著者: Schöller-GyüreMonika, KakudaThomas N, De SmedtGoedele, WoodfallBrian, BerckmansCindy, PeetersMonika, HoetelmansRichard M W

原題: Effects of hepatic impairment on the steady-state pharmacokinetics of etravirine 200 mg BID: an open-label, multiple-dose, controlled Phase I study in adults.

著者: LandrySébastien, ChenChi-Nan, PatelNimish, TsengAlice, LalondeRichard G, ThibeaultDenis, SancheSteven, SheehanNancy L

原題: Therapeutic drug monitoring in treatment-experienced HIV-infected patients receiving darunavir-based salvage regimens: A case series.

著者: KityoCissy, ThompsonJennifer, NankyaImmaculate, HoppeAnne, NdashimyeEmmanuel, WarambwaColin, MambuleIvan, van OosterhoutJoep J, Wools-KaloustianKara, BertagnolioSilvia, EasterbrookPhilippa J, MugyenyiPeter, WalkerA Sarah, PatonNicholas I,

原題: HIV Drug Resistance Mutations in Non-B Subtypes After Prolonged Virological Failure on NNRTI-Based First-Line Regimens in Sub-Saharan Africa.

著者: TianYe, LiuZhaoqiang, LiuJinghan, HuangBoshi, KangDongwei, ZhangHeng, De ClercqErik, DaelemansDirk, PannecouqueChristophe, LeeKuo-Hsiung, ChenChin-Ho, ZhanPeng, LiuXinyong

原題: Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.

著者: JinXin, PiaoHu-Ri, PannecouqueChristophe, De ClercqErik, ZhuangChunlin, ChenFen-Er

原題: Design of the naphthyl-diarylpyrimidines as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) via structure-based extension into the entrance channel.

著者: PicchioGaston R, RimskyLaurence T, Van EygenVeerle, HaddadMojgan, NapolitanoLaura A, VingerhoetsJohan

原題: Prevalence in the USA of rilpivirine resistance-associated mutations in clinical samples and effects on phenotypic susceptibility to rilpivirine and etravirine.

著者: InduPurushothaman, RameshkumarMarimuthu Ragavan, ArunagirinathanNarasingam, Al-DhabiNaif Abdullah, Valan ArasuMariadhas, IgnacimuthuSavarimuthu

原題: Raltegravir, Indinavir, Tipranavir, Dolutegravir, and Etravirine against main protease and RNA-dependent RNA polymerase of SARS-CoV-2: A molecular docking and drug repurposing approach.

著者: ZhaoTong, MengQing, KangDongwei, JiJianbo, De ClercqErik, PannecouqueChristophe, LiuXinyong, ZhanPeng

原題: Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing.

著者: YangYang, PannecouqueChristophe, ClercqErik De, ZhuangChunlin, ChenFen-Er

原題: Privileged scaffold inspired design of novel oxime-biphenyl-DAPYs in treatment of HIV-1.

著者: GodinhoAna L A, MartinsInês L, NunesJoão, CharneiraCatarina, GriloJorge, SilvaDiogo M, PereiraSofia A, SotoKarina, OliveiraM Conceição, MarquesM Matilde, JacobCristina C, AntunesAlexandra M M

原題: High resolution mass spectrometry-based methodologies for identification of Etravirine bioactivation to reactive metabolites: In vitro and in vivo approaches.

著者: SariyerIlker Kudret, GordonJennifer, BurdoTricia H, WolleboHassen S, GiantiEleonora, DonadoniMartina, BellizziAnna, CicaleseStephanie, LoomisRegina, RobinsonJake A, CarnevaleVincenzo, SteinerJoseph, OzdenerMehmet H, MillerAndrew D, AminiShohreh, KleinMichael L, KhaliliKamel

原題: Suppression of Zika Virus Infection in the Brain by the Antiretroviral Drug Rilpivirine.

著者: GuptaSamir K, MiDeming, LiuZiyue, SahaChandan

原題: Endothelial, inflammatory, coagulation, metabolic effects and safety of etravirine in HIV-uninfected volunteers.

著者: Contreras-GalindoRafael, DubeDerek, FujinagaKoh, KaplanMark H, MarkovitzDavid M

原題: Susceptibility of Human Endogenous Retrovirus Type K to Reverse Transcriptase Inhibitors.

著者: ZhouZhongxia, LiuTao, KangDongwei, HuoZhipeng, WuGaochan, DaelemansDirk, De ClercqErik, PannecouqueChristophe, ZhanPeng, LiuXinyong

原題: Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel".

著者: KangDongwei, FangZengjun, HuangBoshi, LuXueyi, ZhangHeng, XuHaoran, HuoZhipeng, ZhouZhongxia, YuZhao, MengQing, WuGaochan, DingXiao, TianYe, DaelemansDirk, De ClercqErik, PannecouqueChristophe, ZhanPeng, LiuXinyong

原題: Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants.

著者: TamaletCatherine, Tissot-DupontHervé, MotteAnne, TourrèsChristian, DhiverCatherine, RavauxIsabelle, Poizot-MartinIsabelle, DiengThérèse, TomeiChristelle, BregigeonSylvie, Zaegel-FaucherOlivia, LarocheHélène, AherfiSarah, MokhtariSaadia, ChaudetHervé, MénardAmelie, BrouquiPhilippe, SteinAndreas, ColsonPhilippe

原題: Emergence of uncommon HIV-1 non-B subtypes and circulating recombinant forms and trends in transmission of antiretroviral drug resistance in patients with primary infection during the 2013-2015 period in Marseille, Southeastern France.

著者: HanSheng, SangYali, WuYan, TaoYuan, PannecouqueChristophe, De ClercqErik, ZhuangChunlin, ChenFen-Er

原題: Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors.

著者: MooreKaty, ThakkarNilay, MageeMindy, SevinskyHeather, VakkalagaddaBlisse, LubinSusan, LlamosoCyril, AckermanPeter

原題: Pharmacokinetics of Temsavir, the Active Moiety of the HIV-1 Attachment Inhibitor Prodrug, Fostemsavir, Coadministered with Cobicistat, Etravirine, Darunavir/Cobicistat, or Darunavir/Ritonavir with or without Etravirine in Healthy Participants.

著者: FrangePierre, Avettand-FenoelVéronique, VeberFlorence, BlancheStéphane, ChaixMarie-Laure

原題: Prevalence of drug resistance in children recently diagnosed with HIV-1 infection in France (2006-17): impact on susceptibility to first-line strategies.

著者: BissioEmiliano, BarbásMaria G, KademiánSilvia, BouzasMaria B, SalomónHoracio, CudoláAnalia, GiulianoSilvina Fernández, FalistoccoCarlos

原題: Prevalence of rilpivirine resistance in people starting antiretroviral treatment in Argentina.

著者: DuwalSulav, DickinsonLaura, KhooSaye, von KleistMax

原題: Mechanistic framework predicts drug-class specific utility of antiretrovirals for HIV prophylaxis.

著者: ShoaibTagyedeen H, IbraheemWalaa, AbdelrahmanMohammed, OsmanWadah, SherifAsmaa E, AshourAhmed, IbrahimSabrin R M, GhazawiKholoud F, MiskiSamar F, AlmadaniSara A, ALsiyudDuaa Fahad, MohamedGamal A, AlzainAbdulrahim A

原題: Exploring the potential of approved drugs for triple-negative breast cancer treatment by targeting casein kinase 2: Insights from computational studies.

著者: CorriganBethany, MukuiIrene, MulengaLloyd, MthethwaNobuhle, LetsieMosilinyane, BrunoStephanie, RakhmaninaNatella

原題: Characteristics of Treatment-experienced HIV-infected African Children and Adolescents Initiating Darunavir and/or Etravirine-based Antiretroviral Treatment.

著者: WangZhao, ZalloumWaleed A, WangWenbo, JiangXiangyi, De ClercqErik, PannecouqueChristophe, KangDongwei, ZhanPeng, LiuXinyong

原題: Discovery of Novel Dihydrothiopyrano[4,3-<i>d</i>]pyrimidine Derivatives as Potent HIV-1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles.

著者: LiJianjian, XuYawen, LiuJiafa, YangBihui, YangCuixian, ZhangMi, DongXingqi

原題: Drug resistance evolution in patients with human immunodeficiency virus-1 under long-term antiretroviral treatment-failure in Yunnan Province, China.

著者: DiphokoThabo, GaseitsiweSimani, KasvosveIshmael, MoyoSikhulile, OkatchHarriet, MusondaRosemary, WainbergMark, MakhemaJoseph, MarlinkRichard, NovitskyVladimir, EssexMax

原題: Prevalence of Rilpivirine and Etravirine Resistance Mutations in HIV-1 Subtype C-Infected Patients Failing Nevirapine or Efavirenz-Based Combination Antiretroviral Therapy in Botswana.