Effects of simethicone: A Synthesis of Findings from 28 Studies

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Original Abstract of the Article

Main Research Findings

Simethicone is an anti-foaming agent that is often used to improve visualization during endoscopic procedures. Multiple studies have suggested that simethicone can improve visualization in various endoscopic procedures, including upper gastrointestinal endoscopy, colonoscopy, and capsule endoscopy. 28 , 5 , 23 , 7 , 3 , 18 , 2 , 10 . Simethicone can be used alone or in combination with other agents, such as N-acetylcysteine. 28 , 8 , 27 , 6 . The effectiveness of simethicone may vary depending on the administration method and dosage before the endoscopic procedure, and further research is needed. 3 .

Benefits and Risks

Benefits Summary

Simethicone can improve visualization during endoscopic procedures, potentially increasing the detection rate of lesions. 28 , 5 , 23 , 7 , 3 , 18 , 2 , 10 . Simethicone can also reduce discomfort during endoscopic procedures. 13 . Moreover, simethicone can potentially shorten the procedure time of endoscopic examinations. 28 .

Risks Summary

While generally considered safe, simethicone can cause side effects, although these are rare. Side effects include indigestion, constipation, and abdominal pain. 19 , 5 . Simethicone can also create deposits within the scope channels, potentially increasing the risk of infections. 25 . However, the use of simethicone should be limited to the minimum amount necessary to minimize the risk of infections. 25 .

Comparison of Studies

Similarities Between Studies

Many studies suggest that simethicone is effective in improving visualization during endoscopic procedures. 28 , 5 , 23 , 7 , 3 , 18 , 2 , 10 . Another common finding is that simethicone may shorten the procedure time of endoscopic examinations. 28 .

Differences Between Studies

The effectiveness and side effects of simethicone, as well as the dosage and method of administration, may vary across different studies. 28 , 25 , 5 , 3 . Therefore, it is important to consult with a physician before using simethicone during endoscopic procedures.

Consistency and Discrepancies in the Results

There is variability in the effectiveness of simethicone across different studies. 19 . Therefore, it is not possible to definitively say whether simethicone is effective for endoscopic procedures. Furthermore, the effectiveness of simethicone may vary depending on the dosage, method of administration, and type of endoscopic procedure. 3 . Further research is needed in this area.

Application Notes for Everyday Life

Simethicone is a medication that may improve visualization during endoscopic procedures. 28 , 5 , 23 , 7 , 3 , 18 , 2 , 10 . However, simethicone does not work for everyone. 19 . Additionally, simethicone can potentially cause side effects. 19 . Therefore, it is crucial to consult with a doctor before using simethicone.

Limitations of Current Research

Research on simethicone is still limited. 19 . In particular, the long-term effects of simethicone are still unknown. 19 . Furthermore, the effectiveness of simethicone may vary depending on the dosage, method of administration, and type of endoscopic procedure. 3 . Therefore, more research is needed in this area.

Future Research Directions

Future research on simethicone should focus on understanding the long-term effects of simethicone, as well as identifying the optimal dosage and method of administration. 19 , 3 . Additionally, research is needed to investigate how simethicone affects different endoscopic procedures. 19 .

Conclusion

Simethicone is a potential medication that can improve visualization during endoscopic procedures. 28 , 5 , 23 , 7 , 3 , 18 , 2 , 10 . However, simethicone does not work for everyone. 19 . Additionally, it is important to be aware of the potential side effects of simethicone. 19 . Therefore, consult with your doctor before using simethicone.

Literature analysis of 28 papers
Positive Content
26
Neutral Content
1
Negative Content
1
Article Type
11
4
5
6
28
1.

Effects of a nine-strain bacterial synbiotic compared to simethicone in colicky babies - an open-label randomised study.

Author: PiątekJ, BernatekM, KraussH, WojciechowskaM, Chęcińska-MaciejewskaZ, KaczmarekP, SommermeyerH

Infantile colic relief

This study found that a multi-strain synbiotic was more effective than simethicone in reducing crying in babies with colic.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Polyethylene glycol plus simethicone in small-bowel preparation for capsule endoscopy.

Author: SpadaCristiano, RiccioniMaria E, FamiliariPietro, SperaGianluca, PirozziGiuseppe A, MarcheseMichele, BizzottoAlessandra, IngrossoMarcello, CostamagnaGuido

VCE preparation

The use of 2l of a polyethylene glycol and simethicone solution before VCE is not supported.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Optimal timing of simethicone administration prior to upper endoscopy: A multicenter, single-blind, randomized controlled trial.

Author: BeaufortI N, VerbeekR E, BosmanJ H, Al-TomaA, BogteA, Alvarez HerreroL, WeustenB L A M

Improved mucosal visibility

This randomized study found that early simethicone administration before upper endoscopy, either as a single dose or split-dose regimen, improved mucosal visibility, particularly in the stomach.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Formulation development of sugar free antacid chewable tablets for diabetes induced acidity in patients.

Author: KhanMehwish, RehmanHina, AyazSultan, QamarFatima, OwaisAymen, SanaAisha, NaveedSafila

Antacid treatment

A sugar-free, chewable antacid tablet was developed for diabetic patients with acid reflux. The formulation is stable and suitable for further safety and efficacy studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

A prospective randomized controlled trial comparing simethicone, N-acetylcysteine, sodium bicarbonate and peppermint for visualization in upper gastrointestinal endoscopy.

Author: MahawongkajitPrasit, KanlerdAmonpon

EGD visualization

This study compared the effects of simethicone, N-acetylcysteine, sodium bicarbonate, and peppermint as pre-medications for improving visualization during esophagogastroduodenoscopy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Does Premedication with Mucolytic Agents Improve Mucosal Visualization during Oesophagogastroduodenoscopy: A Systematic Review and Meta-Analysis.

Author: BurkeEoghan, HarkinsPatricia, MoriartyFrank, AhmedIbrahim

Mucosal visibility
Gastric cancer

This systematic review and meta-analysis of 13 studies found that premedication with mucolytic agents prior to routine oesophagogastroduodenoscopy (OGD) improved total mucosal visibility scores (TMVS). Simethicone was the most effective agent, with a dose of 133 mg being optimal.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Pain-relieving agents for infantile colic.

Author: BiagioliElena, TarascoValentina, LinguaCarla, MojaLorenzo, SavinoFrancesco

Pain relief for infantile colic

Infantile colic is a common disorder in the first months of life, affecting somewhere between 4% and 28% of infants worldwide. This review describes the use of pain-relieving agents to reduce crying episodes and severity of symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

A randomized controlled trial of high volume simethicone to improve visualization during capsule endoscopy.

Author: SeyMichael, YanBrian, McDonaldCassandra, SegalDan, FriedlandJoshua, PukaKlajdi, JairathVipul

Diagnostic yield
Improved cleansing

A higher volume of simethicone may improve cleansing and diagnostic yield in capsule endoscopy, especially in the distal small bowel.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Dietary modifications for infantile colic.

Author: GordonMorris, BiagioliElena, SorrentiMiriam, LinguaCarla, MojaLorenzo, BanksShel Sc, CerattoSimone, SavinoFrancesco

Infantile colic

Infantile colic is a common condition in infants characterized by excessive crying for at least 3 hours per day, on at least 3 days per week, for at least 3 weeks. The aetiopathogenesis of infantile colic is unclear but thought to be multifactorial. This review discusses the current understanding of infantile colic, including its prevalence, aetiology, and management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

A new low-volume isosmotic polyethylene glycol solution plus bisacodyl versus split-dose 4 L polyethylene glycol for bowel cleansing prior to colonoscopy: a randomised controlled trial.

Author: CesaroPaola, HassanCesare, SpadaCristiano, PetruzzielloLucio, VitaleGiovanna, CostamagnaGuido

Improved patient compliance

This study discusses the development of a new low-volume polyethylene glycol preparation for colon cleansing before colonoscopy. This new formula aims to improve patient compliance and tolerability by reducing the volume and taste issues associated with traditional preparations.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Alverine citrate plus simethicone reduces cecal intubation time in colonoscopy - a randomized study.

Author: AltintaşEngin, UçbilekEnver, SezginOrhan, SayiciYasin

Improve bowel cleanliness
Reduce intubation time
Reduce spasm

This study investigated the effects of alverine citrate plus simethicone on cecal intubation time, colonic spasm, and bowel cleanliness during colonoscopy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Improving quality of colonoscopy by adding simethicone to sodium phosphate bowel preparation.

Author: TongprasertSasinee, SobhonslidsukAbhasnee, RattanasiriSasivimol

Colonoscopy visibility
Patient satisfaction

This study found that adding simethicone to sodium phosphate bowel preparation significantly improved colonoscopy visibility by diminishing air bubbles. Endoscopist and patient satisfaction were also increased, but there was no difference in the total duration of the procedure or side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Should bowel preparation, antifoaming agents, or prokinetics be used before video capsule endoscopy? A systematic review and meta-analysis.

Author: KotwalVikram S, AttarBashar M, GuptaSaurabh, AgarwalRajender

Improved visualization
Increased diagnostic yield
Needs more research

A systematic review and meta-analysis of 15 randomized-controlled trials studying bowel preparation regimes for small bowel video capsule endoscopy found that a combination of polyethylene glycol (PEG) and simethicone appeared to be the best approach for improving visualization quality and diagnostic yield. Prokinetics were not found to improve the completion rate of VCE. Further research is needed to determine the ideal dose of PEG and timing of bowel preparation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Improving of bowel cleansing effect for polyethylene glycol with ascorbic acid using simethicone: A randomized controlled trial.

Author: YooIn Kyung, JeenYoon Tae, KangSeung Hun, LeeJae Hyung, KimSeung Han, LeeJae Min, ChoiHyuk Soon, KimEun Sun, KeumBora, ChunHoon Jai, LeeHong Sik, KimChang Duck

Bowel preparation
Compliance

This CONSORT-prospective, randomized, observer-blinded, controlled trial aims to compare the quality of bowel preparation and compliance between polyethylene glycol with ascorbic acid (PEG-Asc) users and PEG-Asc plus simethicone users.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Systematic review and meta-analysis of randomized controlled trials of Simethicone for gastrointestinal endoscopic visibility.

Author: WuLiucheng, CaoYunfei, LiaoCun, HuangJiahao, GaoFeng

Improved SBVQ
Controversial diagnostic yield

A meta-analysis of 13 studies on the use of Simethicone for endoscopy revealed that supplemental Simethicone improves small bowel visualization quality, especially for patients without purgatives, but does not affect capsule endoscopy completion rates. It also decreases air bubbles in the colonic lumen without improving bowel preparation. The impact of Simethicone on diagnostic yield remains controversial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

[Efficacy of alverina citrate and simethicone combination in abdominal pain and discomfort of irritable bowel syndrome].

Author: WittmannT, ParadovskyL, DucrotteP, BuenoL, Andro-DelestrainM C T

Reduced abdominal pain

The combination of alverina citrate and simethicone was significantly more effective in patients with IBS compared to placebo in reducing abdominal pain or discomfort.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

21.

Systematic review and meta-analysis of colon cleansing preparations in patients with inflammatory bowel disease.

Author: RestelliniSophie, KheradOmar, BessissowTalat, MénardCharles, MartelMyriam, Taheri TanjaniMaryam, LakatosPeter L, BarkunAlan N

Improved bowel cleansing
Side effects

Low-volume polyethylene glycol (PEG) regimens were as effective as high-volume PEG regimens in cleansing the colon of patients with inflammatory bowel disease. Low-volume regimens were also associated with greater willingness to repeat the procedure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Combination of a Probiotic and an Antispasmodic Increases Quality of Life and Reduces Symptoms in Patients with Irritable Bowel Syndrome: A Pilot Study.

Author: Barraza-OrtizDiego A, Pérez-LópezNuria, Medina-LópezVíctor M, Minero-AlfaroJosé I, Zamarripa-DorseyFelipe, Fernández-MartínezNerina Del C, Llorente-RamónAlberto, Ramos-AguilarGustavo A

IBS management

This pilot study assessed the efficacy of the probiotic formulation i3.1 with or without the addition of the antispasmodic alverine/simethicone in improving IBS-related quality of life and reducing abdominal pain and diarrhea in patients with IBS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

The effectiveness of simethicone in improving visibility during colonoscopy.

Author: ParkJae Jun, LeeSang Kil, JangJae Young, KimHyo Jong, KimNam Hoon

Bubble formation prevention
Colonoscopy visibility improvement

Simethicone taken after polyethylene glycol or sodium phosphate bowel preparation significantly reduced colonic bubble formation during colonoscopy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Adjuncts to colonic cleansing before colonoscopy.

Author: ParkSanghoon, LimYun Jeong

Improved bowel cleansing
Drug interactions

This review examines the use of adjunctive agents to improve colonic cleansing effectiveness during colonoscopy preparation. While no single agent has completely overcome limitations of the gold standard method, several promising options, such as bisacodyl, magnesium citrate, senna, simethicone, metoclopramide, and prokinetics, can enhance the efficiency of traditional bowel preparation agents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Efficacy of artichoke and ginger extracts with simethicone to treat gastrointestinal symptoms in endurance athletes: a pilot study.

Author: DrobnicFranchek, FontsSergi, García-AldayIker, PetrangoliniGiovanna, RivaAntonella, FrattiniElisabetta, AllegriniPietro, TogniStefano, VitaleJacopo

GI symptom reduction

A combination of artichoke leaves and ginger root extracts, with simethicone, effectively reduced digestive discomfort and alteration of gastric motility in endurance athletes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

27.

Premedication with N-acetylcysteine and simethicone improves mucosal visualization during gastroscopy: a randomized, controlled, endoscopist-blinded study.

Author: NealeJames R, JamesShirley, CallaghanJames, PatelPraful

Improved mucosal visualization

This study investigated the use of a premedication solution containing N-acetylcysteine and simethicone to improve mucosal visualization during diagnostic gastroscopy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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