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Increased risk of chronic graft-versus-host disease, obstructive bronchiolitis, and alopecia with busulfan versus total body irradiation: long-term results of a randomized trial in allogeneic marrow recipients with leukemia. Nordic Bone Marrow Transplantation Group.

Author: JacobsenN, LenhoffS, LjungmanP, MellanderL, NikoskelainenJ, ParkkaliT, RembergerM, RingdénO, RuutuT, SallerforsB, VindeløvL, VolinL

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the effects of busulfan and total body irradiation (TBI) as conditioning regimens for bone marrow transplantation in leukemic patients. Busulfan was associated with a higher risk of veno-occlusive disease of the liver, hemorrhagic cystitis, and chronic graft-versus-host disease, while TBI was associated with a higher risk of obstructive bronchiolitis and cataracts.
Paper Details　
Original Abstract of the Article :
Leukemic patients receiving marrow from HLA-identical sibling donors were randomized to treatment with either busulfan 16 mg/kg (n = 88) or total body irradiation ([TBI] n = 79) in addition to cyclophosphamide 120 mg/kg. The patients were observed for a period of 5 to 9 years. Busulfan-treated patie...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/10090927

データ提供：米国国立医学図書館（NLM）

Busulfan vs. Total Body Irradiation: A Bone Marrow Transplant Showdown

This study compared the effects of two different pre-transplant treatments, busulfan and total body irradiation (TBI), on leukemia patients receiving bone marrow transplants. Imagine two desert trails – one is paved with busulfan, the other with TBI – both leading to the same destination (a healthy transplant). This study explores which path has fewer side effects.

Busulfan's Side Effects: A Rough Ride

The study found that busulfan had a higher incidence of some complications like veno-occlusive disease of the liver, hemorrhagic cystitis, and chronic graft-versus-host disease (GVHD). It’s like navigating a desert with unpredictable sandstorms – busulfan can lead to some bumpy terrain. It’s crucial to understand these risks and monitor patients closely.

Finding the Right Path for a Successful Transplant

This research shows that while busulfan and TBI both have their drawbacks, TBI might be a smoother journey for some patients. However, it’s essential to consider the individual patient’s situation, risk factors, and potential benefits. Choosing the right path is like selecting the best camel for your desert adventure – a wise decision can lead to a smooth and successful journey.

Dr. Camel's Conclusion

This study emphasizes the importance of understanding the potential side effects of different pre-transplant treatments. It’s like navigating a desert with a map – knowing the lay of the land can help us make informed decisions for our patients.

Date :
  1. Date Completed 1999-04-19
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

10090927

DOI: Digital Object Identifier

S0006-4971(20)48975-X

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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