Side Effects of lidocaine transdermal patch: A Synthesis of Findings from 10 Studies

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Original Abstract of the Article

Main Research Findings

Lidocaine patches have been used for local analgesia in dogs and cats. 8 found that applying lidocaine patches to cats for 72 hours resulted in a steady-state plasma lidocaine concentration well below systemically toxic levels, with no observed clinical side effects. The study suggests that lidocaine patches are safe for use in cats.

7 found that lidocaine patches were effective in treating pain during percutaneous endoscopic lumbar discectomy (PELD) surgery, with tolerable side effects.

4 found that lidocaine patches were effective in reducing postoperative pain after laparoscopic appendectomy, with mild side effects.

Reasons for Side Effects

Side effects of lidocaine transdermal patches are caused by lidocaine being absorbed through the skin into the bloodstream, leading to potential nervous system effects. Direct application of lidocaine to the skin can also cause skin irritation and allergic reactions.

Common Side Effects

Skin Irritation

Skin irritation, such as redness, itching, and pain, is a common side effect of lidocaine transdermal patches, reported in 8 , 7 , and 4 studies. This is likely due to the direct contact of lidocaine with the skin.

Allergic Reaction

Lidocaine transdermal patches can trigger allergic reactions, potentially severe, in individuals with allergies to lidocaine. Symptoms include rash, hives, difficulty breathing, and anaphylactic shock. While rare, this side effect can be serious.

Nervous System Effects

As lidocaine levels rise in the bloodstream, it can affect the nervous system, causing side effects like dizziness, headache, drowsiness, nausea, vomiting, numbness, tremors, and seizures.

Countermeasures for Side Effects

Skin Irritation

Keeping the skin clean before applying lidocaine patches is crucial. If skin irritation occurs, remove the patch and consult a doctor.

Allergic Reactions

Avoid using lidocaine transdermal patches if you are allergic to lidocaine. Seek immediate medical attention if an allergic reaction occurs while using these patches.

Nervous System Effects

Consult a doctor if you experience dizziness, headache, drowsiness, or other symptoms while using lidocaine transdermal patches.

Comparison between Studies

Commonalities

Across multiple studies, lidocaine transdermal patches have demonstrated effectiveness in reducing pain. 8 , 7 , and 4 studies showed the effectiveness of lidocaine patches in reducing postoperative pain and neuropathic pain.

Differences

Studies varied in their target diseases, frequency, and severity of side effects. For example, 8 focused on the systemic and local absorption of lidocaine patches in cats, while 7 investigated the effectiveness of lidocaine patches during lumbar discectomy surgery. 4 studied the effectiveness of lidocaine patches in reducing postoperative pain after laparoscopic appendectomy.

Precautions for Real-Life Applications

Lidocaine transdermal patches are useful for managing pain, particularly after surgery and for neuropathic pain. However, it's vital to consult a doctor before using them due to potential skin irritation and allergic reactions. If you experience dizziness, headache, drowsiness, or other symptoms, seek medical advice.

Limitations of Current Research

Research on lidocaine transdermal patches is still limited. Further research is needed to understand the long-term side effects and effectiveness against various diseases.

Directions for Future Research

Future research should focus on long-term side effects of lidocaine transdermal patches and their effectiveness against a wider range of diseases. Additionally, studies should clarify the relationship between plasma lidocaine levels and side effects.

Conclusion

Lidocaine transdermal patches can be effective for pain management, but it's essential to consult a doctor before using them due to potential side effects. If you experience any unusual symptoms, seek medical advice promptly.

Literature analysis of 10 papers
Positive Content
10
Neutral Content
0
Negative Content
0
Article Type
4
0
1
0
10
1.

Achievements in Hypothyroidism Treatment with Herbal Medicine: A Systematic Review of Randomized Controlled Trials.

Author: JavidiNajmeh, KhorasaniZahra Mazloum, SalariRoshanak, NiroumandShabnam, YousefiMahdi

Hypothyroidism treatment

Hypothyroidism is a common condition that can cause health problems, especially in older adults. While medications are used to treat hypothyroidism, they can have side effects. Herbal remedies are being explored as a potential treatment for hypothyroidism that can regulate thyroid hormones and reduce side effects.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Analgesic effects of a 5% lidocaine patch after cesarean section: A randomized placebo-controlled double-blind clinical trial.

Author: de QueirozVaniely Kaliny Pinheiro, da Nóbrega MarinhoAlexandre Magno, de BarrosGuilherme Antonio Moreira

Reduced pain
None reported

A 5% lidocaine patch was evaluated for its analgesic effects in 72 women undergoing cesarean section. The lidocaine patch reduced pain scores significantly compared to placebo in the first 36 hours after surgery, but did not influence opioid consumption, quality of recovery, or the incidence of side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Effect of Topical Lidocaine Patch on Postoperative Pain Management in Laparoscopic Appendectomy: A Randomized, Double-Blind, Prospective Study.

Author: LeeWooSurng, HahnKooYong, HurJungPil, KimYongHun

Postoperative pain control
Topical analgesia

This study investigated the effectiveness of lidocaine patches in managing postoperative pain following laparoscopic appendectomy. Topical analgesics like lidocaine patches offer advantages over oral and parenteral routes, minimizing severe side effects and drug-drug interactions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Lidocaine 5 % patches as an effective short-term co-analgesic in cancer pain. Preliminary results.

Author: Garzón-RodríguezCristina, Casals MerchanMiquel, Calsina-BernaAgnes, López-RómboliEugenia, Porta-SalesJosep

Effective pain relief
IAT needed

This prospective, descriptive, non-controlled, non-randomized, open-label study evaluated the short-term efficacy and patients' subjective perception of the use of lidocaine 5 % patches for painful scars and pain caused by chest wall tumors. Lidocaine 5 % patches were effective in the short term for treating neuropathic cancer pain accompanied by allodynia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Pharmacokinetics of lidocaine following the application of 5% lidocaine patches to cats.

Author: KoJ C H, MaxwellL K, AbboL A, WeilA B

Local analgesia

Lidocaine patches provide local analgesia in cats, with low systemic absorption and high local concentrations. The study found that only a small portion of the lidocaine dose reaches systemic circulation, while high concentrations remain in the skin, supporting the safe use of lidocaine patches in cats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Transdermal diclofenac patch vs eutectic mixture of local anesthetics for venous cannulation pain.

Author: AgarwalAnil, GautamSujeet, GuptaDevendra, SinghUttam

Pain reduction
Blanching
Edema
Erythema
Induration

Both transdermal diclofenac patch and EMLA cream were found to be equally effective in reducing venous cannulation pain. However, the diclofenac patch showed less frequent signs of erythema, induration, and edema compared to EMLA cream.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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