Side Effects of gentamicin injection: A Synthesis of Findings from 9 Studies

  1. Home
  2. Side Effects of gentamicin injection
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of gentamicin injection: A Synthesis of Findings from 9 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of gentamicin injection: A Synthesis of Findings from 9 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Gentamicin is a powerful aminoglycoside antibiotic, but its use is limited by its main side effects, ototoxicity and nephrotoxicity. 6 , 7 . Garlic, with its inherent antioxidant activity, may prove beneficial in preventing ototoxicity. 7 . This study investigated the effect of SAMC, DD, and SAC, three active compounds found in garlic, on gentamicin-induced ototoxicity in rats using brainstem evoked response audiometry (BERA). 6 . In another study, intravitreal gentamicin injection in rabbits showed its effectiveness in lowering intraocular pressure as a treatment for end-stage glaucoma. 9 . On the other hand, low-dose intratympanic gentamicin injection has shown promising results in controlling vertigo in patients with Ménière's disease. 8 . However, this treatment carries a risk of hearing loss as a side effect. 8 .

Reasons for side effects

Gentamicin ototoxicity is thought to be caused by damage to hair cells in the inner ear. 6 , 7 . Gentamicin accumulates in the mitochondria of hair cells, promoting the production of reactive oxygen species (ROS) and causing cell damage. 6 , 7 . The active ingredients in garlic have antioxidant properties, which is why they are expected to have a protective effect against gentamicin-induced hair cell damage. 6 , 7 .

Common side effects

Hearing Loss

Gentamicin is known to cause ototoxicity, and hearing loss is its most common side effect. 6 , 7 , 8 . Hearing loss gradually affects higher frequencies first, and can lead to deafness in severe cases. 6 , 7 . The risk of hearing loss may be higher with intratympanic gentamicin injection. 8 .

Nephrotoxicity

Gentamicin can also cause nephrotoxicity. 6 . Nephrotoxicity occurs when kidney function deteriorates, leading to symptoms such as decreased urine output, swelling, and blood in the urine. 6 .

Vertigo

Vertigo may occur after intratympanic gentamicin injection. 8 . This is because gentamicin can damage the balance organs in the inner ear. 8 .

Others

Other side effects of gentamicin reported include nausea, vomiting, rash, and allergic reactions. 6 , 7 .

Side effects management

Hearing Loss

Preventing gentamicin-induced hearing loss requires measures such as reducing the dosage, shortening the administration period, and monitoring kidney function. 6 , 7 . Garlic intake may also reduce gentamicin-induced hearing loss. 7 .

Nephrotoxicity

Preventing gentamicin-induced nephrotoxicity requires monitoring kidney function and adjusting the dosage as needed. 6 .

Vertigo

Vertigo caused by gentamicin is usually temporary. 8 . Consult a doctor if the vertigo is severe. 8 .

Comparison between studies

Commonalities in studies

Multiple studies have shown that gentamicin can cause ototoxicity and nephrotoxicity. 6 , 7 , 9 . It has also been suggested that active ingredients in garlic may reduce gentamicin-induced ototoxicity. 6 , 7 .

Differences in studies

The administration methods of gentamicin and the evaluation methods for side effects vary across studies. 6 , 7 , 9 , 8 . For instance, 6 , 7 evaluate ototoxicity by administering gentamicin to rats, while 9 evaluates intraocular pressure by injecting gentamicin intravitreally into rabbits. 8 evaluates vertigo by injecting gentamicin into the inner ear of patients with Ménière's disease.

Real-life application notes

Gentamicin is an effective antibiotic for treating bacterial infections, but it can cause ototoxicity and nephrotoxicity, so it is important to take it as directed by your doctor. 6 , 7 . Garlic intake may reduce gentamicin-induced ototoxicity, but consult your doctor about the amount and timing of garlic intake. 7 . If you experience hearing loss, dizziness, or any other symptoms while taking gentamicin, consult your doctor immediately. 6 , 7 , 8 .

Limitations of current research

Research on the side effects of gentamicin is still insufficient. 6 , 7 , 9 , 8 . In particular, much remains unknown about the long-term effects of gentamicin. 6 , 7 . Further research is needed to confirm the effectiveness of the active ingredients in garlic in reducing gentamicin-induced ototoxicity in humans. 6 , 7 .

Future research directions

Clinical trials involving humans are needed to investigate the side effects of gentamicin in more detail. 6 , 7 , 9 , 8 . It is also necessary to confirm the effectiveness of the active ingredients in garlic in reducing gentamicin-induced ototoxicity in humans. 6 , 7 . Additionally, the development of new treatments to mitigate the side effects of gentamicin is necessary. 6 , 7 .

Conclusion

Gentamicin is an effective antibiotic for treating bacterial infections, but it can cause ototoxicity and nephrotoxicity. 6 , 7 . When taking gentamicin, follow your doctor's instructions and consult your doctor immediately if you experience any side effects. 6 , 7 . The active ingredients in garlic are expected to reduce gentamicin-induced ototoxicity, but their effectiveness requires further research. 6 , 7 .

Literature analysis of 9 papers
Positive Content
7
Neutral Content
1
Negative Content
1
Article Type
5
0
0
0
9
1.

Treatment of perennial rhinitis with flunisolide corticosteroid spray.

Author: JonesL M, SpectorS L, EnglishG M, Taylor-DawsonK

Reduced eosinophils
Candida infection

Flunisolide nasal spray was not significantly different from placebo in treating perennial rhinitis. Both groups showed a decrease in eosinophils on nasal smears.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Flunisolide--a new intranasal steroid for the treatment of allergic rhinitis.

Author: SahayJ N, ChatterjeeS S, EnglerC

Improved everyday life
Improved sleep quality
Relieved nasal obstruction
Relieved sneezing
Minor side effects

A study of 50 patients with perennial allergic rhinitis found that flunisolide nasal spray (200 micrograms daily) was significantly more effective than a placebo in reducing symptoms of sneezing, nasal congestion, post-nasal drip, and improving sleep and daily life. Both patients and doctors preferred the flunisolide spray. Minor side effects were reported during both placebo and flunisolide phases, and no evidence of adrenal suppression was observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Flunisolide nasal spray for perennial rhinitis in children.

Author: SarsfieldJ K, ThomsonG E

Effective rhinitis treatment
No adrenal axis effect
Safe for children
Nasal stinging

A study of 27 children with perennial rhinitis found that flunisolide nasal spray was significantly more effective than a placebo in relieving symptoms. Patients, doctors, and diary card assessments all favored flunisolide. The most common side effect was temporary nasal stinging. Flunisolide treatment was safe and did not affect the pituitary-adrenal axis. The study concluded that flunisolide is a safe and effective treatment for perennial rhinitis in children.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

A comparative trial testing budesonide and flunisolide nasal sprays in patients with seasonal allergic rhinitis.

Author: PipkornU, GeterudA

Effective for rhinitis
Nasal irritation

Both budesonide and flunisolide nasal sprays were effective in controlling nasal symptoms in patients with seasonal allergic rhinitis. However, flunisolide was associated with a higher incidence of nasal irritation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Short-term efficacy trial and twenty-four-month follow-up of flunisolide nasal spray in the treatment of perennial rhinitis.

Author: ClaytonD E, KooistraJ B, GellerM, OuelletteJ, CohenM, ReedC E, BusseW

No adrenal suppression
Safe and effective

Flunisolide nasal spray was found to be safe and effective in treating perennial rhinitis. No serious side effects were observed over a two-year follow-up period.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.