic eczema, in addition to routine medical care, resulted in better therapeutic outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Psychiatric treatment of eczema: a controlled trial.

Author: BrownD G, BettleyF R

Improved eczema outcome
Worse outcome

A study of 72 eczema patients found that brief psychiatric treatment in addition to dermatological care improved outcomes for patients with overt emotional disturbance, new psychological symptoms preceding the rash, and high motivation for treatment. However, it may worsen outcomes in the short term for those without these factors.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Topical tacrolimus (FK506) and mometasone furoate in treatment of dyshidrotic palmar eczema: a randomized, observer-blinded trial.

Author: SchnoppChristina, RemlingRoland, MöhrenschlagerMatthias, WeiglLorenz, RingJohannes, AbeckDietrich

Treats eczema

Tacrolimus 0.1% ointment and mometasone furoate 0.1% ointment both reduced dyshidrotic eczema symptoms in palmar areas after 2 weeks, but tacrolimus was less effective long-term.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Novel treatment of chronic severe hand dermatitis with bexarotene gel.

Author: HanifinJ M, StevensV, ShethP, BrenemanD

Reduced hand dermatitis

Topical corticosteroids are effective for milder forms of hand dermatitis, but their effectiveness often diminishes over time and they can cause skin atrophy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Topical corticosteroids for atopic eczema: clinical and cost effectiveness of once-daily vs. more frequent use.

Author: GreenC, ColquittJ L, KirbyJ, DavidsonP

Least cost
No difference
Limited literature

Once-daily use of topical corticosteroids was not found to be less effective than more frequent application in treating atopic eczema.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Acute allergic reactions in children with AEDS after prolonged cow's milk elimination diets.

Author: FlintermanA E, KnulstA C, MeijerY, Bruijnzeel-KoomenC A F M, PasmansS G M A

Allergic reactions to cow's milk

Children with atopic eczema dermatitis syndrome (AEDS) who were on a cow's milk (CM) elimination diet for a median of 2.3 years were found to have a high chance of developing acute allergic reactions to CM after accidental ingestion during the elimination period. Double-blind placebo-controlled food challenge (DBPCFC) revealed that all 11 children experienced acute allergic reactions to CM, despite having no previous problems with CM intake before the elimination period.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Pimecrolimus cream 1% is effective in asteatotic eczema: results of a randomized, double-blind, vehicle-controlled study in 40 patients.

Author: SchulzP, BunselmeyerB, BräutigamM, LugerT A

Effective for asteatotic eczema

Pimecrolimus cream 1% was effective in treating asteatotic eczema, reducing eczema severity, pruritus, and improving patient self-assessment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Topical pimecrolimus for eczema.

Author: AshcroftD M, ChenL-C, GarsideR, SteinK, WilliamsH C

Effective eczema treatment
Improved quality of life
Less effective than corticosteroids
More withdrawals
Skin burning

This review found that topical pimecrolimus is less effective than moderate and potent corticosteroids and 0.1% tacrolimus in treating eczema (atopic dermatitis).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Pimecrolimus 1% cream in the treatment of facial psoriasis: a 16-week open-label study.

Author: JacobiArnd, BraeutigamMatthias, MahlerVera, SchultzErwin, HertlMichael

Improved psoriasis symptoms

Pimecrolimus 1% cream was effective and well tolerated in the treatment of facial psoriasis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

The efficacy of '0.05% Clobetasol + 2.5% zinc sulphate' cream vs. '0.05% Clobetasol alone' cream in the treatment of the chronic hand eczema: a double-blind study.

Author: FaghihiG, IrajiF, ShahingoharA, SaidatAh

Improved hand eczema

The combination of 0.05% Clobetasol and 2.5% zinc sulphate cream was more effective than 0.05% Clobetasol alone cream in treating chronic hand eczema. It also showed a significantly lower recurrence rate.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial.

Author: RuzickaT, LyndeC W, JemecG B E, DiepgenT, Berth-JonesJ, CoenraadsP J, KaszubaA, BissonnetteR, VarjonenE, HollóP, CambazardF, LahfaM, ElsnerP, NybergF, SvenssonA, BrownT C, HarschM, MaaresJ

Improved CHE
Decreased free thyroxine
Headache
Hyperlipidaemia
Mucocutaneous events

Oral alitretinoin was effective in inducing clearing of CHE in a substantial proportion of patients with severe disease refractory to standard therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

The effect of ceramide-containing skin care products on eczema resolution duration.

Author: DraelosZoe Diana

Eczema treatment

Incorporating ceramides into a liquid cleanser and moisturizing cream enhanced the treatment outcome of mild to moderate eczema compared with using a bar cleanser.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Treatment following an evidence-based algorithm versus individualised symptom-oriented treatment for atopic eczema. A randomised controlled trial.

Author: SchmittJochen, MeurerMichael, SchwanebeckUta, GrahlertXina, SchakelKnut

Atopic eczema treatment

Treatment following an evidence-based algorithm is an effective and applicable concept for the management of atopic eczema.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

[Ultraviolet therapy in patients with chronic hand eczema].

Author: StegeH

Improved hand eczema treatment
Hand eczema

Hand eczema is commonly treated with topical steroid creams. When topical treatments fail, ultraviolet (UV) therapy alone or in combination with other treatments is the preferred second-line approach. UVB and PUVA (psoralen plus UVA) therapy are effective and have minimal side effects. Applying PUVA directly to the skin is better than using it systemically due to the localized nature of the condition. A new retinoid called alitretinoin has also shown promise, but no treatment guarantees a cure for all patients. UV therapy combined with other treatments is recommended when oral retinoids are ineffective.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

17.

Evaluation of topical vitamin B(12) for the treatment of childhood eczema.

Author: JanuchowskiRonald

Atopic dermatitis treatment

This study aimed to investigate the effectiveness of topical vitamin B(12) as an alternative treatment for eczema in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Superiority of tacrolimus 0.1% ointment compared with fluticasone 0.005% in adults with moderate to severe atopic dermatitis of the face: results from a randomized, double-blind trial.

Author: DossN, ReitamoS, DubertretL, FeketeG L, KamounM-R, LahfaM, OrtonneJ-P

Atopic dermatitis treatment
Effective second-line treatment
Safe and effective
Application-site burning

Tacrolimus 0.1% ointment was more effective than fluticasone 0.005% ointment for twice-daily treatment of moderate to severe facial atopic dermatitis. Tacrolimus 0.1% ointment is a safe and effective second-line treatment for facial atopic dermatitis.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Treatment with a barrier-strengthening moisturizing cream delays relapse of atopic dermatitis: a prospective and randomized controlled clinical trial.

Author: WirénK, NohlgårdC, NybergF, HolmL, SvenssonM, JohannessonA, WallbergP, BerneB, EdlundF, LodénM

Skin barrier repair

The current approach to managing atopic dermatitis (eczema) involves using topical medications like steroids or calcineurin inhibitors to treat flares and moisturizers to address dry skin. This study highlights the importance of improving skin barrier function, which is disrupted in eczema, to potentially prevent or reduce flare-ups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Prednisolone vs. ciclosporin for severe adult eczema. An investigator-initiated double-blind placebo-controlled multicentre trial.

Author: SchmittJ, SchäkelK, Fölster-HolstR, BauerA, OertelR, AugustinM, AbererW, LugerT, MeurerM

Improved Eczema Symptoms
Eczema Exacerbations

Ciclosporin was significantly more effective than prednisolone for severe adult eczema.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

What's new in atopic eczema? An analysis of systematic reviews published in 2007 and 2008. Part 2. Disease prevention and treatment.

Author: WilliamsH C, GrindlayD J C

Eczema treatment

This review examined recent research on preventing and treating eczema. Two reviews found evidence that probiotics taken by mothers during pregnancy may reduce the risk of eczema in their children. One large review of breastfeeding found some evidence of protection against eczema, but more research is needed. No clear evidence supports the use of prebiotics for eczema prevention, and exposure to cats or dogs at birth did not increase eczema risk. In terms of treatment, two reviews confirmed the effectiveness of topical tacrolimus ointment, and another review supported the effectiveness of topical pimecrolimus, although many studies used a placebo that was not a true comparison. A review of desensitization therapy (introducing the allergen gradually) found some evidence of benefit, needing further investigation. Despite its popularity, a review found no clear benefit of treating eczema with anti-staphylococcal therapies, and another review found little evidence to support dietary changes for eczema, except for avoiding eggs in babies with suspected egg allergy. Finally, a review of probiotics for treating eczema found no convincing evidence for their effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

What's new in atopic eczema? An analysis of systematic reviews published in 2008 and 2009.

Author: BatchelorJ M, GrindlayD J C, WilliamsH C

Treatment for AE

This review summarizes clinically important findings from nine systematic reviews of the causes, treatment, and prevention of atopic eczema (AE).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Efficacy and tolerability of proactive treatment with topical corticosteroids and calcineurin inhibitors for atopic eczema: systematic review and meta-analysis of randomized controlled trials.

Author: SchmittJ, von KobyletzkiL, SvenssonA, ApfelbacherC

Reduced flares

Topical tacrolimus, fluticasone propionate, and methylprednisolone aceponate were effective in preventing atopic eczema flares. Fluticasone propionate was more effective than tacrolimus in preventing flares.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Treatment with a barrier-strengthening moisturizer prevents relapse of hand-eczema. An open, randomized, prospective, parallel group study.

Author: LodénMarie, WirénKarin, SmerudKnut, MelandNils, HønnåsHelge, MørkGro, Lützow-HolmClaus, FunkJörgen, MedingBirgitta

Improved quality of life
Prolonged disease-free interval

This study compared the time to relapse of eczema during treatment with a barrier-strengthening moisturizer to no treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

A randomized trial of methotrexate versus azathioprine for severe atopic eczema.

Author: SchramMandy Elvira, RoekevischEvelien, LeeflangMariska Maria Geertruida, BosJan Dositheus, SchmittJochen, SpulsPhyllis Ira

Eczema improvement
Safe treatment
Blood count abnormalities

Both methotrexate and azathioprine achieved clinically relevant improvement and were safe in the short term. Methotrexate and azathioprine are appropriate options for the treatment of severe atopic eczema. At week 12, patients in the methotrexate group had a mean relative reduction in the severity scoring of atopic dermatitis index of 42% (SD, 18%) compared with 39% (SD, 25%) in the azathioprine group (P = .52).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

Dietary supplements for established atopic eczema.

Author: Bath-HextallFiona J, JenkinsonClaire, HumphreysRosemary, WilliamsHywel C

Treatment of atopic eczema

Many people with atopic eczema are hesitant to use common treatments due to concerns about long-term effects. As a result, many turn to dietary supplements, often believing that their diet lacks something essential. While various supplements are suggested, their effectiveness for eczema is unclear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Oral evening primrose oil and borage oil for eczema.

Author: BamfordJoel T M, RaySujoy, MusekiwaAlfred, van GoolChristel, HumphreysRosemary, ErnstEdzard

Eczema treatment

Eczema is a chronic skin condition that is often treated with conventional medical products. This review will examine the use of evening primrose oil (EPO) and borage oil (BO) as complementary alternative treatments for eczema.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

What's new in atopic eczema? An analysis of systematic reviews published in 2010-11.

Author: TorleyD, FutamuraM, WilliamsH C, ThomasK S

Dog exposure
Early daycare
Endotoxin exposure
Topical anti-inflammatories
Unpasteurized milk
Antibiotic use
No evidence for breastfeeding
No evidence for supplements

This review summarizes key findings from 24 systematic reviews on atopic eczema (AE). Early daycare, endotoxin exposure, unpasteurized milk consumption, and early dog exposure may be protective, while early antibiotic use may increase AE risk. There is no strong evidence for the benefits of exclusive breastfeeding, hydrolysed protein formulas, soy formulas, maternal antigen avoidance, omega-3 or omega-6 fatty-acid supplementation, or prebiotics or probiotics for AE prevention. Proactive treatment with topical anti-inflammatory agents is effective in preventing AE flares. Tacrolimus 0.1% is superior to pimecrolimus for treating AE, and tacrolimus is similar in efficacy to mild/moderate topical corticosteroids. Evidence for the role of education in managing AE is inconclusive. There is no clear evidence for the efficacy of homeopathy, botanical extracts, or Chinese herbal medicine in treating AE.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

Supporting self-care for families of children with eczema with a Web-based intervention plus health care professional support: pilot randomized controlled trial.

Author: SanterMiriam, MullerIngrid, YardleyLucy, BurgessHana, SelingerHannah, StuartBeth L, LittlePaul

Eczema improvement
Web-based intervention
HCP support not strongly valued
Website use not always consistent

A pilot trial of a web-based intervention to support families of children with eczema found that the intervention group had a decrease of ≥2 in follow-up compared with baseline POEM score in 55% of participants. The trial found that HCP support was not strongly valued by participants and did not lead to better outcomes or website use than use of the web-based intervention alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

What's new in atopic eczema? An analysis of systematic reviews published in 2012 and 2013. Part 2. Treatment and prevention.

Author: MadhokV, FutamuraM, ThomasK S, BarbarotS

Prevent atopic eczema
Treat atopic eczema

This review summarizes key findings from systematic reviews on atopic eczema (AE), focusing on prevention and treatment. The review discusses the effectiveness of probiotics, exposure to pets, and other interventions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

Serum Vitamin D levels and Vitamin D supplementation do not correlate with the severity of chronic eczema in children.

Author: GalliE, RocchiL, CarelloR, GiampietroP G, PaneiP, MeglioP

Eczema treatment
Unknown mechanisms

Eczema is a common skin condition affecting many children. While the exact causes are not fully understood, recent research suggests Vitamin D may play a crucial role in its development. Treatment options for moderate-to-severe eczema are often challenging.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

Topical treatment with fresh human milk versus emollient on atopic eczema spots in young children: a small, randomized, split body, controlled, blinded pilot study.

Author: BerentsTeresa Løvold, RønnevigJørgen, SøylandElisabeth, GaustadPeter, NylanderGro, LølandBeate Fossum

AE treatment

Fresh human milk has been used as a treatment for conjunctivitis, rhinitis, and atopic eczema (AE). This pilot study examines the potential benefits and risks of applying fresh human milk topically to eczema spots in children with AE.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

34.

Choice of Moisturiser for Eczema Treatment (COMET): study protocol for a randomized controlled trial.

Author: RiddMatthew J, RedmondNiamh M, HollinghurstSandra, BallNicola, ShawLindsay, GuyRichard, WilsonVictoria, MetcalfeChris, PurdySarah

Emollients for eczema

Eczema is common in children, and most cases are treated in primary care. Regular use of moisturizers is crucial to manage eczema, improving comfort and potentially reducing the need for other treatments. While there are many moisturizers available, there is limited research to guide the best choice. Conducting studies is challenging because it is difficult to get parents to participate in long-term trials where they are randomly assigned different moisturizers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

35.

Efficacy of proactive long-term maintenance therapy of canine atopic dermatitis with 0.0584% hydrocortisone aceponate spray: a double-blind placebo controlled pilot study.

Author: LourençoAna M, SchmidtVanessa, São BrazBerta, NóbregaDiana, NunesTelmo, Duarte-CorreiaJosé H, MatiasDaniela, MaruhashiEmi, RèmeChristophe A, NuttallTim

Flare prevention

Long-term remission of canine atopic dermatitis (CAD) is challenging to achieve. This study examines the potential benefits of proactive therapy for CAD flare prevention.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

36.

Emollients and moisturisers for eczema.

Author: van ZuurenEsther J, FedorowiczZbys, ChristensenRobin, LavrijsenAdriana, ArentsBernd WM

Eczema reduction
Flare prevention
Itch reduction
Quality of life improvement
Erythema
Folliculitis
Pruritus
Smarting
Stinging

This systematic review assessed the effects of moisturisers for eczema. The review found that most moisturisers showed some beneficial effects, producing better results when used with active treatment, prolonging time to flare, and reducing the number of flares and amount of topical corticosteroids needed to achieve similar reductions in eczema severity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Atopic Dermatitis Anti-IgE Paediatric Trial (ADAPT): the role of anti-IgE in severe paediatric eczema: study protocol for a randomised controlled trial.

Author: ChanSusan, CorneliusVictoria, ChenTao, RadulovicSuzana, WanMandy, JahanRahi, LackGideon

Childhood eczema treatment

This study aimed to assess whether anti-IgE treatment (omalizumab) improves eczema compared to placebo in children with severe childhood eczema.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

38.

Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children (The BEEP trial): protocol for a randomised controlled trial.

Author: ChalmersJoanne R, HainesRachel H, MitchellEleanor J, ThomasKim S, BrownSara J, RiddMatthew, LawtonSandra, SimpsonEric L, CorkMichael J, SachTracey H, BradshawLucy E, MontgomeryAlan A, BoyleRobert J, WilliamsHywel C

AE prevention

This trial aims to investigate whether daily application of emollients in the first year of life can prevent the development of atopic eczema (AE) in high-risk infants. The abstract highlights the significant impact of AE on quality of life and the associated risk of developing other atopic diseases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

39.

The views of children and young people on the use of silk garments for the treatment of eczema: a nested qualitative study within the CLOTHing for the relief of Eczema Symptoms (CLOTHES) randomized controlled trial.

Author: WakeE V, BatchelorJ, LawtonS, ThomasK S, HarrisonE F, CowdellF C,

Atopic eczema management

This study explores the experiences of children and young people with atopic eczema (AE), specifically focusing on the role of specialist clothing in managing the condition. The abstract highlights the need for more research in dermatology to include the perspectives of children and young people.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

40.

What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 2: prevention and treatment.

Author: Lloyd-LaveryA, RogersN K, DaviesE, GrindlayD J C, ThomasK S

Improved AE control
Reduced AE severity
Topical corticosteroid withdrawal

A review of the evidence base for atopic eczema (AE) found that topical corticosteroid withdrawal syndrome, 'steroid addiction', has been evaluated in a high-quality systematic review, and a Cochrane Review has not demonstrated any association between topical corticosteroid use in pregnancy and adverse outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

Leukotriene receptor antagonists for eczema.

Author: FergusonLeila, FutamuraMasaki, VakirlisEfstratios, KojimaReiji, SasakiHatoko, RobertsAmanda, MoriRintaro

Eczema treatment
LTRAs
Poor tolerability

Eczema is a common and chronic skin condition often associated with allergies, including asthma. While medications that block leukotrienes (LTRAs) are used to reduce the need for steroids in asthma, their role in eczema is still unclear. Current treatments for eczema often cause side effects, and stronger medications have limitations. This highlights the need for new treatments for eczema.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT.

Author: SanterMiriam, RumsbyKate, RiddMatthew J, FrancisNick A, StuartBeth, ChorozoglouMaria, RobertsAmanda, LiddiardLyn, NollettClaire, HooperJulie, PrudeMartina, WoodWendy, Thomas-JonesEmma, BecqueTaeko, ThomasKim S, WilliamsHywel C, LittlePaul

A randomized controlled trial of 482 children with childhood eczema found no evidence that emollient bath additives provide clinical benefit when added to standard eczema management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

43.

Probiotics for treating eczema.

Author: MakrgeorgouAreti, Leonardi-BeeJo, Bath-HextallFiona J, MurrellDedee F, TangMimi Lk, RobertsAmanda, BoyleRobert J

Probiotics are increasingly used to treat eczema, but their effectiveness is debated. This updated review examines the evidence for probiotic use in eczema treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Oral H1 antihistamines as 'add-on' therapy to topical treatment for eczema.

Author: MatterneUwe, BöhmerMerle Margarete, WeisshaarElke, JupiterAldrin, CarterBen, ApfelbacherChristian J

Eczema treatment
H1 AH

This study investigates the potential benefits of using oral H1 antihistamines (H1 AH) alongside topical treatments for eczema. While topical treatments are standard, the idea is that combining them with H1 AH, which block histamine receptors in the skin and reduce itching, could improve treatment effectiveness. However, comparing H1 AH alone to no treatment would be unethical as topical treatment is considered standard care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 1: treatment and prevention.

Author: SolmanL, Lloyd-LaveryA, GrindlayD J C, RogersN K, ThomasK S, HarmanK E

Improved AE treatment

Topical corticosteroids and calcineurin inhibitors show similar effectiveness in treating atopic eczema (AE), with topical corticosteroids being the standard of care due to lower cost and fewer adverse reactions. There is limited evidence supporting the use of other treatments, including omalizumab, specific allergen immunotherapy, vitamin D supplementation, synbiotics, wet wraps, and complementary/alternative medicine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

Efficacy and safety of topical delgocitinib in patients with chronic hand eczema: data from a randomized, double-blind, vehicle-controlled phase IIa study.

Author: WormM, BauerA, ElsnerP, MahlerV, MolinS, NielsenT S S

Cleared hand eczema

Topical delgocitinib ointment was effective and well tolerated in a randomized, double-blind, phase IIa study of 91 patients with chronic hand eczema. Treatment success was achieved in 46% of patients receiving delgocitinib versus 15% of patients receiving vehicle (odds ratio 4.89). Further clinical studies are warranted to confirm these findings.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

47.

Synergistic Effects of the 308-nm Excimer Light and Topical Calcipotriol for the Treatment of Chronic Hand Eczema: A Randomized Controlled Study.

Author: JuntongjinPremjit, ChunhakhamPradtana

CHE treatment
Itching reduction

Combined monochromatic 308-nm excimer light (MEL) and topical calcipotriol therapy showed greater efficacy in treating chronic hand eczema (CHE) compared to topical calcipotriol alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

48.

What's new in atopic eczema? An analysis of systematic reviews published in 2018. Part 1: prevention and topical therapies.

Author: TaskerF, BrownA, GrindlayD J C, RogersN K, HarmanK E

Improved AE treatment

This review summarizes key findings from 14 systematic reviews on the prevention and topical treatment of atopic eczema (AE) published in 2018.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

Systemic treatments for eczema: a network meta-analysis.

Author: SawangjitRatree, DilokthornsakulPiyameth, Lloyd-LaveryAntonia, LaiNai Ming, DellavalleRobert, ChaiyakunaprukNathorn

Eczema treatment

Eczema is a common skin condition that can cause significant discomfort and affect quality of life. While treatments exist to manage eczema, particularly for those with severe cases, there aren't many studies comparing different treatments directly to determine which works best.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

Phototherapy for atopic eczema.

Author: MustersAnnelie H, MashayekhiSoudeh, HarveyJane, AxonEmma, LaxStephanie J, FlohrCarsten, DruckerAaron M, GerbensLouise, FergusonJohn, IbbotsonSally, DaweRobert S, GarritsenFloor, BrouwerMarijke, LimpensJacqueline, PrescottLaura E, BoyleRobert J, SpulsPhyllis I

Improved IGA
Improved signs
Improved symptoms
Disease exacerbation
Eczema herpeticum
Irritation
Phototoxic reaction
Superinfection
UV burn

Narrowband ultraviolet B (NB-UVB) phototherapy may improve physician-rated signs, patient-reported symptoms, and Investigator Global Assessment (IGA) of atopic eczema (AE) after 12 weeks of treatment, without a difference in withdrawal due to adverse events compared to placebo or no treatment. Evidence for ultraviolet A1 (UVA1) compared to NB-UVB or psoralen plus ultraviolet A (PUVA), and NB-UVB compared to PUVA was very low certainty. More information is needed on the safety and effectiveness of all aspects of phototherapy for treating AE.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

51.

Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis.

Author: DanbySimon G, AndrewPaul V, TaylorRosie N, KayLinda J, ChittockJohn, PinnockAbigail, UlhaqIntisar, FasthAnna, CarlanderKarin, HolmTina, CorkMichael J

Emollient creams for eczema
Unclear role in AD development and progression

This study investigates the effects of different types of emollient creams on skin barrier function in individuals with eczema (atopic dermatitis; AD). Emollients are widely used to manage eczema, but their impact on skin barrier function remains unclear.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

52.

Strategies for using topical corticosteroids in children and adults with eczema.

Author: LaxStephanie J, HarveyJane, AxonEmma, HowellsLaura, SanterMiriam, RiddMatthew J, LawtonSandra, LanganSinéad, RobertsAmanda, AhmedAmina, MullerIngrid, MingLong Chiau, PandaSaumya, ChernyshovPavel, CarterBen, WilliamsHywel C, ThomasKim S, ChalmersJoanne R

Effective treatment
Reduced eczema relapse
Skin thinning

This systematic review evaluated the effectiveness and safety of different ways of using topical corticosteroids for treating eczema. Potent and moderate topical corticosteroids are probably more effective than mild topical corticosteroids in moderate or severe eczema, but there is uncertain evidence to support any advantage of very potent over potent topical corticosteroids. Topical corticosteroids weekend (proactive) therapy is probably better than no topical corticosteroids/reactive use to prevent eczema relapse. Further research is needed on the optimal duration of treatment and the time to leave between application of topical corticosteroids and emollient.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

55.

Upadacitinib treatment withdrawal and retreatment in patients with moderate-to-severe atopic dermatitis: Results from a phase 2b, randomized, controlled trial.

Author: Guttman-YasskyEmma, SilverbergJonathan I, ThaçiDiamant, PappKim A, StänderSonja, BeckLisa A, KimBrian S, HuXiaofei, LiuJianzhong, CalimlimBrian M, VignaNamita, CrowleyJameson T, TeixeiraHenrique D, ThyssenJacob P

Improved skin and itch response
Rapid recovery

This study evaluated the effect of upadacitinib withdrawal on skin clearance and itch improvement in adult patients with moderate-to-severe atopic dermatitis (AD). The results show that withdrawing upadacitinib leads to a rapid loss of skin clearance and itch improvement within 4 weeks and 5 days, respectively. Rescue treatment with upadacitinib 30 mg resulted in rapid recovery or improvement of both skin and itch responses. The study concludes that continuous treatment with upadacitinib is suggested to maintain skin clearance and antipruritic effects.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

56.

Comparison of lotions, creams, gels and ointments for the treatment of childhood eczema: the BEE RCT.

Author: RiddMatthew J, WellsSian, MacNeillStephanie J, SandersonEmily, WebbDouglas, BanksJonathan, SuttonEileen, ShawAlison Rg, WilkinsZoe, ClaytonJulie, RobertsAmanda, GarfieldKirsty, LiddiardLyn, BarrettTiffany J, LaneJ Athene, BaxterHelen, HowellsLaura, TaylorJodi, HayAlastair D, WilliamsHywel C, ThomasKim S, SanterMiriam

Emollient effectiveness
Shared decision-making
Ethnically diverse backgrounds
Trial and error prescribing

Four types of emollients (lotion, cream, gel, and ointment) were equally effective in treating childhood eczema. However, satisfaction with the different types varied, with different parents/children preferring different ones. This suggests that users need to have a range of options to find an emollient that suits them.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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