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Miotic and subject-rated effects of therapeutic doses of tapentadol, tramadol, and hydromorphone in occasional opioid users.

Author: GlaserPaul E A, RushCraig R, StoopsWilliam W

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tapentadol, a novel analgesic, produced a profile of positive effects comparable to hydromorphone. Tramadol, another analgesic, produced both positive and negative subject-rated effects.
Paper Details　
Original Abstract of the Article :
RATIONALE: Tapentadol is a novel analgesic that activates mu-opioid receptors and blocks norepinephrine reuptake. There is very little information available regarding the non-analgesic pharmacodynamic effects of tapentadol. OBJECTIVES: This outpatient study evaluated the physiological, subject-rate...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/23430163

データ提供：米国国立医学図書館（NLM）

Tapentadol, Tramadol, and Hydromorphone Effects in Occasional Opioid Users

This intriguing study explores the non-analgesic pharmacodynamic effects of tapentadol, a novel analgesic medication, in comparison to two established opioid analgesics, tramadol and hydromorphone. The researchers conducted a double-blind, within-subject study, examining the physiological, subject-rated, and performance effects of these medications in occasional opioid users, aiming to provide a comprehensive understanding of their non-analgesic effects.

Unveiling the Non-Analgesic Effects of Opioid Analgesics

The study reveals that all three drugs produced comparable, time-dependent decreases in pupil diameter, a common physiological effect of opioid medications. The researchers also observed that tapentadol, tramadol, and hydromorphone elicited positive subject-rated effects, indicating overall satisfaction with the medications. However, the study found that tramadol was associated with negative subject-rated effects, suggesting potential for unwanted side effects in some individuals. This research provides valuable insights into the non-analgesic effects of these medications and their potential impact on patient experience.

Navigating the Desert of Opioid Pharmacology

This research delves into the complex world of opioid pharmacology, providing a comprehensive understanding of the non-analgesic effects of tapentadol, tramadol, and hydromorphone. The study highlights the importance of considering these effects in clinical decision-making and patient management. It's like navigating the vast and intricate desert of opioid pharmacology, carefully considering the potential benefits and risks associated with these medications.

Dr.Camel's Conclusion

This study sheds light on the non-analgesic pharmacodynamic effects of tapentadol, tramadol, and hydromorphone, providing valuable insights into their potential impact on patient experience. The findings highlight the importance of carefully considering both the benefits and risks associated with these medications in clinical decision-making. It's like navigating the vast and intricate desert of opioid pharmacology, seeking to understand the full range of effects and ensure safe and effective treatment for patients.

Date :
  1. Date Completed 2014-02-10
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23430163

DOI: Digital Object Identifier

NIHMS448506

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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