Side Effects of olmesartan: A Synthesis of Findings from 20 Studies

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Original Abstract of the Article

Major Research Findings

Olmesartan is a widely used angiotensin II receptor blocker (ARB) for the treatment of hypertension. However, some studies have suggested that olmesartan may be associated with enteropathy. A nationwide observational cohort study in Korea ( 7 ) found no association between olmesartan and the risk of enteropathy. However, a case report ( 5 ) described a patient who experienced diarrhea and weight loss after taking olmesartan, and the symptoms resolved after discontinuation of olmesartan. Additionally, three cases of severe olmesartan-associated chronic diarrhea with weight loss and malabsorption syndrome were reported ( 6 ), where symptoms improved after stopping the medication.

Olmesartan may be more effective in lowering blood pressure compared to other antihypertensive medications. A study ( 12 ) suggested that olmesartan may be superior to other angiotensin II receptor antagonists in reducing blood pressure. Furthermore, a study ( 18 ) demonstrated that the combination of olmesartan and amlodipine improved blood pressure control. Additionally, a review ( 9 ) showed that the combination of olmesartan with other medications may lead to improved blood pressure management.

Reason for Side Effects

The exact reason why olmesartan causes enteropathy is not fully understood. However, a study ( 5 ) suggested that olmesartan may cause inflammation in the intestines. Additionally, another study ( 6 ) suggested that olmesartan might cause villous atrophy in the intestines.

Common Side Effects

Diarrhea

Diarrhea is one of the most common side effects of olmesartan. Three cases of severe chronic diarrhea were reported ( 6 ). Additionally, a case report ( 5 ) described a patient who experienced diarrhea after taking olmesartan.

Weight Loss

Olmesartan can lead to weight loss by causing diarrhea. A case report ( 5 ) described a patient who experienced weight loss after taking olmesartan.

Other Side Effects

Olmesartan may cause other side effects, such as headache, upper respiratory tract infection, back pain, muscle cramps, fatigue, dizziness, and more. A review ( 13 ) reported that olmesartan can cause various side effects, including headache, upper respiratory tract infection, back pain, muscle cramps, fatigue, dizziness, etc.

Side Effect Management

Diarrhea Management

If you experience diarrhea while taking olmesartan, consult your doctor. You may need to stop taking olmesartan or switch to a different medication. A case report ( 5 ) reported that diarrhea improved after stopping olmesartan.

Weight Loss Management

If you experience weight loss while taking olmesartan, consult your doctor. If diarrhea is the cause, treating diarrhea may improve weight loss.

Other Side Effect Management

If you experience other side effects while taking olmesartan, consult your doctor.

Comparison Between Studies

Similarities Between Studies

Many studies have shown that olmesartan is an effective medication for lowering blood pressure. Studies ( 12 , 18 , 9 ) have shown that olmesartan effectively reduces blood pressure. Additionally, some studies have suggested that olmesartan may be associated with enteropathy. Studies ( 7 , 5 , 6 ) have reported an association between olmesartan and the risk of enteropathy.

Differences Between Studies

The association between olmesartan and the risk of enteropathy varies across studies. One study ( 7 ) found no association, while other studies ( 5 , 6 ) suggested an association.

Practical Implications

Olmesartan is an effective drug for lowering blood pressure, but it may cause side effects such as enteropathy. Studies ( 7 , 5 , 6 ) have reported an association between olmesartan and the risk of enteropathy. If you are taking olmesartan, discuss the potential side effects with your doctor and ensure you understand the risks involved. If you experience symptoms such as diarrhea, consult your doctor immediately.

Limitations of Current Research

The association between olmesartan and the risk of enteropathy is not fully understood and requires further investigation. More research is needed to determine the risk factors associated with developing enteropathy after taking olmesartan. Additionally, the mechanism by which olmesartan causes enteropathy remains unclear. Future research should focus on elucidating this mechanism.

Future Research Directions

Further research is needed to investigate the association between olmesartan and the risk of enteropathy in more detail. Specifically, identifying risk factors for developing enteropathy after taking olmesartan is crucial. Additionally, research is needed to understand the mechanism by which olmesartan causes enteropathy and to develop new treatment strategies for mitigating side effects.

Conclusion

Olmesartan is an effective medication for lowering blood pressure, but it may cause side effects such as enteropathy. It is important to discuss potential side effects with your doctor before taking olmesartan and to understand the risks involved. If you experience symptoms such as diarrhea, consult your doctor immediately. Future research should focus on elucidating the association between olmesartan and the risk of enteropathy and understanding the mechanism by which olmesartan causes enteropathy.

Literature analysis of 20 papers
Positive Content
13
Neutral Content
1
Negative Content
6
Article Type
1
0
0
6
19
1.

Review article: drug-induced small bowel injury.

Author: HamdehShadi, MicicDejan, HanauerStephen

Bowel perforation
Gastrointestinal injury

This review summarizes medications linked to the development of small bowel injury. Drug-induced enteropathy can range from asymptomatic histological changes to chronic inflammatory conditions or bowel perforation. It is crucial for physicians to be aware of the manifestations of drug-induced enteropathy for timely diagnosis and management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

[Impact of stopping reimbursement of olmesartan for hypertensive patients in primary care].

Author: HumbertX, RabiazaA, SchonbrodtL, RaginelT, Le BasF

Enteropathy
Hypertension

Stopping the reimbursement of olmesartan for hypertensive patients in France resulted in a significant decrease in olmesartan prescriptions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : French

7.

Olmesartan is not associated with the risk of enteropathy: a Korean nationwide observational cohort study.

Author: YouSeng Chan, ParkHojun, YoonDukyong, ParkSooyoung, JoungBoyoung, ParkRae Woong

Enteropathy

Olmesartan, an angiotensin II receptor blocker (ARB), has been linked to sprue-like enteropathy. This study investigated the association between olmesartan and other ARBs and the incidence of enteropathy in Korea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

8.

Drug-induced enteropathy.

Author: MariettaEric V, CarteeAmanda, RishiAbdul, MurrayJoseph A

Diarrhea

This review focuses on drug-induced diarrhea caused by olmesartan and mycophenolic acid (CellCept), which can increase inflammation and enteropathy in some individuals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

[ARB's in combination therapy].

Author: AbacıAdnan

Improved blood pressure control
Side effects

Combination therapy, particularly with angiotensin receptor blockers, is often required to adequately control blood pressure, especially in patients with severe hypertension.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Turkish

10.

Renal failure and rhabdomyolysis associated with sitagliptin and simvastatin use.

Author: KaoD P, KohrtH E, KuglerJ

Oral glucose lowering
Headache
Pharyngitis

Sitagliptin is a new oral medication for lowering glucose levels that works through the incretin hormone system. Common side effects are headache and pharyngitis, with few serious adverse events reported during clinical trials. Dose adjustment is recommended for patients with kidney problems.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Antagonizing the angiotensin II subtype 1 receptor: a focus on olmesartan medoxomil.

Author: NussbergerJürg, KoikeHiroyuki

Cardioprotective effects
Reduced blood pressure
Renoprotective effects

Angiotensin II subtype 1 (AT1) receptor antagonists such as olmesartan represent a valid therapeutic option for the treatment of hypertension and other cardiovascular and renal diseases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Comparative antihypertensive efficacy of olmesartan: comparison with other angiotensin II receptor antagonists.

Author: OparilS

Reduced CV morbidity
Reduced CV mortality
ACE inhibitors side effects

This review discusses the benefits of angiotensin II receptor blockers (ARBs) in managing hypertension. ARBs, like ACE inhibitors, effectively lower blood pressure and have shown benefits in reducing cardiovascular morbidity and mortality. ARBs are particularly attractive due to their minimal side effects, making them a good first-line option for patients with multiple cardiovascular risk factors.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Drug Interactions with Angiotensin Receptor Blockers: Role of Human Cytochromes P450.

Author: YangRuirui, LuoZhiqiang, LiuYang, SunMohan, ZhengLing, ChenYingying, LiYanping, WangHao, ChenLingzhu, WuMing, ZhaoHuihui

ARBs for hypertension
ARB side effects

Angiotensin receptor blockers (ARBs) are effective for treating hypertension, but may cause side effects such as headache, upper respiratory infection, back pain, and fatigue.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Anti-inflammatory and anti-oxidant activities of olmesartan medoxomil ameliorate experimental colitis in rats.

Author: NagibMarwa M, TadrosMariane G, ElSayedMoushira I, KhalifaAmani E

Anti-inflammatory effects
Antioxidant effects
UC treatment

This study investigated the potential of olmesartan medoxomil, an angiotensin II receptor blocker, to ameliorate ulcerative colitis in a rat model. Olmesartan medoxomil dose-dependently reduced colonic histopathological and biochemical injuries, demonstrating its anti-inflammatory and antioxidant effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Azilsartan: a newly approved angiotensin II receptor blocker.

Author: LamSum

blood pressure lowering
well-tolerated
hypotension
worsening of renal function

Azilsartan is a new angiotensin II receptor blocker approved for the treatment of hypertension. The medication is effective in lowering blood pressure and is generally well tolerated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Efficacy and safety of olmesartan medoxomil and hydrochlorothiazide compared with benazepril and amlodipine besylate.

Author: KereiakesDean J, NeutelJoel M, PunziHenry A, XuJianbo, LipkaLeslie J, DubielRobert

Greater antihypertensive effect

Olmesartan medoxomil/HCTZ 40/12.5 and 40/25 mg/day combination therapy was well tolerated and demonstrated a greater antihypertensive effect than benazepril plus amlodipine besylate 20/5 and 20/10 mg/day, which enabled more patients to achieve targeted blood pressure goals.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Socio-economic status and the therapeutic effectiveness of antihypertensive treatment--the design of the LEO study.

Author: SchmidtA C, BramlageP, LichtenthalA, EckertM, ScholzeJ

Reduced cardiovascular risk
Drug side effects

The risk of arterial hypertension and subsequent cardiovascular disease morbidity and mortality increases with low socio-economic status. Olmesartan, an angiotensin receptor blocker, will be used to investigate the effectiveness of this drug in different socio-economic classes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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