Effective treatment of food allergy: A Synthesis of Findings from 25 Studies

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Original Abstract of the Article

Major Research Findings

Research on treatments for food allergies has shown that immunotherapy is a promising option, in addition to food avoidance. 14 suggests that immunotherapy, such as oral immunotherapy (OIT) and sublingual immunotherapy (SLIT), can be effective, particularly when avoiding food allergens is challenging. OIT works by gradually introducing small amounts of the allergenic food to re-educate the immune system and reduce allergic reactions. 11 , 19 , 18 , 17 , 23 are studies that examined the efficacy and safety of OIT for various food allergies. These studies demonstrate that OIT can be effective for a range of food allergies, including egg allergy, cow's milk allergy, and peanut allergy. 5 demonstrates the effectiveness of sublingual immunotherapy for hazelnut allergy. However, OIT also has been reported to carry a risk of side effects. 15 points out that allergic reactions can occur as a side effect of OIT. Moreover, there is a possibility of allergic reactions recurring when OIT is discontinued. 17 mentions the recurrence of allergic reactions after discontinuing OIT. Furthermore, the effectiveness of OIT varies among individuals, and long-term benefits may not be achieved in all cases. 13 suggests that OIT may not always have lasting effects.

The use of biologicals is also being researched as a new treatment approach for food allergies. 24 mentions the potential of biologicals to help treat IgE-mediated food allergies. Biologicals target specific components of the immune system that are involved in allergic reactions, aiming to suppress these reactions.

Adjusting the gut microbiota is also gaining attention as a new treatment strategy for food allergies. 25 , 21 , 12 are researching the potential of probiotics and genetically modified probiotics to adjust the gut microbiota and prevent or treat food allergies. These studies suggest that probiotics may help suppress food allergies by improving the balance of the gut microbiota and regulating immune system functions.

Treatment Summary

Research is being conducted on a variety of treatments for food allergies, including food avoidance, OIT, SLIT, biologicals, and probiotics. OIT has shown effectiveness for various food allergies, but challenges exist, such as the risk of side effects and individual variations in response. SLIT has demonstrated effectiveness for hazelnut allergy. Biologicals hold potential for treating IgE-mediated food allergies, and probiotics could potentially suppress food allergies by adjusting the gut microbiota.

Benefits and Risks

Benefit Summary

Immunotherapy is considered a promising treatment for food allergies. OIT has shown effectiveness for various food allergies. SLIT has demonstrated effectiveness for hazelnut allergy. Biologicals and probiotics are also gaining attention as new treatment strategies for food allergies.

Risk Summary

OIT carries a risk of side effects, such as allergic reactions. There is also a possibility of allergic reactions recurring when OIT is discontinued. The effectiveness of OIT varies among individuals, and long-term benefits may not be achieved in all cases.

Comparison Between Studies

Commonalities in Studies

Many studies commonly focus on OIT as a promising treatment approach for food allergies. They also note that the effectiveness of OIT can vary among individuals and that long-term benefits may not always be achieved.

Differences Between Studies

Studies vary in the types of food allergies investigated, the methods used for OIT, and the research designs.

Consistency and Inconsistencies in Results

While the effectiveness of OIT has been demonstrated in many studies, results vary regarding the risk of side effects and the duration of effectiveness.

Cautions for Applying Results to Real Life

Although OIT is a promising option for treating food allergies, it is important to be aware of risks such as side effects and individual differences in response. It is crucial to consult with a doctor before starting OIT to fully understand the risks and benefits.

Current Limitations in Research

Further research is needed to understand the long-term effectiveness of OIT and determine optimal treatment approaches. Additionally, development of new treatment options, such as biologicals and probiotics, is needed.

Future Research Directions

Research is needed to clarify the long-term effectiveness of OIT and determine the optimal treatment approach. It is also important to develop new treatment methods, such as biologicals and probiotics. Additionally, investigating the underlying mechanisms of food allergy development could lead to more effective prevention and treatment approaches.

Conclusion

Research on food allergy treatments highlights OIT as a promising option. However, OIT comes with challenges, such as the risk of side effects and individual variations in response. Development of various treatment methods, including OIT, alongside research into the mechanisms underlying food allergies, holds promise for future advancements in effective prevention and treatment approaches.

List of Treatments

Food avoidance, OIT, SLIT, biologicals, probiotics

Literature analysis of 25 papers
Positive Content
24
Neutral Content
0
Negative Content
1
Article Type
17
3
8
6
25
1.

Evaluation of immune complexes after immunotherapy with wheat flour in bakers' asthma.

Author: ArmentiaA, ArranzM, MartinJ M, de la FuenteR, SanchezP, BarberD, SalcedoG, BlancoA

Hyposensitization
Immune complex

A study of 26 patients with baker's asthma investigated the effectiveness and safety of immunotherapy with wheat flour. The study also looked for the presence of circulating immune complexes (CICs) after two years of treatment. The study aims to provide evidence for the use of immunotherapy for inhalant food allergies and to evaluate the potential role of CICs in any adverse reactions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Blind food challenge testing with wide-open eyes.

Author: BahnaS L

Improved food allergy diagnosis

The most accurate way to confirm a food allergy is through a double-blind, placebo-controlled challenge test. However, single-blind testing is often sufficient in routine clinical practice. Open challenge testing may be acceptable for young children or less likely foods. It is important to avoid challenge tests when the food has caused a life-threatening reaction. Care should be taken in planning, conducting, and interpreting these tests to ensure accuracy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Food allergy in children: results of a standardized protocol for oral desensitization.

Author: PatriarcaG, SchiavinoD, NuceraE, SchincoG, MilaniA, GasbarriniG B

Improved food allergy treatment

This paper proposes a standardized treatment program for food allergies in children, using oral desensitization. The authors note that food allergies in children are a challenging issue, particularly when the food is essential for growth. Existing research on desensitization treatments is limited and inconsistent. This new protocol aims to provide a more structured approach to helping children with food allergies.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Oral desensitizing treatment in food allergy: clinical and immunological results.

Author: PatriarcaG, NuceraE, RoncalloC, PollastriniE, BartolozziF, De PasqualeT, BuonomoA, GasbarriniG, Di CampliC, SchiavinoD

Food allergy treatment
Mild side effects

Oral desensitization in food allergy patients showed promising results in a study of 59 patients. The majority successfully completed the treatment, with mild side effects easily managed with antihistamines or sodium cromolyn. Significant decreases in specific immunoglobulin E and increases in specific immunoglobulin G4 were observed, suggesting potential for oral tolerance mediated by similar mechanisms as traditional desensitization treatments for respiratory allergies.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Sublingual immunotherapy for hazelnut food allergy: a randomized, double-blind, placebo-controlled study with a standardized hazelnut extract.

Author: EnriqueErnesto, PinedaFernando, MalekTamim, BartraJoan, BasagañaMaría, TellaRaquel, CastellóJosé Vicente, AlonsoRosario, de MateoJosé Antonio, Cerdá-TriasTeresa, San Miguel-MoncínMaría del Mar, MonzónSusana, GarcíaMaría, PalaciosRicardo, Cisteró-BahímaAnna

Hazelnut allergy treatment
Increased tolerance to hazelnut
Systemic reactions

Sublingual immunotherapy with a standardized hazelnut extract was effective in increasing tolerance to hazelnut in patients allergic to hazelnut. The mean hazelnut quantity provoking objective symptoms increased from 2.29 g to 11.56 g (P=.02) in the active group versus 3.49 g to 4.14 g (placebo). This treatment was well-tolerated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Acute allergic reactions in children with AEDS after prolonged cow's milk elimination diets.

Author: FlintermanA E, KnulstA C, MeijerY, Bruijnzeel-KoomenC A F M, PasmansS G M A

Allergic reactions to cow's milk

Children with atopic eczema dermatitis syndrome (AEDS) who were on a cow's milk (CM) elimination diet for a median of 2.3 years were found to have a high chance of developing acute allergic reactions to CM after accidental ingestion during the elimination period. Double-blind placebo-controlled food challenge (DBPCFC) revealed that all 11 children experienced acute allergic reactions to CM, despite having no previous problems with CM intake before the elimination period.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Egg oral immunotherapy in nonanaphylactic children with egg allergy.

Author: BuchananAriana D, GreenTodd D, JonesStacie M, ScurlockAmy M, ChristieLynn, AlthageKaren A, SteelePamela H, PonsLaurent, HelmRick M, LeeLaurie A, BurksA Wesley

Safe for egg allergy

Oral immunotherapy (OIT) for egg allergy was safe and did not heighten sensitivity to egg.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction.

Author: StadenU, Rolinck-WerninghausC, BreweF, WahnU, NiggemannB, BeyerK

Increased tolerance threshold
Allergic reactions

Specific oral tolerance induction (SOTI) showed promise as a treatment for persistent food allergies, with 36% of children developing permanent tolerance to cow's milk or hen's egg allergy. While elimination diets also led to tolerance in some cases, SOTI offered the advantage of a higher threshold dose for allergic reactions and reduced risk of severe reactions after accidental ingestion. However, careful monitoring during SOTI is crucial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Specific oral tolerance induction for food. A systematic review.

Author: CalvaniM, GiorgioV, Miceli SopoS

Accelerated tolerance development
Adverse events

This systematic review examined the efficacy and safety of specific oral tolerance induction (SOTI) for treating persistent food allergy. Six randomized controlled trials (RCTs) met the inclusion criteria. SOTI showed promise in accelerating the development of tolerance, but more research is needed to optimize treatment protocols and reduce adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Oral and sublingual immunotherapy for egg allergy.

Author: RomantsikOlga, BruschettiniMatteo, ToscaMaria Angela, ZappettiniSimona, Della Casa AlberighiOrnella, CalevoMaria Grazia

Desensitization to egg allergen
Adverse effects
Epinephrine use

Oral immunotherapy (OIT) for egg allergy was found to be effective in desensitizing a large number of egg-allergic patients. Thirty-nine percent of OIT participants could tolerate a full serving of egg compared to 11.9% of the control group. However, OIT was associated with a high frequency of mild-to-severe adverse effects, with 69% of participants experiencing such effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Administration of a probiotic with peanut oral immunotherapy: A randomized trial.

Author: TangMimi L K, PonsonbyAnne-Louise, OrsiniFrancesca, TeyDean, RobinsonMarnie, SuEe Lyn, LicciardiPaul, BurksWesley, DonathSusan

Improved peanut allergy
Adverse events

This study found that a combined therapy of probiotics and peanut oral immunotherapy (OIT) was effective in inducing possible sustained unresponsiveness and immune changes that suggest modulation of the peanut-specific immune response. 82.1% of children receiving the combined therapy achieved sustained unresponsiveness compared to 3.6% of children receiving placebo. The combined therapy was associated with a greater number of adverse events, mostly with maintenance home dosing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Oral Immunotherapy for Egg Allergy: A Double-Blind Placebo-Controlled Study, with Postdesensitization Follow-Up.

Author: CaminitiLucia, PajnoGiovanni B, CrisafulliGiuseppe, ChieraFernanda, ColluraMirella, PanasciGirolamo, RuggeriPaolo, GuglielmoFrancesco, PassalacquaGiovanni

Food allergy treatment

Oral immunotherapy (OIT) is a potential treatment for food allergies in children. It's unclear whether OIT simply makes the body less sensitive to the food (desensitization), which would require continued exposure, or whether it leads to true tolerance, where the ability to eat the food would remain even after stopping treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Immunotherapy (oral and sublingual) for food allergy to fruits.

Author: Yepes-NuñezJuan Jose, ZhangYuan, Roqué i FigulsMarta, Bartra TomasJoan, ReyesJuan Manuel, Pineda de la LosaFernando, EnriqueErnesto

Food allergy treatment
Anaphylaxis risk

Food allergy is an immune system reaction to food. The main treatment is avoiding the allergen, including fruits. Accidental exposure can cause severe reactions. Allergen-specific immunotherapy (SIT) is an option for people who can't avoid the allergen. Recent research focuses on oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) to treat food allergies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy.

Author: WoodRobert A, KimJennifer S, LindbladRobert, NadeauKari, HenningAlice K, DawsonPeter, PlautMarshall, SampsonHugh A

Reduced allergic reactions

A double-blind, placebo-controlled trial of 57 children with milk allergy found that omalizumab significantly reduced treatment-related adverse reactions during oral immunotherapy (OIT) but did not improve desensitization or sustained unresponsiveness (SU) outcomes. Omalizumab-treated subjects experienced fewer dose-related reactions requiring treatment and needed fewer doses to achieve maintenance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

16.

Does atopic dermatitis cause food allergy? A systematic review.

Author: TsakokTeresa, MarrsTom, MohsinMahrose, BaronSusannah, du ToitGeorge, TillStephen, FlohrCarsten

Atopic dermatitis (AD) is strongly associated with food allergy (FA), with a prevalence of food sensitization up to 6 times higher in AD patients compared to healthy controls. FA is also associated with a more severe AD phenotype, earlier onset, and increased persistence. Evidence suggests that AD may precede the development of FA, supporting a causal relationship.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective.

Author: VickeryBrian P, BerglundJelena P, BurkCaitlin M, FineJason P, KimEdwin H, KimJung In, KeetCorinne A, KulisMichael, OrgelKelly G, GuoRishu, SteelePamela H, VirkudYamini V, YePing, WrightBenjamin L, WoodRobert A, BurksA Wesley

Peanut allergy treatment
Reduced peanut-specific IgE
Allergic side effects

Early oral immunotherapy (E-OIT) was found to be safe, effective, and feasible in treating peanut allergy in children aged 9 to 36 months. The study enrolled 40 children with suspected or known peanut allergy who were randomized to receive E-OIT at maintenance doses of 300 or 3000 mg/d. A high proportion of children achieved sustained unresponsiveness, with significant declines in peanut-specific IgE levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Randomized controlled trial of oral immunotherapy for egg allergy in Japanese patients.

Author: AkashiMasayuki, YasudoHiroki, NaritaMasami, NomuraIchiro, AkasawaAkira, EbisawaMotohiro, TakahashiTakao, OhyaYukihiro

Egg allergy treatment

Egg allergy is common in young children. While oral immunotherapy (OIT) isn't typically recommended, it's being explored as a possible treatment. While there are studies on OIT for food allergies, no controlled trials have been conducted in Japan.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Oral and sublingual immunotherapy for egg allergy.

Author: RomantsikOlga, ToscaMaria Angela, ZappettiniSimona, CalevoMaria Grazia

Complete recovery
Increased tolerance
Mild-to-severe adverse events
Serious allergic reactions

Oral immunotherapy is an effective treatment for egg allergy in children, although it is associated with a high rate of adverse events. Most children receiving oral immunotherapy were able to ingest a partial serving of egg and almost half were able to tolerate a full serving of egg, compared to a minority of control group children. However, nearly all children who received oral immunotherapy experienced adverse events, including serious allergic reactions requiring epinephrine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Skin Care and Synbiotics for Prevention of Atopic Dermatitis or Food Allergy in Newborn Infants: A 2 × 2 Factorial, Randomized, Non-Treatment Controlled Trial.

Author: DissanayakeEishika, TaniYumi, NagaiKazue, SaharaMasumi, MitsuishiChisako, TogawaYaei, SuzukiYoichi, NakanoTaiji, YamaideFumiya, OhnoHiroshi, ShimojoNaoki

Improved gut
Improved skin

There is no conclusive evidence on the use of emollients and synbiotics alone or in combination to treat atopic dermatitis (AD) and food allergy (FA).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Effects of probiotics in the treatment of food hypersensitivity in children: a systematic review.

Author: SantosStephanie Campos Dos, KonstantynerTulio, CoccoRenata Rodrigues

Improved gut health
Reduced allergy symptoms

A systematic review of 18 clinical trials using probiotics in pediatric food hypersensitivity treatment showed that probiotics were beneficial in promoting immunomodulation and reducing clinical symptoms. The most commonly used strain was Lactobacillus rhamnosus GG.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

The Montelukast Therapy in Asthmatic Children with and without Food Allergy: Does It Make Any Difference?

Author: SahinerUmit Murat, Arik YilmazEbru, FontanellaSara, HaiderSadia, SoyerOzge, CustovicAdnan, KalayciOmer, SackesenCansin

Antileukotriene treatment for asthmatic children with food allergy

This study investigates the potential benefits of antileukotriene treatment for asthmatic children with food allergies. Leukotrienes play a role in both asthma and food allergies, suggesting that antileukotriene therapy may be beneficial for this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Efficacy and safety of baked milk oral immunotherapy in children with severe milk allergy: A randomized, double-blind, placebo-controlled phase 2 trial.

Author: DantzerJennifer, DunlopJoan, PsoterKevin J, KeetCorinne, WoodRobert

Desensitization
Dose-related reactions

Baked milk oral immunotherapy (BMOIT) was well tolerated and induced a substantial level of desensitization in children allergic to baked milk, with 73% of participants tolerating 4044 mg of baked milk protein after 12 months.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Biologicals in IgE-mediated food allergy.

Author: MutarelliAntonio, Giavina-BianchiBruna, ArasiStefania, CafarottiArianna, FiocchiAlessandro

Effective for food allergy

Omalizumab is a safe and effective treatment for IgE-mediated food allergy. A systematic review and meta-analysis showed that omalizumab can be used as a monotherapy or as an adjunct to oral immunotherapy in IgE-mediated cow's milk allergy. Further research is needed to evaluate other potential biologic therapies for food allergy.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

25.

Probiotics and the Potential of Genetic Modification as a Possible Treatment for Food Allergy.

Author: WeiYuqiu, PengJing, WangSiyu, DingZheng, ChenGuixi, SunJiazeng

Food allergy treatment

Food allergy affects millions worldwide and is caused by an abnormal immune response to food antigens. Probiotics, including genetically modified probiotics, have emerged as a potential strategy for preventing and treating food allergies by modulating the gut microbiota and immune system. This systematic review summarizes the current evidence for the role of probiotics in food allergy and suggests future research directions.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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