Effective treatment of genital warts: A Synthesis of Findings from 32 Studies

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Original Abstract of the Article

Major Research Findings

Genital warts, also known as condylomata acuminata, are a common sexually transmitted infection caused by the human papillomavirus (HPV). While there is no universally effective treatment for genital warts, various methods have been studied and are used in practice. These include ablative treatments like cryotherapy, electrocautery, and laser therapy, as well as topical therapies like podophyllin, imiquimod, and sinecatechins.

Research has shown that a combination of ablative and self-administered therapies might be more effective than ablative therapy alone in achieving sustained complete clearance of genital warts. 26 However, the specific combination and its effectiveness may vary depending on the individual.

Cryotherapy, a common treatment, has been shown to be effective in clearing genital warts in non-immunocompromised adults. 20 While it is an acceptable first-line treatment, it might have associated side effects like erythema, stinging, irritation, and pain.

In men with genital warts, a combination therapy of podophyllotoxin and cryotherapy showed significantly higher efficacy compared to monotherapy with either treatment. 25 This combination therapy also showed a significantly lower recurrence rate compared to cryotherapy alone.

Treatment Summary

A study 25 showed that a combination therapy of podophyllotoxin and cryotherapy was more effective than monotherapy with either treatment in men with genital warts. The study also found that the combination therapy had a significantly lower recurrence rate compared to cryotherapy alone.

The study 22 explored the effectiveness of different treatments, including imiquimod and podophyllotoxin creams, for genital warts.

A review of several studies 18 examined the effectiveness and cost-effectiveness of various treatments for anogenital warts, including cryotherapy, podophyllin, imiquimod, sinecatechins, interferon alfa, and 5-fluorouracil.

The effectiveness of 5-fluorouracil (5-FU) cream for treating genital warts was evaluated in 14 . The study found that 5-FU was more effective than placebo or no treatment, meta-cresol-sulfonic acid, and podophyllin, but it was less effective than 5-FU in combination with high-dose interferon alfa-2a or a combination of 5-FU, CO2 laser, and high-dose interferon alfa-2a.

A study 30 found that 5-aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) was the most effective treatment for urethral condylomas, leading to the lowest recurrence rate and the highest clearance rate compared to laser therapy and topical therapy, though with a higher risk of adverse events.

Benefits and Risks

Benefit Summary

The benefits of treating genital warts include the removal or reduction of visible lesions, the prevention of recurrence, and improvements in the patient's quality of life.

Risk Summary

Potential risks associated with genital wart treatments include pain, redness, swelling, blisters, bleeding, scarring, and pigmentation changes. These risks can vary depending on the specific treatment method and the individual's health condition. Consulting a doctor and understanding the benefits and risks of different treatment options is crucial before starting any treatment.

Comparison Between Studies

Commonalities

Many studies investigate the effectiveness of various treatments for genital warts, including cryotherapy, electrocautery, podophyllin, imiquimod, and interferon alpha.

Differences

Studies often vary in terms of the specific treatment methods, patient populations, and the duration of follow-up. Consequently, the effectiveness and safety profiles of different treatments can vary between studies.

Consistency and Contradictions in Results

There is a degree of inconsistency in the results across different studies. For example, some studies show that podophyllin is effective, while others do not. Similarly, some studies report low side effect rates with imiquimod, while others report higher rates. This variability could be due to factors such as individual patient characteristics, the size and location of lesions, and the specific treatment methods employed.

Practical Implications and Considerations

It's crucial to remember that research findings don't necessarily apply to everyone. The effectiveness and side effects of treatments can vary widely depending on individual factors. Additionally, research findings might not always reflect the latest treatment methods and medications. Therefore, seeking advice from a healthcare professional to discuss the latest treatments and their suitability for your specific situation is essential.

Limitations of Current Research

Current research on genital wart treatments has several limitations. Some studies have limited patient sample sizes, others have short follow-up periods, and there is a lack of standardization in research methods, making direct comparisons between studies difficult.

Future Research Directions

Future research on genital wart treatments should aim to include larger patient cohorts, conduct longer follow-up studies, and utilize standardized methodologies to improve the reliability and comparability of results. Further research is also needed to develop new, more effective, and safer treatment options.

Conclusion

Treating genital warts is an ongoing area of research. While there is no single, universally effective treatment, several options have been shown to be effective in some individuals. The specific treatment best suited for an individual depends on their health condition and other factors. Consult a healthcare professional to discuss the latest treatment options and to determine the best approach for your specific needs.

Treatment List

・Cryotherapy 20

・Electrocautery 2

・Podophyllin 3

・Imiquimod 10

・Interferon alpha 1

・5-fluorouracil (5-FU) 14

・Laser therapy 7

・Photodynamic Therapy (PDT) 30

Literature analysis of 32 papers
Positive Content
31
Neutral Content
1
Negative Content
0
Article Type
20
9
10
9
31
1.

Systemic interferon alpha-2b increases the cure rate in laser treated patients with multiple persistent genital warts: a placebo-controlled study.

Author: PetersenC S, BjerringP, LarsenJ, BlaakaerJ, HagdrupH, FromE, ObergaardL

Increased cure rate with interferon
Well tolerated
Chills
Fever
Headache
Leukopenia
Myalgia
Side effects

This study investigated the effectiveness of adding interferon-alpha 2b to laser treatment for persistent genital warts in 49 patients. The study found that interferon significantly increased the cure rate (52% vs 23%) compared to placebo. While interferon caused more side effects like fever, chills, and muscle aches, these were generally manageable, and only 3 out of 32 patients stopped treatment due to side effects. The study concludes that interferon-alpha 2b can be a helpful addition to laser treatment for resistant genital warts, improving cure rates despite potential side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Treatment of external genital warts: a randomised clinical trial comparing podophyllin, cryotherapy, and electrodesiccation.

Author: StoneK M, BeckerT M, HadguA, KrausS J

Cleared external genital warts
Relapses

A study of 450 patients with external genital warts found that electrodesiccation was the most effective treatment, followed by cryotherapy and podophyllin. None of the treatments were highly successful, with relapse rates of 25% across all patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Double-blind randomized clinical trial of self-administered podofilox solution versus vehicle in the treatment of genital warts.

Author: KirbyP, DunneA, KingD H, CoreyL

Safe and effective treatment for penile warts

This study evaluated the safety and effectiveness of podofilox in treating penile warts.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

Topical 0.3% and 0.5% podophyllotoxin cream for self-treatment of condylomata acuminata in women. A placebo-controlled, double-blind study.

Author: SyedT A, LundinS, AhmadS A

Improved understanding of genital warts

Genital warts are a common sexually transmitted infection that are different from skin warts. They are more common worldwide than previously thought. Women are more likely to be unaware of genital warts because they can be difficult to see.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Human leukocyte interferon-alpha versus podophyllotoxin in cream for the treatment of genital warts in males. A placebo-controlled, double-blind, comparative study.

Author: SyedT A, CheemaK M, KhayyamiM, AhmadS A, AhmadS H, AhmadS

Improved understanding of genital warts

Genital warts, a common sexually transmitted infection, have been increasing in recent years. These warts are caused by various types of human papillomaviruses (HPV), some of which are associated with the development of genital cancers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

The cost of treating genital warts.

Author: StraussM J, KhannaV, KoenigJ D, DownsS M, GoldbergS H, ManyakM J, PatsnerB

Improved genital warts treatment

This study compared the effectiveness, cost, and cost-effectiveness of five common treatments for genital warts. While current treatments provide temporary relief, they do not guarantee a long-term cure. The study reviewed medical literature, claims data, and consulted with experienced practitioners to assess the different treatment options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Treatment of genital HPV infection with carbon dioxide laser and systemic interferon alpha-2b.

Author: NieminenP, AhoM, LehtinenM, VesterinenE, VaheriA, PaavonenJ

Reduced recurrence

Adjuvant systemic interferon alpha-2b treatment following carbon dioxide laser ablation of genital HPV lesions was beneficial only for patients infected with HPV DNA 16/18.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Treatment of external genital warts in men using 5% imiquimod cream applied three times a week, once daily, twice daily, or three times a day.

Author: FifeK H, FerenczyA, DouglasJ M, BrownD R, SmithM, OwensM L,

Effective treatment of genital warts
Different response rates between men and women

Current treatments for genital warts are not always successful. Imiquimod cream, which stimulates the immune system, has been shown to be effective for treating genital warts in the genital and anal areas, but women are more likely to experience complete clearance of warts compared to men. About two-thirds of women clear their warts with imiquimod cream applied three times a week for up to 16 weeks, compared to only about one-third of men.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Efficacy and tolerability of topical 1% cidofovir cream for the treatment of external anogenital warts in HIV-infected persons.

Author: MatteelliA, BeltrameA, GraifemberghiS, ForleoM A, GullettaM, CiravoloG, TedoldiS, CasaliniC, CarosiG

Wart clearance
Mucosal erosion

Topical 1% cidofovir cream was found to be significantly more effective than vehicle cream for the initial clearance of anogenital warts in HIV-infected patients. However, local mucosal erosion was a common side effect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Topical imiquimod 5% cream as an effective treatment for external genital and perianal warts in different patient populations.

Author: SauderDaniel N, SkinnerRobert B, FoxTerry L, OwensMary L

Genital wart treatment

Imiquimod 5% cream proved to be an effective treatment for external genital and perianal warts, significantly superior to vehicle cream. The clearance rate was 50% for imiquimod versus 11% for vehicle. Imiquimod's effectiveness was consistent across subgroups based on gender, baseline wart area, duration of the outbreak, previous wart treatment, and tobacco use.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Meta-analysis of 5% imiquimod and 0.5% podophyllotoxin in the treatment of condylomata acuminata.

Author: YanJun, ChenSheng-Li, WangHai-Na, WuTai-Xiang

Genital warts treatment

The study compared the use of 0.5% podophyllotoxin and 5% imiquimod for the treatment of genital warts, highlighting the need for extensive and formal comparisons of these common topical agents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

13.

Interferon for the treatment of genital warts: a systematic review.

Author: YangJin, PuYu-Guo, ZengZhong-Ming, YuZhi-Jian, HuangNa, DengQi-Wen

This review assesses the efficacy and safety of interferon in curing genital warts based on randomized control trials (RCTs).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

5-FU for genital warts in non-immunocompromised individuals.

Author: BatistaClaudio S, AtallahAlvaro N, SaconatoHumberto, da SilvaEdina Mk

Improved cure rates

The study found that topical 5-Fluorouracil (5-FU) treatment for genital warts was more effective than placebo or no treatment, meta-cresol-sulfonic acid (MCSA), and Podophylin. However, 5-FU was less effective than 5-FU combined with INFalpha-2a (high dose) and 5-FU + CO2 Laser + Inf alpha-2a (high dose). Further studies are needed to determine the benefits and risks of topical 5-FU.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

A prospective, open, comparative study of 5% potassium hydroxide solution versus cryotherapy in the treatment of genital warts in men.

Author: CamargoCaio Lamunier de Abreu, Belda JuniorWalter, FagundesLuiz Jorge, RomitiRicardo

Genital wart treatment

Genital warts are caused by HPV and are a common sexually transmitted infection. While there's no treatment to eliminate HPV itself, most treatments focus on removing the warts. Potassium hydroxide, a strong alkali, has been shown to be safe and effective for genital warts. Cryotherapy is another common treatment. This study compares the effectiveness of potassium hydroxide and cryotherapy for genital warts.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Intralesional injection of Mycobacterium w vaccine vs imiquimod, 5%, cream in patients with anogenital warts: a randomized clinical trial.

Author: KumarPankaj, DarLalit, SaldiwalShashi, VarmaSangeeta, Datt UpadhyayAashish, TalwarDeepti, SharmaVinod Kumar, VermaKaushal Kumar, DwivediSada Nand, RajRama, GuptaSomesh

Complete resolution of warts
Reduced viral load
Anogenital warts

Imiquimod, 5%, and the Mw vaccine were equally effective in achieving clinical and virologic clearance for HPV-6. A significant decline in the HPV-11 viral load was achieved only with the Mw vaccine. Efficacy and safety of intralesional Mw vaccine is comparable to that of imiquimod, 5%, in treatment of AGWs.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Imiquimod for anogenital warts in non-immunocompromised adults.

Author: Grillo-ArdilaCarlos F, Angel-MüllerEdith, Salazar-DíazLuis C, GaitánHernando G, Ruiz-ParraAriel I, LethabyAnne

AGW treatment

Genital warts (AGW) can disappear on their own in about 30% of people, but there's no way to predict which warts will go away. Many treatment options exist, chosen based on doctor and patient preferences. Imiquimod, a medication applied by the patient, may offer advantages over treatments given by a doctor.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Clinical effectiveness and cost-effectiveness of interventions for the treatment of anogenital warts: systematic review and economic evaluation.

Author: ThurgarElizabeth, BartonSamantha, KarnerCharlotta, EdwardsSteven J

AGW treatment

Genital warts are caused by HPV and can be physically uncomfortable and emotionally distressing. While many treatments are available, there's limited evidence on their effectiveness and cost-effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Self-administered interventions for anogenital warts in immunocompetent patients: a systematic review and meta-analysis.

Author: WernerRicardo Niklas, WestfechtelLukas, DresslerCorinna, NastAlexander

Improved QoL
Wart clearance
Limited data
Local AE
Pain

This systematic review and meta-analysis evaluated the available evidence from randomized controlled trials (RCTs) on topical treatments for anogenital warts (AGWs). Imiquimod 3.75% and 5% cream, podophyllotoxin 0.5% solution and gel, and polyphenon E 10% and 15% ointment were superior to placebo in terms of complete clearance (CC).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Cryotherapy to treat anogenital warts in nonimmunocompromised adults: Systematic review and meta-analysis.

Author: BertolottiAntoine, DupinNicolas, BouscaratFabrice, MilpiedBrigitte, DerancourtChristian

Cryotherapy for AGWs
Adverse effects

This study compared the efficacy and safety of cryotherapy versus other anogenital wart (AGW) treatments. Cryotherapy efficacy did not appear to differ from that of other treatments, but was associated with more immediate low-level adverse events.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

The efficacy and safety of other cryotherapy compounds for the treatment of genital warts: a randomized controlled trial.

Author: FiroozA, HosseiniH, Izadi FirouzabadiL, Nassiri KashaniM, NasrollahiS A

Effective treatment
Wart reduction

The Wartner compound, a mixture of dimethyl ether and propane, was found to be as effective as liquid nitrogen in treating genital warts in male patients.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Human papillomavirus infection: protocol for a randomised controlled trial of imiquimod cream (5%) versus podophyllotoxin cream (0.15%), in combination with quadrivalent human papillomavirus or control vaccination in the treatment and prevention of recurrence of anogenital warts (HIPvac trial).

Author: MurrayMacey L, MeadowsJade, DoréCaroline J, CopasAndrew J, HaddowLewis J, LaceyCharles, JitMark, SoldanKate, BennettKate, TetlowMichelle, NathanMayura, GilsonRichard

Anogenital warts treatment
Cryotherapy
Topical agents
qHPV vaccination

Anogenital warts are a common sexually transmitted infection. About 90% are caused by HPV types 6 and 11, and half of cases are recurrences. The best treatment for anogenital warts is unclear. Common treatments include topical medications like podophyllotoxin or imiquimod, and freezing (cryotherapy). While the HPV vaccine prevents infection, it's unclear if it can also treat existing warts.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Topically applied treatments for external genital warts in nonimmunocompromised patients: a systematic review and network meta-analysis.

Author: JungJ M, JungC J, LeeW J, WonC H, LeeM W, ChoiJ H, ChangS E

External genital wart treatment
Adverse events

This study evaluated the efficacy and safety of topical treatments for external genital warts using a network meta-analysis. The results showed that podophyllotoxin 0.5% solution was significantly more efficacious than imiquimod 5% cream for lesion clearance, but it was associated with a higher adverse event rate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Clinical Efficacy of Combination Therapy with Podophyllotoxin and Liquid Nitrogen Cryotherapy in the Treatment of Genital Warts in Men.

Author: GolušinZoran, JovanovićMarina, MatićMilan, RošTatjana, VujanovićLjuba, NikolićOlivera

Lower recurrence
Reduced condyloma
Warts cleared

Combination therapy with podophyllotoxin and liquid nitrogen cryotherapy was more effective than either treatment alone for genital warts in men. After 6 weeks of treatment, the combination therapy led to a significantly higher clearance rate (P < 0.001) and a lower recurrence rate than cryotherapy alone over 6 months (P < 0.005).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

A systematic review evaluating the efficacy and safety of a combination of ablative treatment and self administered treatment versus ablative treatment alone for external anogenital warts.

Author: FengCheng, LiWei, WangXiaojun, ZhangHailin, SiLoubin, ChenZhixiong, BaiMing

Improved anogenital wart treatment

This review compares the efficacy of ablative therapy alone versus the combination of ablative therapy with self-administered treatment for achieving complete clearance of external anogenital warts.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Intralesional immunotherapy for the treatment of anogenital warts in pediatric population.

Author: NofalAhmad, AlakadRania

anogenital warts
intralesional immunotherapy

This study investigated the efficacy and safety of intralesional immunotherapy for treating multiple anogenital warts in children. The study found that both MMR vaccine and Candida antigen showed significantly better therapeutic response compared to saline. This suggests that intralesional immunotherapy is a promising and well-tolerated treatment option for anogenital warts in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

Topical and Systemic Retinoids for the Treatment of Genital Warts: A Systematic Review and Meta-Analysis.

Author: Oren-ShabtaiMeital, SnastIgor, LapidothMoshe, ShermanShany, NoymanYehonatan, MimouniDaniel, HodakEmmilia, LeviAssi

Genital warts treatment

Genital warts, caused by HPV, are a common sexually transmitted infection. They can go away on their own, but sometimes they persist. While many treatments exist, none can cure them completely, and they can come back. Retinoids, medications used for various skin problems, haven't been widely studied for treating genital warts.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Cryotherapy plus low-dose oral isotretinoin vs cryotherapy only for the treatment of anogenital warts: a randomized clinical trial.

Author: Reyna-RodríguezIrving Llibran, Chavez-AlvarezSonia, Garza-RodríguezVeronica, Franco-MarquezRodolfo, Gonzalez-MartinezGerardo, Ocampo-CandianiJorge, Villarreal-MartinezAlejandra

Cryotherapy for anogenital warts
Emotional distress
Variable retinoid results

This study discussed the use of retinoids (isotretinoin) as adjuvant therapy for anogenital warts, considering the effectiveness of cryotherapy as a first-line treatment and the variable results reported for retinoids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

30.

The place of 5-aminolaevulinic acid-photodynamic therapy in the treatment landscape of urethral warts: A systematic review.

Author: KechichianElio, HelouElie, SarkisJulien, HayekClaude, LabakiChris, NemrElie, TombRoland

Urethral wart clearance
Adverse events

This systematic review of 26 articles found that 5-aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) was the most effective treatment for urethral condylomas in terms of clearance and recurrence rate, with a higher risk of adverse events compared to laser therapy or topical treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

31.

Could the human papillomavirus recombinant vaccine be a new valid approach in the management of ano-genital warts?

Author: SarroA, AiroldiC, PediciniA, Di TullioE, PecereA

HPV vaccine effectiveness

This study suggests that the HPV vaccine, which is used to prevent genital warts, might also be effective in treating existing warts. While previous reports have shown promise, more research is needed, particularly large studies, to confirm its effectiveness as a treatment and to determine the best way to use it for this purpose.

LetterA written message for communication and exchange of information between individuals.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
CommentA short article/note that provides an opinion/perspective/interpretation on a published paper/topic.

Language : English

32.

Effectiveness and safety of topical application of diphenylcyclopropenone versus podophyllin in treatment of genital warts.

Author: HalimHalim Maher, AhmedSahar Fathy Abd Elshafy, EyadaMoustafa Mk

Genital wart treatment

Diphenylcyclopropenone is more effective than podophyllin in treating genital warts with a higher success rate and lower recurrence rate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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