Effects of epinastine ophthalmic: A Synthesis of Findings from 10 Studies

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Original Abstract of the Article

Major Research Findings

Enalapril is an angiotensin-converting enzyme inhibitor used to treat high blood pressure. Multiple studies have shown that enalapril lowers blood pressure and reduces the strain on the heart. 5 , 7 , 3 , 1 , 6 , 4 , 9 , 2 , 8 , 10 Research suggests that enalapril is an effective drug for treating high blood pressure, used as monotherapy or in combination with other drugs. In addition, enalapril may reduce the risk of heart failure, kidney disease, and stroke.

Benefits and Risks

Benefits Summary

Enalapril is effective in treating high blood pressure and may reduce the strain on the heart. It may also reduce the risk of heart failure, kidney disease, and stroke.

Risks Summary

Side effects of enalapril include cough, dizziness, headache, and low blood pressure. In rare cases, serious side effects may occur. When taking enalapril, follow your doctor's instructions and take it carefully.

Comparison Between Studies

Commonalities of the Studies

Multiple studies have shown that enalapril lowers blood pressure. In addition, enalapril may reduce the risk of heart failure, kidney disease, and stroke.

Differences of the Studies

The frequency and severity of side effects of enalapril may vary depending on the study. The effectiveness of enalapril may vary depending on the patient's age and health condition.

Consistency and Inconsistencies in Results

The effectiveness of enalapril is consistently demonstrated across multiple studies. However, differences exist regarding the frequency and severity of side effects. The effectiveness of enalapril may vary depending on the patient's age and health condition.

Cautions for Real-World Application

Enalapril is an effective drug for treating high blood pressure, but there is a possibility of side effects. When taking enalapril, follow your doctor's instructions and take it carefully.

Limitations of Current Research

Further research is needed on the long-term effects and safety of enalapril. The effectiveness of enalapril may vary depending on the patient's age and health condition.

Future Research Directions

Research is needed to evaluate the long-term effects and safety of enalapril. Research is also needed to clarify how the effectiveness of enalapril differs depending on the patient's age and health condition.

Conclusion

Enalapril is an effective drug for treating high blood pressure. However, there is a possibility of side effects. When taking enalapril, follow your doctor's instructions and take it carefully. Further research is needed on the long-term effects and safety of enalapril.

Literature analysis of 10 papers
Positive Content
10
Neutral Content
0
Negative Content
0
Article Type
9
1
0
0
10
1.

Treatment of essential hypertension in Asians: enalapril as monotherapy versus combination therapy with hydrochlorothiazide.

Author: JonesD W, SandsC D

Blood pressure reduction

Enalapril in combination with hydrochlorothiazide was more effective than enalapril monotherapy in lowering blood pressure in Korean hypertensive patients. The combination therapy also allowed for lower enalapril dosing while maintaining safety.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Efficacy of enalapril in essential hypertension and its comparison with atenolol.

Author: el MangoushM, SinghN K, KumarS, BashaA, GuptaB S, BolyaY K, GamatiA

Blood pressure reduction

Enalapril, an angiotensin-converting enzyme inhibitor, was found to be an effective treatment for all grades of essential hypertension. It lowered blood pressure in 88% of patients with mild hypertension, 50% with moderate hypertension, and 25% with severe hypertension. Enalapril was slightly more effective than atenolol, another antihypertensive drug, in reducing systolic blood pressure in patients with mild and moderate hypertension. No serious side effects were observed with either drug.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Single doses of enalapril and atenolol in hypertensive patients treated with bendrofluazide.

Author: WebsterJ, RobbO J, WitteK, PetrieJ C

Blood pressure reduction
Overdosage

Enalapril and atenolol were effective in reducing blood pressure in hypertensive patients already on diuretic treatment. The starting dose of enalapril should be 5 mg, but even this dose may be hazardous in some patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Interaction in hypertensive man between sodium intake, converting enzyme inhibitor (enalapril), plasma renin and blood pressure control.

Author: MorganT, AndersonA

Additive effects
Blood pressure control

Enalapril effectively reduced blood pressure, and its effect was additive to that of sodium restriction. Plasma renin levels were influenced by both enalapril and sodium intake, with no interactive effects observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Psychotropic effects of enalapril maleate in normal volunteers.

Author: OlajideD, LaderM

Enhanced alertness
Enhanced attention
Tiredness

Enalapril, an angiotensin-converting enzyme inhibitor, did not have a negative impact on mood in 12 normal subjects. It significantly reduced diastolic blood pressure and increased heart rate, potentially enhancing attention and alertness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Long-term enalapril--a new converting enzyme inhibitor--in the treatment of mild to moderate essential hypertension, results of a worldwide multiclinic study. Comparing two ways of analyzing data.

Author: LessemJ N, RucinskaE, VickersF F, EspieJ, SromovskyJ A

Attenuates thiazide-induced side effects
Effective for hypertension
Safe and well tolerated
Proteinuria
Rash

Enalapril, a converting enzyme inhibitor, effectively lowered both systolic and diastolic blood pressure in patients with mild to moderate essential hypertension. It was more effective than propranolol, and required less frequent addition of hydrochlorothiazide to achieve optimal blood pressure control. Enalapril was well-tolerated with minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Angiotensin converting enzyme during acute and chronic enalapril therapy in essential hypertension.

Author: JacksonB, JohnstonC I

ACE inhibition
Blood pressure reduction

Enalapril effectively reduced blood pressure in 12 subjects acutely and in 11 chronically. ACE inhibition correlated well with drug levels and hypotensive effects, suggesting induction of ACE during chronic treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Comparative effects of combination drug therapy regimens commencing with either losartan potassium, an angiotensin II receptor antagonist, or enalapril maleate for the treatment of severe hypertension.

Author: RuffD, GazdickL P, BermanR, GoldbergA I, SweetC S

Effective blood pressure reduction
Well tolerated
Headache

Losartan-based regimen effectively lowered blood pressure, was generally well tolerated, and was generally similar to the enalapril-based regimen in the treatment of patients with severe hypertension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

[Enalapril-clinical experience in Bulgaria].

Author: TasevaT

Hypertension treatment
Cough

Enalapril, an ACE inhibitor, effectively reduces blood pressure and has good tolerability in patients with arterial hypertension. The most common side effects are headache, dizziness, and orthostatic effects. Dry cough occurs in approximately 8.6% of patients.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : Bulgarian

10.

A randomized, controlled, multicenter study to compare prazosin GITS with enalapril in hypertensive patients with diabetes mellitus. Bombay Hypertension Study Group.

Author: JoglekarS J, NanivadekarA S

Hypertension treatment
Lipid lowering

Prazosin GITS and enalapril were both effective in controlling hypertension in patients with diabetes mellitus. A randomized, controlled study involving 89 patients found that both drugs effectively lowered blood pressure. Prazosin GITS had a beneficial effect on serum triglycerides, while enalapril had a favorable effect on triglycerides but a detrimental effect on LDL cholesterol. Both drugs increased fasting blood sugar and 2-hour post-meal blood sugar levels, but this was more significant in the prazosin GITS group. Prazosin GITS was also associated with fewer adverse events compared to enalapril.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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