Side Effects of methylergonovine: A Synthesis of Findings from 25 Studies

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Original Abstract of the Article

Major Research Findings

Methylergonovine is widely used to prevent and treat excessive bleeding after childbirth. 4 , 8 , 25 , 10 , 18 Studies have shown that methylergonovine effectively reduces postpartum bleeding. However, it is also known that methylergonovine has some side effects.

Reasons for Side Effects

In addition to its effect of promoting uterine contractions, methylergonovine also has a vasoconstrictive effect. 4 Vasoconstriction can increase blood pressure and put stress on the heart.

Common Side Effects

Nausea and Vomiting

Methylergonovine can cause nausea and vomiting. 6 , 24 , 1 This is because methylergonovine affects the nerves in the digestive system.

Headache

Methylergonovine can cause headaches. 14 , 24 This is because methylergonovine constricts blood vessels, which can affect the blood vessels in the head.

High Blood Pressure

Methylergonovine can raise blood pressure. 4 , 6 , 1 This is because methylergonovine constricts blood vessels.

Heart Abnormalities

Methylergonovine can cause heart abnormalities. 1 This is because methylergonovine can put stress on the heart.

Side Effect Countermeasures

Countermeasures for Nausea and Vomiting

If you are concerned about nausea and vomiting, talk to your doctor. They may prescribe anti-nausea medication.

Countermeasures for Headaches

If you are concerned about headaches, talk to your doctor. They may prescribe pain medication.

Countermeasures for High Blood Pressure

If you are concerned about high blood pressure, talk to your doctor. They may prescribe medication to lower your blood pressure.

Countermeasures for Heart Abnormalities

If you are concerned about heart abnormalities, talk to your doctor. They will provide appropriate care.

Comparison Between Studies

Commonalities Between Studies

Many studies have shown that methylergonovine effectively reduces postpartum bleeding. It has also been consistently shown that methylergonovine can cause side effects such as nausea, vomiting, headaches, and high blood pressure.

Differences Between Studies

The incidence and severity of side effects from methylergonovine may vary depending on the study. This is because the patients in the studies and the dosage of methylergonovine used may vary.

Precautions for Application in Real Life

Methylergonovine is a medication used to prevent postpartum bleeding. It is important to use methylergonovine with an understanding of the risk of side effects. Talk to your doctor before using methylergonovine.

Current Limitations of Research

There is not yet enough research on methylergonovine. More research is needed. In particular, further research is needed on the side effects of methylergonovine when used long-term.

Future Research Directions

Further research on methylergonovine should focus on the following points:

  • Side effects from long-term use of methylergonovine
  • Improved effectiveness and safety of methylergonovine
  • Development of alternative drugs to methylergonovine

Conclusion

Methylergonovine is an effective medication for preventing postpartum bleeding, but it can cause side effects such as nausea, vomiting, headaches, and high blood pressure. It is important to understand the risks of side effects when using methylergonovine. Consult your doctor before using methylergonovine.

Literature analysis of 25 papers
Positive Content
21
Neutral Content
0
Negative Content
4
Article Type
9
0
0
3
24
2.

A randomized controlled trial of methylergonovine prophylaxis after dilation and evacuation abortion.

Author: KernsJennifer L, PearlsonGeffan, MengeshaBiftu, HarterKristin, JacksonRebecca A, DreyEleanor A

Increased bleeding
Uterine bleeding

Prophylactic post-procedure methylergonovine does not improve excessive bleeding after dilation and evacuation (D&E) at 20-24 weeks. In fact, methylergonovine may increase uterine bleeding.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Uterotonic Medications: Oxytocin, Methylergonovine, Carboprost, Misoprostol.

Author: ValleraCristianna, ChoiLynn O, ChaCatherine M, HongRichard W

Uterine atony treatment
Severe side effects

This article reviews the current role of oxytocin, methylergonovine, carboprost, and misoprostol in the prevention and treatment of uterine atony, a common cause of postpartum hemorrhage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

The Effect of the Combined Use of Methylergonovine and Oxytocin during Caesarean Section in the Prevention of Post-partum Haemorrhage.

Author: ŞentürkŞenol, KağıtçıMehmet, BalıkGülşah, ArslanHalit, Kır ŞahinFigen

Prevents uterine atony
Reduced postpartum hemorrhage

The combined use of methylergonovine and oxytocin infusion during the intra-operative period of Caesarean section reduced the level of post-partum haemorrhage considerably without any adverse side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

[Update on the use of uterotonic agents].

Author: Manrique MuñozS, Munar BauzàF, Francés GonzálezS, Suescun LópezM C, Montferrer EstruchN, Fernández López de HierroC

Postpartum Haemorrhage Prevention
Uterotonic Side Effects

Postpartum haemorrhage (PPH) is a significant cause of maternal mortality. This study reviewed the use of uterotonic agents for the prevention and treatment of PPH, including oxytocin, carbetocin, ergot derivatives, and prostaglandins.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Spanish

6.

Postpartum severe sinus bradycardia following methylergonovine administration.

Author: IbrahimS M, MustafaE, LouonA

Delayed side effects
Hypertension
Tachycardia

This case report describes a patient experiencing serious delayed side effects from methylergonovine maleate administration, including nausea, vomiting, decreased heart rate, and increased blood pressure. Intravenous atropine sulphate further increased blood pressure and heart rate. The case highlights the need for close monitoring after methylergonovine maleate administration and potential risks associated with atropine sulphate administration following its use.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

A study of prophylactic use of 15-methyl prostalglandin F2alpha in the active management of third stage of labour.

Author: BiswasArati, BalRuna, KunduMrinal Kanti, KyalAmit, HalderModhusudan

postpartum hemorrhage prevention
third stage of labor management

Active management of the third stage of labor with 15-methyl prostaglandin F2alpha (PGF2alpha) was found to be more effective in reducing the duration of the third stage and the amount of bleeding than conventional management with methylergometrine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Oral misoprostol for the prevention of primary post-partum hemorrhage during third stage of labor.

Author: EnakpeneChristopher A, Morhason-BelloImran O, EnakpeneEvbu O, ArowojoluAyodele O, OmigbodunAkinyinka O

Blood loss reduction
Longer labor
Manual removal

Oral misoprostol was found to be more effective in reducing blood loss during the third stage of labor than intramuscular methylergometrine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Sublingual misoprostol versus methylergometrine for active management of the third stage of labor.

Author: VimalaN, MittalS, KumarS, DadhwalV, MehtaS

Reduced postpartum hemorrhage
Fever
Shivering

Sublingual misoprostol was found to be as effective as intravenous methylergometrine in preventing postpartum hemorrhage. However, larger randomized studies are needed to advocate its routine use.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Misoprostol compared with methylergometrine for the prevention of postpartum haemorrhage: a double-blind randomised trial.

Author: AmantF, SpitzB, TimmermanD, CorremansA, Van AsscheF A

Reduced haemorrhage
Side effects

Misoprostol and methylergometrine provide similar protection against postpartum hemorrhage, but misoprostol is associated with more side effects, including fever and shivering.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Instability of (methyl)ergometrine in tropical climates: an overview.

Author: HogerzeilH V, WalkerG J

Prevented postpartum hemorrhage
Low potency ergometrine

Parenteral ergometrine is unstable in tropical climates and may lose potency if stored unrefrigerated or exposed to light. Parenteral oxytocin is more stable and is a better choice for the prevention and treatment of postpartum haemorrhage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

[The side effects of the prevention of blood loss in the placental period].

Author: DimitrovA, NalbanskiB, BorisovS, NikolovA, DzherovL, GamishevG

Postpartum bleeding prevention
Difficult placenta delivery
High blood pressure

This study concluded that routine prophylactic use of oxytocin after delivery of the head is justified to prevent blood loss during the placental period.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Bulgarian

15.

Sulprostone in the control of postpartum haemorrhage.

Author: LaajokiV I, KivikoskiA I

Postpartum hemorrhage control
Mild side effects

Sulprostone, a PGE2 analogue, was administered to 74 patients to control postpartum haemorrhage. The 100 micrograms intravenous group had 386 +/- 175 ml blood loss, the 200 micrograms intramuscular group had 325 +/- 197 ml, and the methylergometrine-oxytocin group had 302 +/- 202 ml. Sulprostone 200 micrograms i.m. seems effective, with only four patients experiencing mild side-effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Use of intramyometrial injection of prostaglandin F 2 alpha in the management of intractable hemorrhage due to uterine atony.

Author: VincentiE, TambuscioB, MarchesoniD, GraziottinA, Di LenardoL, ChiarandaM

Control hemorrhage
Uterine atony
Intravascular injection

Prostaglandin F2 alpha is effective in treating severe hemorrhage due to uterine atony. It is a safe and effective treatment for patients who do not respond to conventional treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Maternal and fetal effects of uterine stimulants and relaxants.

Author: PetrieR H, DaniloP

Uterine relaxation
Uterine stimulation
Fetal side effects
Maternal side effects

Many drugs are available to stimulate or relax the gravid uterus, but all have potential side effects for both mother and fetus. It is important to understand the full range of effects these drugs can have.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

Methylergometrine: comparison of plasma concentrations and clinical response of two brands.

Author: AllonenH, JuvakoskiR, KantoJ, LaitinenS, MäntyläR, KleimolaT

No significant differences between brands
Mild side effects

Two brands of methylergometrine (Methergin and Myomergin) were equivalent in serum concentrations and clinical efficacy. Both were well-tolerated with few and mild side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

The role of methylergonovine maleate in augmenting extraamniotic saline for midtrimester abortion.

Author: NarvekarM R, PachauriS, MhatreV, GanguliA C

Midtrimester abortion
Incomplete abortions

Methylergonovine maleate (MEM) was evaluated for its effectiveness in augmenting the effect of saline instillation for midtrimester abortion. MEM significantly increased the percentage of patients aborting within 24 hours compared to those not receiving MEM. While the difference in abortion rates was not statistically significant at 36 and 48 hours, the cumulative abortion rates were higher in the MEM group. Complications and side effects were similar in both groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

[A combination of nifedipine and diltiazem in the treatment of refractory spastic angina].

Author: BoryM, JolyP, BonnetJ L, CoutelenN

Treats spastic angina
Side effects

Diltiazem (D) and nifedipine (N) were studied in combination for spastic angina. While both drugs were effective alone, combined treatment with half doses provided greater protection against coronary spasm compared to monotherapy. This approach offers potential for treating spastic angina while reducing side effects.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : French

21.

Methylergometrine: comparison of plasma concentrations and clinical response of two brands.

Author: AllonenH, JuvakoskiR, KantoJ, LaitinenS, MäntyläR, KleimolaT

No significant differences between brands
Mild side effects

Two brands of methylergometrine (Methergin and Myomergin) were equivalent in serum concentrations and clinical efficacy. Both were well-tolerated with few and mild side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

The role of methylergonovine maleate in augmenting extraamniotic saline for midtrimester abortion.

Author: NarvekarM R, PachauriS, MhatreV, GanguliA C

Midtrimester abortion
Incomplete abortions

Methylergonovine maleate (MEM) was evaluated for its effectiveness in augmenting the effect of saline instillation for midtrimester abortion. MEM significantly increased the percentage of patients aborting within 24 hours compared to those not receiving MEM. While the difference in abortion rates was not statistically significant at 36 and 48 hours, the cumulative abortion rates were higher in the MEM group. Complications and side effects were similar in both groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

[A combination of nifedipine and diltiazem in the treatment of refractory spastic angina].

Author: BoryM, JolyP, BonnetJ L, CoutelenN

Treats spastic angina
Side effects

Diltiazem (D) and nifedipine (N) were studied in combination for spastic angina. While both drugs were effective alone, combined treatment with half doses provided greater protection against coronary spasm compared to monotherapy. This approach offers potential for treating spastic angina while reducing side effects.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : French

24.

Efficacy and tolerability of intravenous methylergonovine in migraine female patients attending the emergency department: a pilot open-label study.

Author: Niño-MaldonadoAlfredo I, Caballero-GarcíaGary, Mercado-BocheroWilfrido, Rico-VillademorosFernando, CalandreElena P

Migraine treatment

Methylergonovine is an ergot alkaloid that is being investigated as a potential treatment for severe migraine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

25.

Low-dose sublingual misoprostol versus methylergometrine for active management of the third stage of labor.

Author: ChhabraShakuntala, TickooChandan

Effective prevention
Low cost
Stable at room temperature

Low-dose sublingual misoprostol was as effective as intravenous methylergometrine in preventing post-partum hemorrhage in low-risk cases. Misoprostol is a better choice due to its stability, cost-effectiveness, and ease of administration.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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