Effective treatment of food labeling: A Synthesis of Findings from 25 Studies

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Original Abstract of the Article

Major research findings

The treatment of food allergy has traditionally focused on avoiding the offending food, but immunotherapy with food is emerging as a new therapeutic option. 14 This approach aims to desensitize individuals to the allergen by gradually introducing it in controlled amounts, potentially allowing them to consume the food without experiencing severe reactions. 14 , 5 , 11 , 18 , 19 Research suggests that oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) can be effective for treating allergies to various foods, including eggs, milk, peanuts, and hazelnuts. 11 , 13 , 17 , 19 , 23 These therapies have shown promise in increasing tolerance to allergens and reducing allergic symptoms. 13 , 17 , 23 However, it's important to note that OIT and SLIT are not without challenges. They can be associated with adverse reactions, and the benefits may diminish when treatment is discontinued. 15 , 17 , 23 The effectiveness of these therapies can also vary between individuals and allergens. 15 , 17 , 23 Some research suggests that combining OIT or SLIT with other interventions, such as probiotics, might enhance the treatment's effectiveness. 12 , 25 These findings highlight the potential for modulating the gut microbiota and immune system to improve outcomes in food allergy management. 12 , 25

Treatment Summary

Traditional food allergy management has relied heavily on allergen avoidance. However, recent research has focused on developing alternative treatments using food immunotherapy. 14 , 5 , 11 , 18 , 19 Oral immunotherapy (OIT) involves gradually increasing the amount of the allergen consumed over time, aiming to desensitize the individual. 11 , 13 , 17 , 19 , 23 Sublingual immunotherapy (SLIT) involves placing the allergen under the tongue, where it is absorbed into the bloodstream. 14 , 5 While these immunotherapies show promise, challenges exist, including the risk of allergic reactions and the potential for tolerance loss upon treatment cessation. 15 , 17 , 23 Furthermore, OIT and SLIT effectiveness varies between individuals and allergens. 15 , 17 , 23 Research is ongoing to explore the potential of combining OIT or SLIT with other approaches, such as probiotics, to enhance their effectiveness. 12 , 25 This research suggests that modulating the gut microbiota and immune system may play a crucial role in improving food allergy management. 12 , 25

Benefits and Risks

Benefit Summary

Food immunotherapy, specifically OIT and SLIT, holds the potential to desensitize individuals to food allergens, potentially enabling them to consume the offending food without experiencing severe reactions. 14 , 5 , 11 , 18 , 19 Research indicates that these therapies can increase tolerance to allergens and reduce allergic symptoms. 13 , 17 , 23 Furthermore, combining these therapies with probiotics or other immune modulators may enhance their effectiveness. 12 , 25

Risk Summary

While promising, food immunotherapy is associated with potential risks. These include allergic reactions during treatment and a potential loss of tolerance if treatment is discontinued. 15 , 17 , 23 It's essential to note that the effectiveness of OIT and SLIT can vary based on the individual and the specific allergen involved. 15 , 17 , 23

Comparison between Studies

Similarities between Studies

Multiple studies indicate that OIT and SLIT have the potential to be effective treatments for food allergy. 11 , 13 , 17 , 18 , 19 These therapies have been shown to improve tolerance to allergens and reduce symptoms. 13 , 17 , 23 However, they also share some drawbacks, including the risk of allergic reactions and the possibility of tolerance loss when treatment is stopped. 15 , 17 , 23

Differences between Studies

The studies differ in their focus on specific food allergies, the types of immunotherapy used, and the duration of treatment. 11 , 13 , 17 , 18 , 19 The research findings also vary in terms of treatment efficacy and the frequency of allergic reactions. 15 , 17 , 23

Consistency and Contradictions in Results

While multiple studies suggest the potential effectiveness of OIT and SLIT in treating food allergy, it's crucial to acknowledge that these therapies are not without challenges. 15 , 17 , 23 The effectiveness of OIT and SLIT can vary based on the individual and the specific allergen. 15 , 17 , 23 Therefore, more in-depth data collection and research involving a larger patient pool are needed to further understand the full spectrum of these therapies' impact.

Considerations for Real-World Application

While promising, OIT and SLIT present challenges, including the risk of allergic reactions and potential tolerance loss after treatment cessation. 15 , 17 , 23 If considering these therapies, close monitoring and guidance from a qualified healthcare professional are crucial. 15 , 17 , 23 It's important to remember that OIT and SLIT are not universally effective, and individual responses can vary. 15 , 17 , 23 Consulting with a healthcare professional before starting treatment is crucial for personalized care and informed decision-making.

Current Research Limitations

Existing research limitations include the fact that the effectiveness of OIT and SLIT is not consistent across all individuals. 15 , 17 , 23 The long-term efficacy and safety of these therapies also require further investigation. 15 , 17 , 23 Additional research is essential to comprehensively understand the full impact of OIT and SLIT on food allergy management.

Future Research Directions

Future research should focus on delving deeper into the effectiveness of OIT and SLIT. 15 , 17 , 23 Key areas of inquiry include the duration of treatment effectiveness, the types of individuals who benefit most, and potential risks associated with these therapies. 15 , 17 , 23 Further research into strategies for enhancing the effectiveness of OIT and SLIT, such as combining them with probiotics or other immune modulators, is also crucial. 12 , 25 These endeavors aim to develop safer and more effective treatments for food allergy.

Conclusion

Food immunotherapy, particularly OIT and SLIT, shows promise in managing food allergy, but it's essential to acknowledge the challenges they present, such as allergic reactions and the potential for tolerance loss upon treatment cessation. 15 , 17 , 23 If considering these therapies, close monitoring and guidance from a qualified healthcare professional are paramount. 15 , 17 , 23 As research continues to advance, we can anticipate the development of safer and more effective treatment options for individuals with food allergies.

Treatment List

Oral immunotherapy (OIT)

Sublingual immunotherapy (SLIT)

Probiotics

Immune modulators

Literature analysis of 25 papers
Positive Content
24
Neutral Content
0
Negative Content
1
Article Type
17
3
8
6
25
1.

Evaluation of immune complexes after immunotherapy with wheat flour in bakers' asthma.

Author: ArmentiaA, ArranzM, MartinJ M, de la FuenteR, SanchezP, BarberD, SalcedoG, BlancoA

Hyposensitization
Immune complex

A study of 26 patients with baker's asthma investigated the effectiveness and safety of immunotherapy with wheat flour. The study also looked for the presence of circulating immune complexes (CICs) after two years of treatment. The study aims to provide evidence for the use of immunotherapy for inhalant food allergies and to evaluate the potential role of CICs in any adverse reactions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Blind food challenge testing with wide-open eyes.

Author: BahnaS L

Improved food allergy diagnosis

The most accurate way to confirm a food allergy is through a double-blind, placebo-controlled challenge test. However, single-blind testing is often sufficient in routine clinical practice. Open challenge testing may be acceptable for young children or less likely foods. It is important to avoid challenge tests when the food has caused a life-threatening reaction. Care should be taken in planning, conducting, and interpreting these tests to ensure accuracy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Food allergy in children: results of a standardized protocol for oral desensitization.

Author: PatriarcaG, SchiavinoD, NuceraE, SchincoG, MilaniA, GasbarriniG B

Improved food allergy treatment

This paper proposes a standardized treatment program for food allergies in children, using oral desensitization. The authors note that food allergies in children are a challenging issue, particularly when the food is essential for growth. Existing research on desensitization treatments is limited and inconsistent. This new protocol aims to provide a more structured approach to helping children with food allergies.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Oral desensitizing treatment in food allergy: clinical and immunological results.

Author: PatriarcaG, NuceraE, RoncalloC, PollastriniE, BartolozziF, De PasqualeT, BuonomoA, GasbarriniG, Di CampliC, SchiavinoD

Food allergy treatment
Mild side effects

Oral desensitization in food allergy patients showed promising results in a study of 59 patients. The majority successfully completed the treatment, with mild side effects easily managed with antihistamines or sodium cromolyn. Significant decreases in specific immunoglobulin E and increases in specific immunoglobulin G4 were observed, suggesting potential for oral tolerance mediated by similar mechanisms as traditional desensitization treatments for respiratory allergies.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Sublingual immunotherapy for hazelnut food allergy: a randomized, double-blind, placebo-controlled study with a standardized hazelnut extract.

Author: EnriqueErnesto, PinedaFernando, MalekTamim, BartraJoan, BasagañaMaría, TellaRaquel, CastellóJosé Vicente, AlonsoRosario, de MateoJosé Antonio, Cerdá-TriasTeresa, San Miguel-MoncínMaría del Mar, MonzónSusana, GarcíaMaría, PalaciosRicardo, Cisteró-BahímaAnna

Hazelnut allergy treatment
Increased tolerance to hazelnut
Systemic reactions

Sublingual immunotherapy with a standardized hazelnut extract was effective in increasing tolerance to hazelnut in patients allergic to hazelnut. The mean hazelnut quantity provoking objective symptoms increased from 2.29 g to 11.56 g (P=.02) in the active group versus 3.49 g to 4.14 g (placebo). This treatment was well-tolerated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Acute allergic reactions in children with AEDS after prolonged cow's milk elimination diets.

Author: FlintermanA E, KnulstA C, MeijerY, Bruijnzeel-KoomenC A F M, PasmansS G M A

Allergic reactions to cow's milk

Children with atopic eczema dermatitis syndrome (AEDS) who were on a cow's milk (CM) elimination diet for a median of 2.3 years were found to have a high chance of developing acute allergic reactions to CM after accidental ingestion during the elimination period. Double-blind placebo-controlled food challenge (DBPCFC) revealed that all 11 children experienced acute allergic reactions to CM, despite having no previous problems with CM intake before the elimination period.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Egg oral immunotherapy in nonanaphylactic children with egg allergy.

Author: BuchananAriana D, GreenTodd D, JonesStacie M, ScurlockAmy M, ChristieLynn, AlthageKaren A, SteelePamela H, PonsLaurent, HelmRick M, LeeLaurie A, BurksA Wesley

Safe for egg allergy

Oral immunotherapy (OIT) for egg allergy was safe and did not heighten sensitivity to egg.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction.

Author: StadenU, Rolinck-WerninghausC, BreweF, WahnU, NiggemannB, BeyerK

Increased tolerance threshold
Allergic reactions

Specific oral tolerance induction (SOTI) showed promise as a treatment for persistent food allergies, with 36% of children developing permanent tolerance to cow's milk or hen's egg allergy. While elimination diets also led to tolerance in some cases, SOTI offered the advantage of a higher threshold dose for allergic reactions and reduced risk of severe reactions after accidental ingestion. However, careful monitoring during SOTI is crucial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Specific oral tolerance induction for food. A systematic review.

Author: CalvaniM, GiorgioV, Miceli SopoS

Accelerated tolerance development
Adverse events

This systematic review examined the efficacy and safety of specific oral tolerance induction (SOTI) for treating persistent food allergy. Six randomized controlled trials (RCTs) met the inclusion criteria. SOTI showed promise in accelerating the development of tolerance, but more research is needed to optimize treatment protocols and reduce adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Oral and sublingual immunotherapy for egg allergy.

Author: RomantsikOlga, BruschettiniMatteo, ToscaMaria Angela, ZappettiniSimona, Della Casa AlberighiOrnella, CalevoMaria Grazia

Desensitization to egg allergen
Adverse effects
Epinephrine use

Oral immunotherapy (OIT) for egg allergy was found to be effective in desensitizing a large number of egg-allergic patients. Thirty-nine percent of OIT participants could tolerate a full serving of egg compared to 11.9% of the control group. However, OIT was associated with a high frequency of mild-to-severe adverse effects, with 69% of participants experiencing such effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Administration of a probiotic with peanut oral immunotherapy: A randomized trial.

Author: TangMimi L K, PonsonbyAnne-Louise, OrsiniFrancesca, TeyDean, RobinsonMarnie, SuEe Lyn, LicciardiPaul, BurksWesley, DonathSusan

Improved peanut allergy
Adverse events

This study found that a combined therapy of probiotics and peanut oral immunotherapy (OIT) was effective in inducing possible sustained unresponsiveness and immune changes that suggest modulation of the peanut-specific immune response. 82.1% of children receiving the combined therapy achieved sustained unresponsiveness compared to 3.6% of children receiving placebo. The combined therapy was associated with a greater number of adverse events, mostly with maintenance home dosing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Oral Immunotherapy for Egg Allergy: A Double-Blind Placebo-Controlled Study, with Postdesensitization Follow-Up.

Author: CaminitiLucia, PajnoGiovanni B, CrisafulliGiuseppe, ChieraFernanda, ColluraMirella, PanasciGirolamo, RuggeriPaolo, GuglielmoFrancesco, PassalacquaGiovanni

Food allergy treatment

Oral immunotherapy (OIT) is a potential treatment for food allergies in children. It's unclear whether OIT simply makes the body less sensitive to the food (desensitization), which would require continued exposure, or whether it leads to true tolerance, where the ability to eat the food would remain even after stopping treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Immunotherapy (oral and sublingual) for food allergy to fruits.

Author: Yepes-NuñezJuan Jose, ZhangYuan, Roqué i FigulsMarta, Bartra TomasJoan, ReyesJuan Manuel, Pineda de la LosaFernando, EnriqueErnesto

Food allergy treatment
Anaphylaxis risk

Food allergy is an immune system reaction to food. The main treatment is avoiding the allergen, including fruits. Accidental exposure can cause severe reactions. Allergen-specific immunotherapy (SIT) is an option for people who can't avoid the allergen. Recent research focuses on oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) to treat food allergies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy.

Author: WoodRobert A, KimJennifer S, LindbladRobert, NadeauKari, HenningAlice K, DawsonPeter, PlautMarshall, SampsonHugh A

Reduced allergic reactions

A double-blind, placebo-controlled trial of 57 children with milk allergy found that omalizumab significantly reduced treatment-related adverse reactions during oral immunotherapy (OIT) but did not improve desensitization or sustained unresponsiveness (SU) outcomes. Omalizumab-treated subjects experienced fewer dose-related reactions requiring treatment and needed fewer doses to achieve maintenance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

16.

Does atopic dermatitis cause food allergy? A systematic review.

Author: TsakokTeresa, MarrsTom, MohsinMahrose, BaronSusannah, du ToitGeorge, TillStephen, FlohrCarsten

Atopic dermatitis (AD) is strongly associated with food allergy (FA), with a prevalence of food sensitization up to 6 times higher in AD patients compared to healthy controls. FA is also associated with a more severe AD phenotype, earlier onset, and increased persistence. Evidence suggests that AD may precede the development of FA, supporting a causal relationship.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective.

Author: VickeryBrian P, BerglundJelena P, BurkCaitlin M, FineJason P, KimEdwin H, KimJung In, KeetCorinne A, KulisMichael, OrgelKelly G, GuoRishu, SteelePamela H, VirkudYamini V, YePing, WrightBenjamin L, WoodRobert A, BurksA Wesley

Peanut allergy treatment
Reduced peanut-specific IgE
Allergic side effects

Early oral immunotherapy (E-OIT) was found to be safe, effective, and feasible in treating peanut allergy in children aged 9 to 36 months. The study enrolled 40 children with suspected or known peanut allergy who were randomized to receive E-OIT at maintenance doses of 300 or 3000 mg/d. A high proportion of children achieved sustained unresponsiveness, with significant declines in peanut-specific IgE levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Randomized controlled trial of oral immunotherapy for egg allergy in Japanese patients.

Author: AkashiMasayuki, YasudoHiroki, NaritaMasami, NomuraIchiro, AkasawaAkira, EbisawaMotohiro, TakahashiTakao, OhyaYukihiro

Egg allergy treatment

Egg allergy is common in young children. While oral immunotherapy (OIT) isn't typically recommended, it's being explored as a possible treatment. While there are studies on OIT for food allergies, no controlled trials have been conducted in Japan.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Oral and sublingual immunotherapy for egg allergy.

Author: RomantsikOlga, ToscaMaria Angela, ZappettiniSimona, CalevoMaria Grazia

Complete recovery
Increased tolerance
Mild-to-severe adverse events
Serious allergic reactions

Oral immunotherapy is an effective treatment for egg allergy in children, although it is associated with a high rate of adverse events. Most children receiving oral immunotherapy were able to ingest a partial serving of egg and almost half were able to tolerate a full serving of egg, compared to a minority of control group children. However, nearly all children who received oral immunotherapy experienced adverse events, including serious allergic reactions requiring epinephrine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Skin Care and Synbiotics for Prevention of Atopic Dermatitis or Food Allergy in Newborn Infants: A 2 × 2 Factorial, Randomized, Non-Treatment Controlled Trial.

Author: DissanayakeEishika, TaniYumi, NagaiKazue, SaharaMasumi, MitsuishiChisako, TogawaYaei, SuzukiYoichi, NakanoTaiji, YamaideFumiya, OhnoHiroshi, ShimojoNaoki

Improved gut
Improved skin

There is no conclusive evidence on the use of emollients and synbiotics alone or in combination to treat atopic dermatitis (AD) and food allergy (FA).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Effects of probiotics in the treatment of food hypersensitivity in children: a systematic review.

Author: SantosStephanie Campos Dos, KonstantynerTulio, CoccoRenata Rodrigues

Improved gut health
Reduced allergy symptoms

A systematic review of 18 clinical trials using probiotics in pediatric food hypersensitivity treatment showed that probiotics were beneficial in promoting immunomodulation and reducing clinical symptoms. The most commonly used strain was Lactobacillus rhamnosus GG.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

The Montelukast Therapy in Asthmatic Children with and without Food Allergy: Does It Make Any Difference?

Author: SahinerUmit Murat, Arik YilmazEbru, FontanellaSara, HaiderSadia, SoyerOzge, CustovicAdnan, KalayciOmer, SackesenCansin

Antileukotriene treatment for asthmatic children with food allergy

This study investigates the potential benefits of antileukotriene treatment for asthmatic children with food allergies. Leukotrienes play a role in both asthma and food allergies, suggesting that antileukotriene therapy may be beneficial for this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Efficacy and safety of baked milk oral immunotherapy in children with severe milk allergy: A randomized, double-blind, placebo-controlled phase 2 trial.

Author: DantzerJennifer, DunlopJoan, PsoterKevin J, KeetCorinne, WoodRobert

Desensitization
Dose-related reactions

Baked milk oral immunotherapy (BMOIT) was well tolerated and induced a substantial level of desensitization in children allergic to baked milk, with 73% of participants tolerating 4044 mg of baked milk protein after 12 months.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Biologicals in IgE-mediated food allergy.

Author: MutarelliAntonio, Giavina-BianchiBruna, ArasiStefania, CafarottiArianna, FiocchiAlessandro

Effective for food allergy

Omalizumab is a safe and effective treatment for IgE-mediated food allergy. A systematic review and meta-analysis showed that omalizumab can be used as a monotherapy or as an adjunct to oral immunotherapy in IgE-mediated cow's milk allergy. Further research is needed to evaluate other potential biologic therapies for food allergy.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

25.

Probiotics and the Potential of Genetic Modification as a Possible Treatment for Food Allergy.

Author: WeiYuqiu, PengJing, WangSiyu, DingZheng, ChenGuixi, SunJiazeng

Food allergy treatment

Food allergy affects millions worldwide and is caused by an abnormal immune response to food antigens. Probiotics, including genetically modified probiotics, have emerged as a potential strategy for preventing and treating food allergies by modulating the gut microbiota and immune system. This systematic review summarizes the current evidence for the role of probiotics in food allergy and suggests future research directions.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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