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Long-term enalapril--a new converting enzyme inhibitor--in the treatment of mild to moderate essential hypertension, results of a worldwide multiclinic study. Comparing two ways of analyzing data.

Author: EspieJ, LessemJ N, RucinskaE, SromovskyJ A, VickersF F

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Enalapril, a converting enzyme inhibitor, effectively lowered both systolic and diastolic blood pressure in patients with mild to moderate essential hypertension. It was more effective than propranolol, and required less frequent addition of hydrochlorothiazide to achieve optimal blood pressure control. Enalapril was well-tolerated with minimal side effects.
Paper Details　
Original Abstract of the Article :
The antihypertensive effect of enalapril maleate, a new converting enzyme inhibitor, was evaluated in a multiclinic, double-blind, randomized study in patients with mild to moderate essential hypertension. The analyses were done in two ways, with patients who violated the entry criteria of the proto...See full text at original site
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引用元：
https://doi.org/10.3109/10641968509073607

データ提供：米国国立医学図書館（NLM）

Long-Term Enalapril in the Treatment of Mild to Moderate Essential Hypertension

This multiclinic, double-blind, randomized study investigates the long-term efficacy and safety of enalapril maleate, a new converting enzyme inhibitor, in treating mild to moderate essential hypertension. The study compared enalapril to propranolol in patients receiving either medication alone or in combination with hydrochlorothiazide. The results demonstrate that enalapril effectively lowers blood pressure and is well-tolerated over an extended period. The study also suggests that enalapril may attenuate some of the side effects associated with thiazide diuretics.

Enalapril: A Promising Antihypertensive Treatment

The study's findings provide strong evidence that enalapril is an effective and well-tolerated treatment option for mild to moderate essential hypertension. The results demonstrate the drug's efficacy in lowering blood pressure, while also suggesting potential benefits in terms of minimizing side effects. This research is like a cool spring in the desert of hypertension research, offering a refreshing and effective treatment option.

Navigating the Desert of Hypertension

The study's findings offer valuable information for individuals managing hypertension. The research suggests that enalapril can be a safe and effective treatment option, potentially reducing the need for additional medications and mitigating some of the common side effects associated with other antihypertensive drugs. This is like finding a reliable guide through the often-challenging landscape of hypertension management.

Dr.Camel's Conclusion

The study's findings indicate that enalapril is an effective and well-tolerated treatment option for hypertension. The research highlights the drug's efficacy in lowering blood pressure and its potential to mitigate some of the side effects associated with other antihypertensive medications.

Date :
  1. Date Completed 1986-03-14
  2. Date Revised 2019-09-19
Further Info :

Pubmed ID

3002672

DOI: Digital Object Identifier

10.3109/10641968509073607

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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