A randomised, placebo-controlled trial comparing the effects of tapentadol and oxycodone on gastrointestinal and colonic transit in healthy humans.

Author: BoldinghA, BurtonD, BusciglioI, CamilleriM, IturrinoJ, JeongI D, RhotenD, RyksM, ShinA, ZinsmeisterA R

Paper Details 
Original Abstract of the Article :
Tapentadol is a mu-opioid receptor agonist and norepinephrine reuptake inhibitor. In clinical trials, tapentadol provided somatic pain relief comparable to mu-opioids such as oxycodone, with significantly less gastrointestinal adverse effects. The acute effects of tapentadol on gastrointestinal and ...See full text at original site
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引用元:
https://doi.org/10.1111/j.1365-2036.2012.05040.x

データ提供:米国国立医学図書館(NLM)

Tapentadol vs. Oxycodone: A Camel's Journey Through Pain Relief

The desert of pain can be a harsh and unforgiving landscape, and finding effective pain relief is like discovering a refreshing oasis. This research delves into the world of opioid analgesics, comparing the effects of tapentadol and oxycodone on gastrointestinal and colonic transit in healthy volunteers. It's like a camel caravan exploring different paths in the desert, seeking the most comfortable and efficient route to its destination.

A More Comfortable Journey Through the Desert of Pain

The study found that tapentadol, a mu-opioid receptor agonist and norepinephrine reuptake inhibitor, provided comparable pain relief to oxycodone, a traditional mu-opioid agonist, but with fewer gastrointestinal side effects. This is like finding a path through the desert that is not only smooth and safe, but also minimizes the risk of encountering harsh and unpleasant conditions. The research suggests that tapentadol might be a more comfortable and tolerable option for pain management, especially for those who experience gastrointestinal issues with traditional opioids.

Navigating the Desert with Caution

While this research offers promising findings, it's essential to remember that all medications, even those with fewer side effects, can have risks. It's important to consult with a healthcare professional to determine the best course of action for individual needs. Just as camels adapt to the desert environment, we need to be aware of our individual responses to medication and work with our healthcare providers to find the best possible solutions for our pain management needs.

Dr. Camel's Conclusion

This research offers a glimpse into the potential of tapentadol as a more comfortable and tolerable option for pain management. It's like finding a smoother path through the desert of pain, reducing the risk of unpleasant side effects. However, as with any medication, it's essential to consult with a healthcare professional to find the best approach for individual needs. Remember, navigating the desert of pain requires careful planning, open communication, and a willingness to adapt to find the most effective and comfortable journey.

Date :
  1. Date Completed 2014-10-20
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

22348605

DOI: Digital Object Identifier

10.1111/j.1365-2036.2012.05040.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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