Side Effects of ranitidine: A Synthesis of Findings from 22 Studies

  1. Home
  2. Side Effects of ranitidine
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of ranitidine: A Synthesis of Findings from 22 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of ranitidine: A Synthesis of Findings from 22 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Findings

Ranitidine is a medication used to reduce stomach acid, and it is generally considered safe and effective. However, several studies have reported potential side effects associated with ranitidine. , , , 1 , , 2 , , 3 , , 6 These studies suggest that ranitidine side effects are generally mild and infrequent. However, some severe side effects have been documented, including anaphylaxis, hepatitis, and agranulocytosis.

Reasons for Side Effects

The side effects of ranitidine are primarily linked to its mechanism of action: reducing stomach acid production. While beneficial for conditions like ulcers, this can inadvertently disrupt the natural balance of the stomach environment. This can lead to bacterial overgrowth, potentially aggravating ulcers. Additionally, ranitidine, as an H2 receptor antagonist, has the potential to impact various organs beyond the digestive system, such as the nervous system, blood system, and liver.

Common Side Effects

Headache

A common side effect of ranitidine is headache. These headaches may occur within a few days of starting ranitidine and can range from mild to severe. If you experience severe headaches, consult your doctor.

Dizziness

Dizziness is another common side effect of ranitidine. It may occur within a few days of starting ranitidine and can vary in intensity. If you experience severe dizziness, consult your doctor.

Tiredness

Fatigue is also a reported side effect of ranitidine. It may occur within a few days of starting ranitidine and can range from mild to severe. If you experience persistent fatigue, consult your doctor.

Constipation

Constipation is a common side effect of ranitidine. It may occur within a few days of starting ranitidine and can vary in severity. Dietary changes and exercise can often help alleviate mild constipation, but if it is severe, consult your doctor.

Diarrhea

Diarrhea is another common side effect of ranitidine. It may occur within a few days of starting ranitidine and can vary in severity. If you experience persistent diarrhea, consult your doctor.

Nausea

Nausea is a reported side effect of ranitidine. It may occur within a few days of starting ranitidine and can range from mild to severe. If you experience persistent nausea, consult your doctor.

Abdominal Pain

Abdominal pain is a possible side effect of ranitidine. It may occur within a few days of starting ranitidine and can vary in severity. If you experience severe abdominal pain, consult your doctor.

Rash

Skin rash is a potential side effect of ranitidine. It may occur within a few days of starting ranitidine and can vary in severity. If you experience a rash, consult your doctor.

Itching

Itching is a possible side effect of ranitidine. It may occur within a few days of starting ranitidine and can vary in severity. If you experience persistent itching, consult your doctor.

Chest Tightening

Chest tightness is a potential side effect of ranitidine. If you experience chest tightness, consult your doctor immediately.

Bruising

Easy bruising is a potential side effect of ranitidine. If you notice easy bruising, consult your doctor.

Headache

Headache is a potential side effect of ranitidine. If you experience a headache, consult your doctor.

Abdominal Pain

Abdominal pain is a potential side effect of ranitidine. If you experience abdominal pain, consult your doctor.

Side Effect Management

Headache

Most headaches associated with ranitidine are mild and resolve on their own when the medication is discontinued. However, if headaches are severe, your doctor may prescribe medication to alleviate the symptoms.

Dizziness

Most dizziness associated with ranitidine is mild and resolves on its own when the medication is discontinued. However, if dizziness is severe, your doctor may prescribe medication to alleviate the symptoms.

Tiredness

Most fatigue associated with ranitidine is mild and resolves on its own when the medication is discontinued. However, if fatigue is persistent, your doctor may prescribe medication or investigate other potential causes.

Constipation

Most constipation associated with ranitidine is mild and can be managed with dietary changes and exercise. However, if constipation is severe, your doctor may prescribe medication to relieve the symptoms.

Diarrhea

Most diarrhea associated with ranitidine is mild and resolves on its own when the medication is discontinued. However, if diarrhea is persistent, your doctor may prescribe medication to alleviate the symptoms.

Nausea

Most nausea associated with ranitidine is mild and resolves on its own when the medication is discontinued. However, if nausea is persistent, your doctor may prescribe medication to alleviate the symptoms.

Abdominal Pain

Most abdominal pain associated with ranitidine is mild and resolves on its own when the medication is discontinued. However, if abdominal pain is severe, consult your doctor immediately.

Rash

Most rashes associated with ranitidine are mild and resolve on their own when the medication is discontinued. However, if the rash is severe, consult your doctor immediately.

Itching

Most itching associated with ranitidine is mild and resolves on its own when the medication is discontinued. However, if itching is persistent, consult your doctor.

Chest Tightening

If you experience chest tightness, consult your doctor immediately. This may be a sign of a serious reaction, and prompt medical attention is crucial.

Bruising

If you notice easy bruising, consult your doctor. This could be a sign of a blood clotting problem, and further investigation is necessary.

Headache

If you experience a headache, consult your doctor. They can help determine the cause of the headache and recommend appropriate treatment if necessary.

Abdominal Pain

If you experience abdominal pain, consult your doctor. They can help determine the cause of the abdominal pain and recommend appropriate treatment if necessary.

Comparison Across Studies

Commonalities

Multiple studies have found that ranitidine is generally safe and well-tolerated, with side effects occurring infrequently. , , , 1 , , 2 , , 3 , , 6 However, a few serious side effects have been reported across studies, such as anaphylaxis, hepatitis, and agranulocytosis.

Differences

The occurrence and severity of side effects can vary between individuals. Some people may experience only mild side effects, while others may experience more severe reactions. The dosage and duration of ranitidine use can also influence the likelihood and severity of side effects. Additionally, interactions with other medications can also play a role in side effect development.

Real-Life Applications: Things to Keep in Mind

While ranitidine is generally safe and effective, remember that it can cause side effects. Be aware of the potential side effects and discuss your concerns with your doctor before starting ranitidine. If you experience any side effects while taking ranitidine, especially severe or persistent ones, consult your doctor immediately.

Limitations of Current Research

There is still a need for further research into the long-term effects of ranitidine use, particularly on different populations and demographics. More research is required to better understand the causes of ranitidine side effects and identify potential risk factors.

Future Research Directions

Ongoing research into ranitidine should continue to explore its long-term effects, including potential long-term complications. Additionally, researchers should focus on identifying the mechanisms underlying the development of side effects and determining factors that might increase risk.

Conclusion

Ranitidine is an effective medication used to reduce stomach acid. However, it's crucial to be aware of its potential side effects. These side effects are generally mild and infrequent, but severe reactions are possible. Before starting ranitidine, consult your doctor about your medical history and discuss any concerns. If you experience any side effects while taking ranitidine, consult your doctor promptly.

Literature analysis of 22 papers
Positive Content
17
Neutral Content
0
Negative Content
5
Article Type
6
0
0
5
21
2.

[Side effects and safety of the new histamine H2 receptor antagonist ranitidine in the long-term treatment of patients with stomach and duodenal ulcers].

Author: MerynS, PötziR, BrunnerH, PesendorferF X, PamperlH

Treats peptic ulcers
Gastrointestinal symptoms

Ranitidine, an H2-receptor antagonist, was safe and well tolerated in long-term treatment of patients with prepyloric or duodenal ulcer.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

3.

Ranitidine-Induced Delirium in a 7-Year-Old Girl: A Case Report.

Author: CastroRoberta Esteves Vieira de, SousaCarolina da Cunha, de Magalhães-BarbosaMaria Clara, Prata-BarbosaArnaldo, CheniauxElie

Delirium

Ranitidine, a histamine-2 blocker, can cause central nervous system side effects like delirium in adults. This case report describes a child who developed delirium possibly caused by anticholinergic toxidrome secondary to ranitidine use. The report reinforces the importance of considering various factors that can trigger delirium and minimizing risk factors.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Severe ranitidine-induced anaphylaxis: a case report and literature review.

Author: AouamK, BouidaW, Ben FredjN, ChaabaneA, BoubakerH, BoukefR, BoughattasN A, NouiraS

None mentioned
Anaphylaxis

Ranitidine, a generally well-tolerated drug, may on occasions cause serious adverse effects, such as anaphylaxis.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Rapid in vitro screening of drug-metal ion interactions.

Author: SrideviN, YusuffK K Mohammed

Drug-metal interactions

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Clinical efficiency of Epigam in patients with exacerbation of peptic ulcer disease of the stomach and duodenum.

Author: BakumovP A, ShchepotkinI V, DuginaYu L, EpsteinO I, SergeevaS A

Peptic ulcer treatment
Safe treatment
Slower pain relief

Epigam, a medication containing antibodies to histamine in ultralow doses, was found to be an efficient and safe treatment for peptic ulcer disease of the stomach and duodenum in patients with Helicobacter pylori infection. In a study of 20 patients, Epigam was as effective as ranitidine in healing ulcers, but ranitidine relieved pain faster. Epigam did not cause any side effects.

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

H(2)-histamine antagonist (famotidine) induced adverse CNS reactions with long-standing secondary mania and epileptic seizures.

Author: von EinsiedelRegina W, Roesch-ElyD, DieboldK, SartorK, MundtC, BergemannN

Manic symptoms
Seizures

This study reports a case of a patient who developed manic symptoms and seizures after receiving famotidine, an H2-histamine antagonist. The study suggests that famotidine may cause central nervous system (CNS) adverse reactions similar to other H2-histamine antagonists.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Occupational allergic contact dermatitis from drugs in healthcare workers.

Author: GielenK, GoossensA

None mentioned
Occupational allergy

This report highlights the importance of occupational contact allergy to drugs in healthcare workers, with nurses being the most commonly affected group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

High-dose intravenous corticosteroid therapy for Graves' ophthalmopathy.

Author: MacchiaP E, BagattiniM, LupoliG, VitaleM, VitaleG, FenziG

Improved ophthalmopathy
Stable improvement
Cutaneous rashes
Gastric pain
Metal taste

Twenty-five patients with Graves' ophthalmopathy were treated with two weekly iv injections of 1 g of methylprednisolone for 6 weeks and compared to a group of 26 patients treated with oral prednisone. The high-dose iv steroid therapy provides efficient and stable improvement in Graves' ophthalmopathy with a lower incidence of side-effects compared to the classic oral therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Lansoprazole-based triple therapy versus ranitidine bismuth citrate-based dual therapy in the eradication of Helicobacter pylori in patients with duodenal ulcer: a multicenter, randomized, double-dummy study.

Author: LuzzaF, GiglioA, CilibertoE, BelmonteA, CavaliereC, SaccàN, FrandinaC, FioccaR, TrimboliV, PalloneF

H. pylori eradication

A proton pump inhibitor-based triple therapy regimen may be more effective than a ranitidine bismuth citrate-based dual therapy regimen in eradicating Helicobacter pylori in patients with duodenal ulcer, though further research is needed to confirm this.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Efficacy and tolerability of antibiotics in patients undergoing H. pylori eradication.

Author: DaneseS, ArmuzziA, RomanoA, CremoniniF, CandelliM, FranceschiF, OjettiV, VenutiA, PolaP, GasbarriniG, GasbarriniA

H. pylori eradication
Drug side effects

Triple rabeprazole-based eradicating regimens are effective and safe for the treatment of Helicobacter pylori (H. pylori) infection. The incidence of side effects was low and similar in the different three-drug regimens. Quadruple therapy, while effective as a second-line therapy, was associated with a significantly higher incidence of side effects compared to first-line treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Pharmacokinetics and pharmacodynamics of antiulcer agents in llama.

Author: ChristensenJ M, LimsakunT, SmithB B, HollingsheadN, HuberM

Acid suppression
Adverse drug reaction

This study compared the pharmacokinetics and acid-suppressing effects of ranitidine and omeprazole in llamas. Ranitidine showed a short half-life and minimal acid suppression, while omeprazole exhibited dose-dependent nonlinear pharmacokinetics and significant acid suppression at doses of 0.4 and 0.8 mg/kg.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Clarithromycin for Helicobacter pylori infection.

Author: LeungW K, GrahamD Y

H. pylori eradication
Resistance

Helicobacter pylori infection is a common cause of gastritis, peptic ulcer disease, and even gastric cancer. Clarithromycin is an effective antimicrobial against H. pylori but resistance is increasing. There is a need for improved therapies for H. pylori.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

How to treat Helicobacter pylori. First-line, second-line, and future therapies.

Author: MégraudF, MarshallB J

H. pylori eradication
Drug resistance

This article discusses the limitations of current therapies for Helicobacter pylori infection and highlights the need for new drugs that are effective against resistant strains and lack side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

Dose, efficacy and tolerability of long-term indomethacin treatment of chronic paroxysmal hemicrania and hemicrania continua.

Author: ParejaJ A, CamineroA B, FrancoE, CasadoJ L, PascualJ, Sánchez del RíoM

Chronic paroxysmal hemicrania relief
Hemicrania continua relief
Gastrointestinal side effects

This retrospective study assesses the dose and side-effects of prolonged indomethacin treatment for hemicrania continua (HC) and chronic paroxysmal hemicrania (CPH).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Two new treatment regimens for Helicobacter pylori eradication: a randomised study.

Author: De FrancescoV, ZulloA, HassanC, FaleoD, IerardiE, PanellaC, MoriniS

H. pylori eradication
Side effects

A 10-day regimen of omeprazole, amoxycillin, clarithromycin, and tinidazole resulted in a very high Helicobacter pylori eradication rate (96.8%), while a 5-day regimen of ranitidine bismuth citrate, clarithromycin, and tinidazole was less effective (67.2%).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Various durations of a standard regimen (amoxycillin, metronidazole, colloidal bismuth sub-citrate for 2 weeks or with additional ranitidine for 1 or 2 weeks) on eradication of Helicobacter pylori in Iranian peptic ulcer patients. A randomized controlled trial.

Author: KavianiM J, MalekzadehR, VahediH, SotoudehM, KamalianN, AminiM, MassarratS

H. pylori eradication

This study compared the effectiveness of a classic triple therapy for Helicobacter pylori with the addition of ranitidine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Dose reduction of steroid premedication for paclitaxel: no increase of hypersensitivity reactions.

Author: KöpplerH, HeymannsJ, WeideR

Hypersensitivity reaction prevention
Steroid side effects

Patients receiving paclitaxel often receive premedication with dexamethasone, ranitidine, and clemastine to prevent allergic reactions. The standard dexamethasone dose is 20 mg given orally 12 and 6 hours before paclitaxel. However, a single intravenous dose of 40 mg given just before paclitaxel is equally effective. To potentially reduce steroid side effects, especially in patients receiving weekly paclitaxel treatments, this study investigates reducing the dexamethasone dose.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

[Role of Helicobacter pylori infection in insulin-dependent diabetes mellitus].

Author: OjettiV, PitoccoD, GhirlandaG, GasbarriniG, GasbarriniA

H. pylori eradication
H. pylori reinfection

This study evaluated the prevalence, treatment efficacy, and reinfection rates of H. pylori infection in patients with insulin-dependent diabetes mellitus (IDDM) compared to a control group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Italian

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.