Side Effects of rivastigmine transdermal patch: A Synthesis of Findings from 5 Studies

  1. Home
  2. Side Effects of rivastigmine transdermal patch
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of rivastigmine transdermal patch: A Synthesis of Findings from 5 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of rivastigmine transdermal patch: A Synthesis of Findings from 5 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Multiple studies have shown that the rivastigmine transdermal patch provides similar efficacy to oral rivastigmine with a lower incidence of gastrointestinal side effects. 4 , 5 , 3 The rivastigmine patch provides a continuous delivery of the drug through the skin into the bloodstream, avoiding the fluctuations in plasma concentration associated with oral administration. 4 , 5 This may contribute to improved patient compliance. 5

Reasons for Side Effects

Oral cholinesterase inhibitors are associated with gastrointestinal side effects, which are believed to be caused by a rapid increase in brain acetylcholine levels. 4 The rivastigmine patch delivers the drug slowly and steadily through the skin, avoiding rapid changes in brain acetylcholine levels. 4

Common Side Effects

Nausea

Nausea was reported in up to 3.2% of patients switching to the rivastigmine patch from oral rivastigmine. 2

Vomiting

Vomiting was reported in up to 1.9% of patients switching to the rivastigmine patch from oral rivastigmine. 2

Skin Rash

Skin rash has been reported as a side effect of rivastigmine patch. 3

Side Effects Management

Nausea and Vomiting

For patients experiencing nausea and vomiting, adjusting the time of medication administration, such as taking it before meals, may reduce the symptoms. 4 Consulting with a doctor for anti-nausea medications may also be helpful. 4

Skin Rash

Consult a doctor if skin rash occurs. 3

Comparison Between Studies

Commonalities

Multiple studies have shown that the rivastigmine transdermal patch provides similar efficacy to oral rivastigmine with a lower incidence of gastrointestinal side effects. 4 , 5 , 3 The rivastigmine patch provides a continuous delivery of the drug through the skin into the bloodstream, avoiding the fluctuations in plasma concentration associated with oral administration. 4 , 5

Differences

The incidence of side effects associated with rivastigmine patch varies across studies. 2 This could be attributed to differences in study design and patient populations. 2

Points to Note for Real-World Application

Multiple studies have shown that the rivastigmine transdermal patch provides similar efficacy to oral rivastigmine with a lower incidence of gastrointestinal side effects. 4 , 5 , 3 However, side effect incidence can vary between individuals. 2 Therefore, it is crucial to consult a doctor before using the rivastigmine transdermal patch and follow their instructions for proper use based on your individual condition. 4

Limitations of Current Research

Research on the rivastigmine transdermal patch is still limited in number, and further studies are needed to evaluate its long-term safety and efficacy. 5

Future Research Directions

Long-term clinical trials are necessary to assess the long-term safety and efficacy of the rivastigmine transdermal patch. 5 Further research is also needed to determine the duration of the patch's effectiveness and which patients benefit most from it. 5

Conclusion

Multiple studies have shown that the rivastigmine transdermal patch provides similar efficacy to oral rivastigmine with a lower incidence of gastrointestinal side effects. 4 , 5 , 3 The rivastigmine transdermal patch has the potential to be a safer and more effective option for the treatment of Alzheimer's disease. 5 However, side effect incidence can vary between individuals, so it is crucial to consult a doctor before using the rivastigmine transdermal patch and follow their instructions for proper use based on your individual condition. 4

Literature analysis of 5 papers
Positive Content
5
Neutral Content
0
Negative Content
0
Article Type
1
0
0
4
5
1.

Impact of rivastigmine patch and capsules on activities of daily living in Alzheimer's disease.

Author: GrossbergGeorge, MengXiangyi, OlinJason T

Improved ADLs

Rivastigmine patches and capsules demonstrated significant improvement in activities of daily living (ADLs) in patients with probable Alzheimer's disease (AD) compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Switching from oral cholinesterase inhibitors to the rivastigmine transdermal patch.

Author: SadowskyC, PerezJ A Davila, BouchardR W, GoodmanI, TekinS

Reduced nausea
Reduced vomiting

Switching from oral cholinesterase inhibitors to transdermal rivastigmine patches appears well-tolerated, with low rates of nausea and vomiting.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Use of rivastigmine transdermal patch in the treatment of Alzheimer's disease.

Author: WinbladBengt, MachadoJoão Carlos

Reduce nausea and vomiting
Treat dementia

Rivastigmine, a cholinesterase inhibitor for dementia treatment, exhibits a dose-response relationship, with higher doses providing greater efficacy. The rivastigmine patch offers continuous delivery, providing similar efficacy to high-dose capsules, but with fewer side effects like nausea and vomiting.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Pharmacokinetic rationale for the rivastigmine patch.

Author: CummingsJeffrey, LefèvreGilbert, SmallGary, Appel-DingemanseSilke

Alzheimer's treatment
Parkinson's treatment
Gastrointestinal side effects

Rivastigmine is a cholinesterase inhibitor approved for the symptomatic treatment of dementia associated with Alzheimer disease (AD) and Parkinson disease (PD). A recently developed rivastigmine transdermal patch may have the potential to reduce side effects, such as nausea and vomiting, while permitting similar exposure to the highest doses of capsules.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Drug profile: transdermal rivastigmine patch in the treatment of Alzheimer disease.

Author: EmreMurat, BernabeiRoberto, BlesaRafael, BullockRoger, CunhaLuis, DaniëlsHugo, DziadulewiczEdward, FörstlHans, FrölichLutz, GabryelewiczTomasz, LevinOleg, LindesayJames, Martínez-LagePablo, MonschAndreas, TsolakiMagda, van LaarTeus

Improved patient compliance
Reduced side effects
Treatment of AD

This study reviewed the current literature on rivastigmine patch for the treatment of Alzheimer disease. The patch provides continuous delivery of drug through the skin into the bloodstream, avoiding fluctuations in plasma concentration associated with oral administration. This pharmacokinetic profile is associated with reduced side effects, resulting in easier access to expected target doses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.