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Effects of prophylactic nalmefene on the incidence of morphine-related side effects in patients receiving intravenous patient-controlled analgesia.

Author: ChehadeJ, DuffyL, GajrajN, JohnsonE R, JoshiG P, WesevichJ

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study was designed to determine the dose-response relation for nalmefene for the prevention of morphine-related side effects in patients receiving intravenous patient-controlled analgesia.
Paper Details　
Original Abstract of the Article :
Opioid-related side effects associated with intravenous patient-controlled analgesia can be reduced by a low-dose naloxone infusion. The influence of nalmefene, a pure opioid antagonist with a longer duration of action, on opioid-related side effects has not been evaluated. This study was designed t...See full text at original site
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引用元：
https://doi.org/10.1097/00000542-199904000-00013

データ提供：米国国立医学図書館（NLM）

Nalmefene: A New Oasis in the Desert of Opioid-Related Side Effects

The use of opioids for pain management can sometimes feel like a double-edged sword, offering relief but also carrying the risk of unwanted side effects. This study investigates the potential of nalmefene, a pure opioid antagonist, to prevent morphine-related side effects in patients receiving intravenous patient-controlled analgesia. The researchers, seeking to minimize the negative impacts of opioid therapy, conducted a dose-response study to determine the optimal dose of nalmefene for effectively mitigating side effects.

Navigating the Desert of Opioid Side Effects: Finding the Right Balance

The study explores the potential of nalmefene as a valuable tool for managing opioid-related side effects. By finding the optimal dose of nalmefene, clinicians can potentially minimize the risk of these adverse effects while still providing effective pain relief. It's like finding the right oasis in the desert of opioid therapy, offering a balance between relief and safety.

Finding the Oasis of Relief: Managing Opioid Side Effects Effectively

This research highlights the importance of proactive strategies to manage opioid-related side effects. The findings suggest that nalmefene may offer a promising solution for minimizing these side effects, ensuring a more comfortable and manageable experience for patients receiving opioid therapy. Remember, navigating the desert of pain management requires a careful approach, finding the right oasis to ensure both relief and safety.

Dr.Camel's Conclusion

This study offers valuable insights into the potential of nalmefene for effectively managing opioid-related side effects. It's a reminder that finding the right balance between pain relief and minimizing side effects is crucial in opioid therapy. By carefully navigating the desert of pain management, we can find oases of relief and safety for patients.

Date :
  1. Date Completed 1999-04-21
  2. Date Revised 2019-06-28
Further Info :

Pubmed ID

10201671

DOI: Digital Object Identifier

10.1097/00000542-199904000-00013

SNS
PICO Info
in preparation
Languages

English

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