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Review article: high-dose aminosalicylates to induce and maintain remissions in ulcerative colitis.

Author: HanauerS B

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Mesalazine, the active ingredient in sulfasalazine, is effective in treating ulcerative colitis (UC). Oral mesalazine is more effective than sulfasalazine at doses up to 4.8 g/day and has fewer side effects. Combination therapy with oral and rectal mesalazine is more effective than monotherapy in patients with distal or extensive colitis.
Paper Details　
Original Abstract of the Article :
Sulfasalazine was the first aminosalicylate to be used for induction and maintenance therapy of ulcerative colitis (UC). Initial trials demonstrated a dose response that was compromised by dose-related intolerance. Recognition that the 5-aminosalicylic acid moiety (5-ASA, mesalazine) is the active i...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2036.2006.03058.x

データ提供：米国国立医学図書館（NLM）

High-Dose Aminosalicylates for Ulcerative Colitis

The intricate world of inflammatory bowel diseases presents a myriad of challenges, and ulcerative colitis (UC) is a debilitating condition that affects the colon. This research explores the use of high-dose aminosalicylates, a class of medications used to treat UC, in inducing and maintaining remission. The authors provide a comprehensive review of the literature, highlighting the efficacy and safety of high-dose aminosalicylates in managing UC.

High-Dose Aminosalicylates: A Promising Approach for UC

The study reveals that increasing the dose of mesalazine, a specific aminosalicylate, can significantly improve the induction of remission in patients with UC, particularly those with more moderate disease activity. Furthermore, the authors emphasize that high-dose aminosalicylates are well-tolerated, with minimal dose-related side effects.

Managing UC with Confidence

This research offers valuable insights for patients with UC and their healthcare providers. By understanding the efficacy and safety profile of high-dose aminosalicylates, clinicians can tailor treatment plans to optimize patient outcomes and empower individuals to manage their condition with confidence and control.

Dr. Camel's Conclusion

This review sheds light on the potential of high-dose aminosalicylates in managing ulcerative colitis. The findings highlight their effectiveness in inducing and maintaining remission, providing patients with a valuable tool for managing this challenging condition. It's a reminder that we must continually explore new treatment options and refine our understanding of existing therapies to provide the best possible care for individuals living with inflammatory bowel diseases.

Date :
  1. Date Completed 2007-05-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16961743

DOI: Digital Object Identifier

10.1111/j.1365-2036.2006.03058.x

SNS
PICO Info
in preparation
Languages

English

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