Side Effects of rimabotulinumtoxinb injection: A Synthesis of Findings from 29 Studies

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Original Abstract of the Article

Major research findings

RimabotulinumtoxinB is a promising alternative treatment for patients who have developed resistance to botulinum toxin type A or who cannot use botulinum toxin type A. 29 、 23 、 16 、 3 RimabotulinumtoxinB has been shown to be effective in treating various neurological conditions, such as cerebral palsy, dystonia, excessive salivation, hyperhidrosis, overactive bladder, spasticity, and shoulder impingement syndrome. 9 、 11 、 10 、 13 、 26 、 17 、 5 、 24 However, research also suggests that rimabotulinumtoxinB may cause more side effects than botulinum toxin type A. 29 、 27 、 14 、 8 、 18 、 19 、 3

Reasons for side effects

The exact reason why rimabotulinumtoxinB causes more side effects than botulinum toxin type A is not fully understood. However, studies suggest that rimabotulinumtoxinB may spread more widely throughout the body than botulinum toxin type A. 27 、 14 RimabotulinumtoxinB may also paralyze more muscles than botulinum toxin type A, which could contribute to increased side effects. 19 、 3

Common side effects

Dry mouth

RimabotulinumtoxinB can cause dry mouth. 29 、 27 、 18 、 3 This is because rimabotulinumtoxinB inhibits the function of salivary glands.

Difficulty swallowing

RimabotulinumtoxinB can cause difficulty swallowing. 29 、 27 This is because rimabotulinumtoxinB inhibits the function of muscles involved in swallowing.

Visual impairment

RimabotulinumtoxinB can cause visual impairment. 18 This is because rimabotulinumtoxinB inhibits the function of eye muscles.

Reduced sweating

RimabotulinumtoxinB can cause reduced sweating. 29 、 27 This is because rimabotulinumtoxinB inhibits the function of sweat glands.

Constipation

RimabotulinumtoxinB can cause constipation. 29 、 27 This is because rimabotulinumtoxinB inhibits the function of intestinal muscles.

Difficulty urinating

RimabotulinumtoxinB can cause difficulty urinating. 29 、 27 This is because rimabotulinumtoxinB inhibits the function of bladder muscles.

Headache

RimabotulinumtoxinB can cause headache. 8 This is because rimabotulinumtoxinB inhibits nerve function.

Flu-like symptoms

RimabotulinumtoxinB can cause flu-like symptoms. 8 This is because rimabotulinumtoxinB affects the immune system.

Muscle weakness

RimabotulinumtoxinB can cause muscle weakness. 3 This is because rimabotulinumtoxinB inhibits muscle function.

Measures to address side effects

Dry mouth

To address dry mouth, it is important to drink plenty of fluids. You can also use medications to prevent dry mouth, as directed by your doctor.

Difficulty swallowing

To address difficulty swallowing, eat slowly and chew your food thoroughly. If necessary, you can use medications to help with swallowing, as directed by your doctor.

Visual impairment

To address visual impairment, seek treatment from your doctor, as directed. Also, avoid driving or hazardous activities until your vision improves.

Reduced sweating

To address reduced sweating, stay in cool environments and dress lightly. You can also use medications to promote sweating, as directed by your doctor.

Constipation

To address constipation, eat a diet high in fiber and drink plenty of fluids. You can also use laxatives, as directed by your doctor.

Difficulty urinating

To address difficulty urinating, seek treatment from your doctor. You can also use medications to promote urination.

Headache

To address headache, use pain relievers, as directed by your doctor. Also, get plenty of rest.

Flu-like symptoms

To address flu-like symptoms, take medications, as directed by your doctor. Also, get plenty of rest.

Muscle weakness

To address muscle weakness, undergo rehabilitation therapy, as directed by your doctor. You can also perform appropriate exercises and stretches to reduce muscle strain.

Comparison between studies

Commonalities between studies

Many studies have shown that rimabotulinumtoxinB may cause more side effects than botulinum toxin type A. 29 、 27 、 14 、 8 、 18 、 19 、 3 Additionally, many studies suggest that rimabotulinumtoxinB may spread more widely throughout the body than botulinum toxin type A. 27 、 14

Differences between studies

Studies report varying results regarding the efficacy and side effects of rimabotulinumtoxinB compared to botulinum toxin type A. For example, a study found that rimabotulinumtoxinB may cause more autonomic side effects than botulinum toxin type A. 27 However, another study reported that rimabotulinumtoxinB may have a shorter duration of effect than botulinum toxin type A. 3 These differences in findings could be due to variations in study design and participant characteristics.

Considerations for real-life application

While rimabotulinumtoxinB is an effective medication for treating many neurological conditions, it is important to consider the risk of side effects. Side effects such as dry mouth, difficulty swallowing, and visual impairment can significantly impact daily life. Before considering the use of rimabotulinumtoxinB, consult with your doctor to understand the risks and benefits of treatment. Make sure you understand the risks and benefits before undergoing treatment.

Limitations of current research

Research on rimabotulinumtoxinB is still limited, and more studies are needed to fully understand its efficacy and side effects. In particular, further research is needed to determine the reasons why rimabotulinumtoxinB may cause more side effects than botulinum toxin type A and to identify methods for reducing side effects.

Future research directions

Future research should focus on more detailed investigations into the efficacy and side effects of rimabotulinumtoxinB. Studies comparing the efficacy and side effects of rimabotulinumtoxinB to botulinum toxin type A are particularly needed. Research is also needed to explore methods for reducing the side effects of rimabotulinumtoxinB.

Conclusion

RimabotulinumtoxinB is a promising alternative treatment for patients who have developed resistance to botulinum toxin type A or who cannot use botulinum toxin type A. However, rimabotulinumtoxinB may cause more side effects than botulinum toxin type A. Before considering the use of rimabotulinumtoxinB, consult with your doctor to understand the risks and benefits of treatment. Make sure you understand the risks and benefits before undergoing treatment.

Keywords
Benefit Keywords
BoNT/B efficacy
1
Treats sialorrhea
2
Blepharospasm treatment
Cervical dystonia treatment
Facial lines treatment
Focal dystonia treatment
Hemifacial spasm treatment
Hyperhidrosis treatment
Sialorrhea treatment
Spasticity treatment
3
Drooling reduction
4
Quality of life improvement
Sweating reduction
5
Cervical dystonia treatment
6
Hyperhidrosis treatment
7
Reduced sialorrhea
9
Shoulder pain relief
10
Sialorrhea Treatment
11
Improves quality of life
Reduces drooling
12
Reduced sialorrhea
13
Reduced detrusor overactivity
14
Spasm relief
15
Focal dystonia treatment
Spasticity treatment
16
Overactive bladder treatment
Quality of life improvement
17
Treatment of cervical dystonia
18
Improved therapy participation
Reduced drooling
20
Safe and effective
Treatment of focal dystonia
21
Blepharospasm treatment
Cervical dystonia treatment
Frey's syndrome treatment
Spasmodic dysphonia treatment
22
Focal dystonia treatment
23
Detrusor hyperreflexia treatment
24
Dynamic rhytides treatment
25
Reduced pain
Reduced spasticity
26
Cervical Dystonia Treatment
Hyperhidrosis Treatment
27
Reduced wrinkles
28
Treat cervical dystonia
29
Risk Keywords
BoNT/A resistance
1
Autonomic side effects
Immunogenicity
Painful injections
3
Dry mouth
Viscous saliva
4
Stiffness
5
Excessive cost
Side effects
Suboptimal response
Travel burden
6
Muscle weakness
7
Flu-like symptoms
8
Dense saliva
Difficulty swallowing
Xerostomia
9
Parotitis
Viscous saliva
12
Chewing weakness
Local pain
Respiratory infection
Viscous saliva
13
Autonomic side effects
Systemic spread
14
Blurred vision
Dry eye
Dry mouth
Exposure keratitis
Facial droop
Pain on injection
Ptosis
15
Autonomic side effects
17
Dry mouth
Dysphagia
Visual disturbances
18
Therapy failure
19
Neutralizing antibodies
21
Autonomic Side Effects
Dry Mouth
27
Painful injection
28
Autonomic side effects
Dry mouth
29
Literature analysis of 29 papers
Positive Content
27
Neutral Content
1
Negative Content
1
Article Type
4
0
0
6
29
1.

Transient Improvement after Switch to Low Doses of RimabotulinumtoxinB in Patients Resistant to AbobotulinumtoxinA.

Author: HefterHarald, SamadzadehSara, MollMarek

BoNT/B efficacy
BoNT/A resistance

This study compared the clinical effect of rimabotulinumtoxinB to abobotulinumtoxinA in patients resistant to BoNT/A.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

2.

Botulinum Toxin A and B in sialorrhea: Long-term data and literature overview.

Author: PetraccaMartina, GuidubaldiArianna, RicciardiLucia, IalongoTàmara, Del GrandeAlessandra, MulasDelia, Di StasioEnrico, BentivoglioAnna Rita

Treats sialorrhea

Botulinum Toxin has been shown to be effective and safe for treating sialorrhea. This retrospective trial investigates the long-term safety and efficacy of both abobotulinumtoxinA and rimabotulinumtoxinB ultrasound-guided injections for sialorrhea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Clinical differences between botulinum neurotoxin type A and B.

Author: BentivoglioAnna Rita, Del GrandeAlessandra, PetraccaMartina, IalongoTamara, RicciardiLucia

Blepharospasm treatment
Cervical dystonia treatment
Facial lines treatment
Focal dystonia treatment
Hemifacial spasm treatment
Hyperhidrosis treatment
Sialorrhea treatment
Spasticity treatment
Autonomic side effects
Immunogenicity
Painful injections

This review compared the safety and efficacy of different botulinum neurotoxin (BoNT) products, including onabotulinumtoxinA (A/Ona), abobotulinumtoxinA (A/Abo), incobotulinumtoxinA (A/Inco), and rimabotulinumtoxinB (B/Rima), in various clinical indications.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Repeated treatments of drooling with botulinum toxin B in neurology.

Author: MøllerE, DaugaardD, HolmO, WingeK, BardowA, LykkeaaJ, BelhageB, BakkeM

Drooling reduction
Dry mouth
Viscous saliva

Botulinum toxin type B (BoNT-B) treatment resulted in marked reduction of drooling and saliva flow rate with some relapse after 12 weeks. The efficacy of repeated BoNT-B may fade with time.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

5.

Botulinum toxin B in the treatment of craniofacial hyperhidrosis.

Author: KarlqvistM, RosellK, RystedtA, HymneliusK, SwartlingC

Quality of life improvement
Sweating reduction
Stiffness

Botulinum toxin B (Btx B) is a safe and effective treatment in craniofacial hyperhidrosis improving quality of life and reducing extreme sweating.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Continuation of long-term care for cervical dystonia at an academic movement disorders clinic.

Author: GillChandler E, ManusNeil D, PelsterMichael W, CookJason A, TitleWallace, MolinariAnna L, CharlesDavid

Cervical dystonia treatment
Excessive cost
Side effects
Suboptimal response
Travel burden

Cervical dystonia (CD) is a neurological movement disorder. This study investigated the treatment experiences of patients with CD who received care at a movement disorders clinic, finding that a significant number of patients discontinued care due to high costs and travel burden.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Flu-like symptoms following botulinum toxin therapy.

Author: Baizabal-CarvalloJose F, JankovicJoseph, PappertEric

Flu-like symptoms

Flu-like symptoms (FLS) have been reported in 1.7-20% of patients treated with botulinum toxin (BoNT) type A and in 5-55% of patients treated with BoNT type B. Most patients experience mild to moderate symptoms that last less than 2 weeks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Botulinum toxin type B for sialorrhoea in children with cerebral palsy: a randomized trial comparing three doses.

Author: BascianiMario, Di RienzoFilomena, FontanaAndrea, CopettiMassimiliano, PellegriniFabio, IntisoDomenico

Reduced sialorrhea
Dense saliva
Difficulty swallowing
Xerostomia

A 3000 MU injection of botulinum toxin type B into the salivary glands significantly improved sialorrhea in children with cerebral palsy. Higher doses did not produce greater benefit and were associated with more side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Clinical effectiveness of botulinum toxin type B in the treatment of subacromial bursitis or shoulder impingement syndrome.

Author: LeeJung Hwan, LeeSang-Ho, SongSun Hong

Shoulder pain relief

This study compared the clinical effectiveness of botulinum toxin type B with steroid injections for pain relief in patients with subacromial bursitis or shoulder impingement syndrome. The study found that botulinum toxin type B showed promising effectiveness, offering a potential alternative to steroid injections, which often require repeated administrations and can lead to adverse effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Botulinum toxin B as an effective and safe treatment for neuroleptic-induced sialorrhea.

Author: SteinlechnerSusanne, KleinChristine, MoserAndreas, LencerRebekka, HagenahJohann

Sialorrhea Treatment

Botulinum toxin type B has shown promise in treating severe sialorrhea, a common side effect of neuroleptic drugs like clozapine, as well as in neurological disorders such as Parkinson's disease (PD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Successful treatment of drooling in children with neurological disorders with botulinum toxin A or B.

Author: WilkenB, AslamiB, BackesH

Improves quality of life
Reduces drooling
Parotitis
Viscous saliva

Drooling is a common and severe problem in children with neurological disorders. Botulinum toxin injection into the parotid and submandibular glands has emerged as a safe and effective treatment option for reducing excessive sialorrhea. This study evaluated the efficacy and safety of both botulinum toxin A and B in 30 children with cerebral palsy or neurodegenerative disorders.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Botulinum toxin type-B improves sialorrhea and quality of life in bulbaronset amyotrophic lateral sclerosis.

Author: CostaJoão, RochaMaria Luz, FerreiraJoaquim, EvangelistaTeresinha, CoelhoMiguel, de CarvalhoMamede

Reduced sialorrhea
Chewing weakness
Local pain
Respiratory infection
Viscous saliva

Botulinum toxin type B injections were effective and safe in treating sialorrhea in patients with bulbar-onset amyotrophic lateral sclerosis. Seventy-five percent of patients showed improvement of more than 50% after one month of treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Autonomic side effects of Botulinum toxin Type B intravesical injections: report of 4 cases and review of the literature.

Author: GheiM, MarajB H, NathanS, Malone-LeeJ, MillerR

Reduced detrusor overactivity
Autonomic side effects
Systemic spread

This study reports four cases of autonomic side effects following intravesical injections of Botulinum toxin type B (BT-B), suggesting clinically relevant systemic spread of the toxin, a side effect not typically seen with BT-A.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Myobloc for the treatment of benign essential blepharospasm in patients refractory to botox.

Author: DuttonJonathan J, WhiteJeffrey J, RichardMichael J

Spasm relief
Blurred vision
Dry eye
Dry mouth
Exposure keratitis
Facial droop
Pain on injection
Ptosis

Botulinum toxin B was effective in treating essential blepharospasm or hemifacial spasm in patients who had become refractory to botulinum toxin A, but the duration of effect was shorter and side effects occurred at a higher rate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Effects of botulinum toxin B on refractory detrusor overactivity: a randomized, double-blind, placebo controlled, crossover trial.

Author: GheiM, MarajB H, MillerR, NathanS, O'SullivanC, FowlerC J, ShahP J R, Malone-LeeJ

Overactive bladder treatment
Quality of life improvement
Autonomic side effects

This study found that botulinum toxin B is effective in the treatment of overactive bladder in a double-blind, placebo controlled, crossover study. The study found that botulinum toxin B caused a significant improvement in voided volume, urinary frequency, incontinence episodes, and quality of life.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Visual system side effects caused by parasympathetic dysfunction after botulinum toxin type B injections.

Author: DubowJordan, KimAngela, LeikinJerrold, CumpstonKirk, BryantSean, RezakMichael

Treatment of cervical dystonia
Dry mouth
Dysphagia
Visual disturbances

Botulinum toxin type B (BTX-B) is a safe and effective alternative to BTX-A for patients resistant to BTX-A, but rare cases of parasympathetic dysfunction of the visual system have been reported following injections at remote sites.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Botulinum toxin type B de novo therapy of cervical dystonia: frequency of antibody induced therapy failure.

Author: DresslerDirk, BigalkeHans

Therapy failure

This study investigated the risk of BT-B-AB-induced therapy failure in patients who were exposed to botulinum toxin for the first time. Four out of nine patients experienced complete therapy failure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Quantitative reduction of saliva production with botulinum toxin type B injection into the salivary glands.

Author: Turk-GonzalesMelissa, OddersonIb R

Improved therapy participation
Reduced drooling

This case report describes the successful treatment of drooling in a patient with a brainstem stroke using botulinum toxin type B injections into the salivary glands. The procedure resulted in a significant decrease in saliva production and improvement in the patient's quality of life.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

[Treatment of focal dystonia with botulinum toxin A].

Author: SojerM, WisselJ, MüllerJ, PoeweW

Safe and effective
Treatment of focal dystonia
Neutralizing antibodies

Botulinum toxin A (BtxA) injections are a safe and effective treatment for focal dystonia, a condition that causes involuntary muscle contractions. BtxA injections are commonly used to treat cervical dystonia and blepharospasm. In up to 5% of patients, BtxA injections can lead to the development of neutralizing antibodies, which can reduce the effectiveness of the treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

22.

[First use of botulinum toxin type B in ENT patients with secondary therapy failure of botulinum toxin type A].

Author: Guntinas-LichiusO

Blepharospasm treatment
Cervical dystonia treatment
Frey's syndrome treatment
Spasmodic dysphonia treatment

This report describes the successful treatment of three patients with secondary failure of botulinum toxin type A (BT-A) injections using botulinum toxin type B (BT-B).

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

23.

[Botulinum toxin type B in the management of dystonia non-responsive to botulinum toxin type A].

Author: CardosoFrancisco

Focal dystonia treatment

Botulinum toxin (BTX) is a common treatment for focal dystonia, but some patients lose response after repeated injections. This abstract describes the author's experience using BTX type B as an alternative for patients who no longer respond to BTX type A.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Portuguese

24.

Use of botulinum toxin type B for the treatment of detrusor hyperreflexia in a patient with multiple sclerosis: a case report.

Author: DykstraDennis D, PryorJon, GoldishGary

Detrusor hyperreflexia treatment

This case report describes the successful treatment of detrusor hyperreflexia in a patient with multiple sclerosis using botulinum toxin type B injections.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

25.

Botulinum toxin type B for dynamic glabellar rhytides refractory to botulinum toxin type A.

Author: AlsterTina S, LuptonJason R

Dynamic rhytides treatment

Botulinum toxin type B (BTX-B; Myobloc) is a potential alternative to botulinum toxin type A (BTX-A; Botox) for the treatment of dynamic rhytides. BTX-B is structurally similar to BTX-A and appears to produce equivalent muscular paralysis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

26.

Treatment of spasticity with botulinum toxin.

Author: O'BrienChristopher F

Reduced pain
Reduced spasticity

This study reviewed the use of botulinum toxin therapy for the treatment of spasticity, a condition characterized by abnormal muscle contraction. Botulinum toxin therapy is effective in reducing spasticity and pain and is safe for pediatric patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

28.

Botulinum toxin type B (MyoBloc) in the management of hyperkinetic facial lines.

Author: RamirezAlexander L, ReeckJay, MaasCorey S

Reduced wrinkles
Painful injection

This study evaluated the safety and efficacy of botulinum toxin type B (BTX-B) in the management of hyperfunctional facial lines in 24 patients. Patients were treated with 400 to 800 units BTX-B in the corrugator, orbicularis oculi, or frontalis. BTX-B is a safe and effective technique to eliminate wrinkles. Further studies are needed to elucidate dosage and duration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

[Initial experiences with clinical use of botulinum toxin type B].

Author: DresslerD, BeneckeR

Treat cervical dystonia
Autonomic side effects
Dry mouth

Botulinum toxin type B (BT-B) is a successful treatment for cervical dystonia (CD) in patients who have developed antibodies against botulinum toxin type A. BT-B can also be effective for de novo CD patients, but it produces more systemic autonomic side effects than BT-A.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

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