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A double-blind, placebo-controlled investigation of the effects of fexofenadine, loratadine and promethazine on cognitive and psychomotor function.

Author: FairweatherD B, HindmarchI, ShamsiZ, StanleyN

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Fexofenadine at doses up to 180 mg appears free from disruptive effects on aspects of psychomotor and cognitive function. Loratadine did not cause any significant impairment of cognitive function. Promethazine caused significant impairment of cognitive function and increased sleep-like activity.
Paper Details　
Original Abstract of the Article :
AIMS: To assess whether fexofenadine in a range of doses from 80 to 180 mg has any disruptive effects on aspects of psychomotor and cognitive function in comparison with placebo, loratadine and promethazine, an antihistamine known to produce psychomotor and cognitive impairment. METHODS: Twenty-fou...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2125.1999.00993.x

データ提供：米国国立医学図書館（NLM）

Fexofenadine, Loratadine, and Promethazine: Cognitive and Psychomotor Effects

This study delves into the effects of [antihistamines] on [cognitive and psychomotor function] in a controlled environment, much like observing the subtle shifts in sand dunes during a desert windstorm. The researchers, like astute observers, meticulously record the impact of different antihistamines, hoping to understand their effects on mental alertness and physical coordination. The findings suggest that certain antihistamines may have a greater impact than others, influencing the ability to perform tasks that require focus and agility.

Fexofenadine and Loratadine Show Minimal Cognitive Impact

The study found that [fexofenadine and loratadine had minimal disruptive effects on cognitive and psychomotor function] when compared to [promethazine]. This discovery is like finding a path through a desert that allows for safe and efficient travel, minimizing the chances of getting lost or disoriented.

Potential for Safe and Effective Treatment

The research findings suggest that [fexofenadine and loratadine could be considered safer alternatives to promethazine] for individuals who require antihistamine treatment and need to maintain optimal cognitive function. This is like finding a spring of water in a desert that is both refreshing and safe to drink, offering a more desirable option for those seeking relief.

Dr.Camel's Conclusion

This study provides valuable information about the cognitive and psychomotor effects of different antihistamines. The findings suggest that fexofenadine and loratadine could be safer options for individuals who need antihistamine treatment and want to minimize any potential impact on their mental agility and physical coordination. This research is like a map of the desert of the mind, guiding us towards a more informed and strategic approach to antihistamine treatment.

Date :
  1. Date Completed 1999-09-20
  2. Date Revised 2019-05-13
Further Info :

Pubmed ID

10417497

DOI: Digital Object Identifier

10.1046/j.1365-2125.1999.00993.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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