Effects of tavaborole topical: A Synthesis of Findings from 12 Studies

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Original Abstract of the Article

Major research findings

Tavaborole topical solution, a boron-based antifungal agent, has shown effectiveness in treating toenail onychomycosis, a fungal nail infection. 11 highlights the efficacy of tavaborole topical solution in treating toenail onychomycosis. Furthermore, 10 emphasizes that tavaborole topical solution is safe and effective in treating toenail onychomycosis. 8 suggests that the benefits of tavaborole topical solution are sustained over the long term. 12 also supports the efficacy and safety of tavaborole topical solution in treating toenail onychomycosis.

7 demonstrates that tavaborole topical solution can penetrate through nail polish and still effectively target the fungi responsible for onychomycosis. This finding suggests that patients who wish to conceal their infection with nail polish can still benefit from the use of tavaborole topical solution.

Moreover, 9 indicates that tavaborole topical solution does not negatively affect the appearance of nail polish. This finding suggests that tavaborole topical solution provides effective treatment for toenail onychomycosis without compromising the aesthetic appeal of wearing nail polish.

Benefits and risks

Benefits summary

Tavaborole topical solution has been shown to be an effective treatment for toenail onychomycosis. 11 , 10 , 8 , 12

Furthermore, tavaborole topical solution can be effective even when applied over nail polish. 7

Additionally, tavaborole topical solution does not affect the appearance of nail polish. 9

Risks summary

While generally safe, tavaborole topical solution has been reported to cause adverse events such as ingrown toenail, exfoliation, erythema, and dermatitis in a small proportion of patients. 10

Comparison between studies

Commonalities of studies

These studies consistently demonstrate the effectiveness of tavaborole topical solution in treating toenail onychomycosis.

Differences between studies

The studies differ in aspects such as the duration of the study, the number of participants, the specific evaluation methods, and the application method of the tavaborole topical solution.

Consistency and contradictions in results

The research suggests that tavaborole topical solution is a safe and effective treatment for toenail onychomycosis. However, it is crucial to note that some patients may experience side effects, emphasizing the importance of careful monitoring and communication with healthcare professionals.

Considerations for real-life applications

While tavaborole topical solution is an effective treatment option, it is important to remember that it may not be effective for all individuals, and side effects are possible. It is recommended to consult with a healthcare professional for personalized advice and to follow their instructions carefully when using tavaborole topical solution.

Limitations of current research

The studies included in this review may have limitations regarding long-term effects of tavaborole topical solution and its comparative effectiveness to other treatments.

Future research directions

Further research is needed to explore the long-term effects of tavaborole topical solution and compare its efficacy to other existing treatments for toenail onychomycosis.

Conclusion

Tavaborole topical solution presents a promising treatment option for toenail onychomycosis. While it demonstrates effectiveness and safety, it's crucial to consult with a healthcare professional for personalized advice and to be aware of potential side effects.

Literature analysis of 12 papers
Positive Content
11
Neutral Content
1
Negative Content
0
Article Type
7
1
2
1
12
1.

A randomised, placebo-controlled trial comparing the effects of tapentadol and oxycodone on gastrointestinal and colonic transit in healthy humans.

Author: JeongI D, CamilleriM, ShinA, IturrinoJ, BoldinghA, BusciglioI, BurtonD, RyksM, RhotenD, ZinsmeisterA R

Pain relief
GI side effects

This study investigates the effects of tapentadol, a mu-opioid receptor agonist and norepinephrine reuptake inhibitor, on gastrointestinal and colonic transit. The study aims to understand the impact of tapentadol on digestion and bowel movements.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Undesired side effects of tapentadol in comparison to oxycodone. A meta-analysis of randomized controlled comparative studies].

Author: MerkerM, DingesG, KochT, KrankeP, MorinA M

Less GI side effects
Pain relief

This study reviewed randomized controlled trials comparing tapentadol and oxycodone for pain management. The objective was to evaluate the relative amount of adverse effects associated with each drug.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : German

3.

Miotic and subject-rated effects of therapeutic doses of tapentadol, tramadol, and hydromorphone in occasional opioid users.

Author: StoopsWilliam W, GlaserPaul E A, RushCraig R

Tapentadol analgesia
Tramadol side effects

Tapentadol, a novel analgesic, produced a profile of positive effects comparable to hydromorphone. Tramadol, another analgesic, produced both positive and negative subject-rated effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Tapentadol versus oxycodone analgesia and side effects after laparoscopic hysterectomy: A randomised controlled trial.

Author: ComelonMarlin, RaederJohan, DrægniTomas, LiengMarit, LenzHarald

Reduced side effects
Synergistic analgesia

Tapentadol, an opioid with a dual mechanism of action, was investigated for its effectiveness in postoperative pain management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Tapentadol results in less deterioration of gastrointestinal function and symptoms than standard opioid therapy in healthy male volunteers.

Author: MarkEsben Bolvig, NedergaardRasmus Bach, HansenTine Maria, NissenThomas Dahl, FrøkjaerJens Brøndum, ScottS Mark, KroghKlaus, DrewesAsbjørn Mohr

Improved pain management
Reduced GI side effects

This study aims to investigate the effects of tapentadol and oxycodone on gastrointestinal motility and side effects, focusing on a more precise assessment of mechanistic effects and comparisons with other opioids or placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

In vitro efficacy of tavaborole topical solution, 5% after penetration through nail polish on ex vivo human fingernails.

Author: GuptaAditya K, VlahovicTracey C, FoleyKelly A, LoweNicole Gellings, TurnerRob, BrownMarc, HallSteve

Onychomycosis treatment

Tavaborole exhibited antifungal activity against Trichophyton rubrum in the presence of nail polish.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Evaluation of the efficacy and safety of tavaborole topical solution, 5%, in the treatment of onychomycosis of the toenail in adults: a pooled analysis of an 8-week, post-study follow-up from two randomized phase 3 studies.

Author: GuptaAditya K, HallSteve, ZaneLee T, LipnerShari R, RichPhoebe

Durable clinical benefit for onychomycosis

Tavaborole topical solution, 5%, appears to provide durable clinical benefit for the treatment of toenail onychomycosis.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Evaluation of the Appearance of Nail Polish Following Daily Treatment of Ex Vivo Human Fingernails With Topical Solutions of Tavaborole or Efinaconazole.

Author: VlahovicTracey C, CoronadoDina, ChandaSanjay, MerchantTejal, ZaneLee T

Onychomycosis treatment

Topical treatments for onychomycosis, such as tavaborole and efinaconazole, can be affected by nail polish. This study evaluated the impact of nail polish on the appearance and efficacy of these treatments. While some color transfer occurred, both treatments remained effective when applied to polished nails.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Tavaborole topical solution, 5% for the treatment of toenail onychomycosis.

Author: ZaneL T, PlattnerJ, ChandaS, CoronadoD, MerchantT, AlleyM R K, GuptaA K

Toenail onychomycosis treatment
Dermatitis
Erythema
Exfoliation
Ingrown toenail

This abstract summarizes preclinical and phase III clinical trial data for tavaborole topical solution, 5%, a novel boron-based antifungal agent indicated for treatment of toenail onychomycosis. Tavaborole was found to be safe and efficacious for treating toenail onychomycosis in clinical trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Efficacy and safety of tavaborole topical solution, 5%, a novel boron-based antifungal agent, for the treatment of toenail onychomycosis: Results from 2 randomized phase-III studies.

Author: ElewskiBoni E, AlyRaza, BaldwinSheryl L, González SotoRemigio F, RichPhoebe, WeisfeldMax, WiltzHector, ZaneLee T, PollakRichard

Onychomycosis treatment

Tavaborole demonstrates a favorable benefit-risk profile in treatment of toenail onychomycosis.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

The efficacy and safety of tavaborole, a novel, boron-based pharmaceutical agent: phase 2 studies conducted for the topical treatment of toenail onychomycosis.

Author: Toledo-BahenaMirna E, BuckoAlicia, Ocampo-CandianiJorge, Herz-RuelasMaira E, JonesTerry M, JarrattMichael T, PollakRichard A, ZaneLee T

Favorable efficacy
Favorable safety
Application site reactions

Three clinical studies of 336 patients with toenail onychomycosis found that tavaborole topical solution demonstrated favorable efficacy and safety. Treatment success rates at day 180 were higher with tavaborole 2.5%, 5.0%, and 7.5% compared to vehicle. Tavaborole 5% showed promising results and was further investigated in phase 3 studies.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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