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Drug Interactions with Angiotensin Receptor Blockers: Role of Human Cytochromes P450.

Author: ChenLingzhu, ChenYingying, LiYanping, LiuYang, LuoZhiqiang, SunMohan, WangHao, WuMing, YangRuirui, ZhaoHuihui, ZhengLing

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Angiotensin receptor blockers (ARBs) are effective for treating hypertension, but may cause side effects such as headache, upper respiratory infection, back pain, and fatigue.
Paper Details　
Original Abstract of the Article :
Angiotensin receptor blockers (ARBs) are the most recent class of agents for the treatment of hypertension. However, ARBs may cause a low incidence of headache, upper respiratory infection, back pain, muscle cramps, fatigue, dizziness, and many other side effects. In some cases, such toxicity is ass...See full text at original site
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引用元：
https://doi.org/10.2174/1389200217666160524143843

データ提供：米国国立医学図書館（NLM）

Drug Interactions with Angiotensin Receptor Blockers: Exploring the Role of Cytochromes P450

Angiotensin receptor blockers (ARBs) are widely used to treat hypertension. This review examines the potential drug interactions of ARBs, focusing on their impact on the activity of human cytochromes P450, a group of enzymes involved in drug metabolism. The authors highlight the importance of understanding these interactions to optimize ARB therapy and minimize potential adverse effects.

Navigating Drug Interactions: Understanding the Role of Cytochromes P450

This review provides valuable insights into the complex interplay between ARBs and human cytochromes P450. The knowledge of these drug interactions is essential for healthcare professionals to make informed decisions about medication regimens and to ensure patient safety.

Optimizing Medication Regimens: A Holistic Approach to Managing Hypertension

Managing hypertension requires a holistic approach, considering individual patient characteristics, potential drug interactions, and lifestyle factors. This review highlights the importance of carefully considering drug interactions, particularly those involving ARBs and cytochromes P450, to optimize medication regimens and minimize adverse events.

Dr. Camel's Conclusion

Just as a camel adapts to the changing desert environment, patients taking angiotensin receptor blockers (ARBs) may encounter unexpected challenges, such as drug interactions. This review, like a map guiding a desert traveler, provides valuable information about the potential interactions between ARBs and human cytochromes P450, enzymes essential for drug metabolism. Understanding these interactions is crucial for healthcare professionals to make informed decisions about medication regimens, ensuring patient safety and optimal treatment outcomes.
Date :
  1. Date Completed 2017-02-17
  2. Date Revised 2019-10-27
Further Info :

Pubmed ID

27216792

DOI: Digital Object Identifier

10.2174/1389200217666160524143843

SNS
PICO Info
in preparation
Languages

English

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