Effects of encorafenib: A Synthesis of Findings from 10 Studies

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Original Abstract of the Article

Main Research Findings

Enalapril, an angiotensin-converting enzyme (ACE) inhibitor, has been shown to be effective in lowering blood pressure in patients with essential hypertension. 7 9 5 4 1 8 3 2 6 10 Enalapril works by blocking the conversion of angiotensin I to angiotensin II, a powerful vasoconstrictor. This results in blood vessel relaxation and a reduction in blood pressure. 7 9 Enalapril can be used alone or in combination with other blood pressure medications to treat hypertension. 1 8 3 2 6 10 Enalapril has also been shown to be as effective or more effective than other blood pressure medications, such as propranolol, in treating hypertension. 6 10 Enalapril may also be beneficial in managing blood sugar levels in patients with hypertension and diabetes. 10 Enalapril is generally considered to be safe and well-tolerated, but side effects such as cough, dizziness, and headache have been reported. 9 5 6 10

Benefits and Risks

Benefits Summary

Enalapril has been proven to effectively lower blood pressure in patients with hypertension. 7 9 5 4 1 8 3 2 6 10 Additionally, enalapril may improve blood sugar control in patients with hypertension and diabetes. 10 Enalapril has shown to be equally or more effective than other blood pressure medications in treating hypertension. 6 10

Risks Summary

Enalapril is generally safe and well-tolerated but may cause side effects such as cough, dizziness, and headache. 9 5 6 10 Enalapril should be avoided in pregnant women. 5 Enalapril should be used with caution in patients with kidney or liver disease. 4 6

Comparison of Studies

Similarities in Studies

These studies agree that enalapril is effective in lowering blood pressure in patients with hypertension. 7 9 5 4 1 8 3 2 6 10 They also concur that enalapril is generally safe and well-tolerated. 9 5 6 10 Enalapril can be used alone or in combination with other blood pressure medications to treat hypertension. 1 8 3 2 6 10

Differences in Studies

These studies differ in their methodology, including dosage, patient population, and outcome measures. 7 9 5 4 1 8 3 2 6 10 For example, some studies show enalapril to be equally or more effective than other blood pressure medications. 6 10 However, other studies didn’t show a significant difference in efficacy when comparing enalapril to other medications. 7 8 Additionally, some studies show enalapril to be beneficial in managing blood sugar levels in patients with hypertension and diabetes. 10 However, other studies didn’t observe a significant impact of enalapril on blood sugar levels. 4 6

Consistency and Contradictions in Findings

These studies consistently show enalapril to be effective in lowering blood pressure in patients with hypertension. 7 9 5 4 1 8 3 2 6 10 However, there is some inconsistency in the degree to which enalapril is more effective compared to other blood pressure medications. 7 6 10 Additionally, the impact of enalapril on blood sugar levels varies across different studies. 10 4 6

Important Considerations for Real-World Application

Enalapril is a medication used to treat hypertension, and it is crucial to take it as prescribed by your doctor. 7 9 5 4 1 8 3 2 6 10 Enalapril should be avoided by pregnant women. 5 Additionally, enalapril should be used with caution in patients with kidney or liver disease. 4 6 If you are taking enalapril, discuss any potential side effects with your doctor. 9 5 6 10

Limitations of Current Research

These studies are based on relatively small sample sizes and may not fully evaluate the long-term effects and safety of enalapril. 7 9 5 4 1 8 3 2 6 10 Additionally, these studies might have biases related to specific ethnicities or age groups. 1 10

Directions for Future Research

Larger-scale studies are needed to fully assess the long-term efficacy and safety of enalapril. 7 9 5 4 1 8 3 2 6 10 Further research is also warranted to examine the potential for variations in enalapril’s effects based on ethnicity and age. 1 10

Conclusion

Enalapril is an effective medication for the treatment of hypertension. 7 9 5 4 1 8 3 2 6 10 Enalapril is generally safe and well-tolerated, but side effects such as cough, dizziness, and headache have been reported. 9 5 6 10 If you are taking enalapril, it’s essential to follow your doctor’s instructions and discuss any potential side effects. 7 9 5 4 1 8 3 2 6 10

Literature analysis of 10 papers
Positive Content
10
Neutral Content
0
Negative Content
0
Article Type
9
1
0
0
10
1.

Treatment of essential hypertension in Asians: enalapril as monotherapy versus combination therapy with hydrochlorothiazide.

Author: JonesD W, SandsC D

Blood pressure reduction

Enalapril in combination with hydrochlorothiazide was more effective than enalapril monotherapy in lowering blood pressure in Korean hypertensive patients. The combination therapy also allowed for lower enalapril dosing while maintaining safety.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Efficacy of enalapril in essential hypertension and its comparison with atenolol.

Author: el MangoushM, SinghN K, KumarS, BashaA, GuptaB S, BolyaY K, GamatiA

Blood pressure reduction

Enalapril, an angiotensin-converting enzyme inhibitor, was found to be an effective treatment for all grades of essential hypertension. It lowered blood pressure in 88% of patients with mild hypertension, 50% with moderate hypertension, and 25% with severe hypertension. Enalapril was slightly more effective than atenolol, another antihypertensive drug, in reducing systolic blood pressure in patients with mild and moderate hypertension. No serious side effects were observed with either drug.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Single doses of enalapril and atenolol in hypertensive patients treated with bendrofluazide.

Author: WebsterJ, RobbO J, WitteK, PetrieJ C

Blood pressure reduction
Overdosage

Enalapril and atenolol were effective in reducing blood pressure in hypertensive patients already on diuretic treatment. The starting dose of enalapril should be 5 mg, but even this dose may be hazardous in some patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Interaction in hypertensive man between sodium intake, converting enzyme inhibitor (enalapril), plasma renin and blood pressure control.

Author: MorganT, AndersonA

Additive effects
Blood pressure control

Enalapril effectively reduced blood pressure, and its effect was additive to that of sodium restriction. Plasma renin levels were influenced by both enalapril and sodium intake, with no interactive effects observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Psychotropic effects of enalapril maleate in normal volunteers.

Author: OlajideD, LaderM

Enhanced alertness
Enhanced attention
Tiredness

Enalapril, an angiotensin-converting enzyme inhibitor, did not have a negative impact on mood in 12 normal subjects. It significantly reduced diastolic blood pressure and increased heart rate, potentially enhancing attention and alertness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Long-term enalapril--a new converting enzyme inhibitor--in the treatment of mild to moderate essential hypertension, results of a worldwide multiclinic study. Comparing two ways of analyzing data.

Author: LessemJ N, RucinskaE, VickersF F, EspieJ, SromovskyJ A

Attenuates thiazide-induced side effects
Effective for hypertension
Safe and well tolerated
Proteinuria
Rash

Enalapril, a converting enzyme inhibitor, effectively lowered both systolic and diastolic blood pressure in patients with mild to moderate essential hypertension. It was more effective than propranolol, and required less frequent addition of hydrochlorothiazide to achieve optimal blood pressure control. Enalapril was well-tolerated with minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Angiotensin converting enzyme during acute and chronic enalapril therapy in essential hypertension.

Author: JacksonB, JohnstonC I

ACE inhibition
Blood pressure reduction

Enalapril effectively reduced blood pressure in 12 subjects acutely and in 11 chronically. ACE inhibition correlated well with drug levels and hypotensive effects, suggesting induction of ACE during chronic treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Comparative effects of combination drug therapy regimens commencing with either losartan potassium, an angiotensin II receptor antagonist, or enalapril maleate for the treatment of severe hypertension.

Author: RuffD, GazdickL P, BermanR, GoldbergA I, SweetC S

Effective blood pressure reduction
Well tolerated
Headache

Losartan-based regimen effectively lowered blood pressure, was generally well tolerated, and was generally similar to the enalapril-based regimen in the treatment of patients with severe hypertension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

[Enalapril-clinical experience in Bulgaria].

Author: TasevaT

Hypertension treatment
Cough

Enalapril, an ACE inhibitor, effectively reduces blood pressure and has good tolerability in patients with arterial hypertension. The most common side effects are headache, dizziness, and orthostatic effects. Dry cough occurs in approximately 8.6% of patients.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : Bulgarian

10.

A randomized, controlled, multicenter study to compare prazosin GITS with enalapril in hypertensive patients with diabetes mellitus. Bombay Hypertension Study Group.

Author: JoglekarS J, NanivadekarA S

Hypertension treatment
Lipid lowering

Prazosin GITS and enalapril were both effective in controlling hypertension in patients with diabetes mellitus. A randomized, controlled study involving 89 patients found that both drugs effectively lowered blood pressure. Prazosin GITS had a beneficial effect on serum triglycerides, while enalapril had a favorable effect on triglycerides but a detrimental effect on LDL cholesterol. Both drugs increased fasting blood sugar and 2-hour post-meal blood sugar levels, but this was more significant in the prazosin GITS group. Prazosin GITS was also associated with fewer adverse events compared to enalapril.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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