Effect of varying doses of potassium-magnesium citrate on thiazide-induced hypokalemia and magnesium loss.

Author: GonzalezG, PakC Y, RumlL A, TaylorR, WuermserL A

Paper Details 
Original Abstract of the Article :
The purpose of this study was to compare the efficacy of three dosages of potassium-magnesium citrate in overcoming thiazide-induced hypokalemia and magnesium loss and increasing urinary pH and citrate. Sixty-one normal subjects first took hydrochlorothiazide at 50 mg/d. After 3 weeks of thiazide tr...See full text at original site
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引用元:
https://doi.org/10.1097/00045391-199901000-00007

データ提供:米国国立医学図書館(NLM)

Potassium-Magnesium Citrate: A Balancing Act for Thiazide-Induced Hypokalemia

Thiazide diuretics are commonly used to manage high blood pressure, but they can lead to a depletion of potassium and magnesium in the body. This research investigates the efficacy of potassium-magnesium citrate in overcoming these imbalances. The authors conducted a study involving 61 subjects who were taking hydrochlorothiazide. They then randomized the subjects to receive one of three dosages of potassium-magnesium citrate for three weeks. The study found that all three dosages effectively raised serum potassium levels, with the two higher dosages also leading to an increase in serum magnesium. The researchers also observed a dose-dependent increase in urinary pH and citrate, indicating that potassium-magnesium citrate could help prevent the formation of kidney stones. These findings provide valuable insights into the potential benefits of potassium-magnesium citrate in managing thiazide-induced electrolyte imbalances.

Balancing Act: Potassium-Magnesium Citrate to the Rescue

This research highlights the importance of addressing the electrolyte imbalances that can occur with thiazide diuretic use. The study demonstrates that potassium-magnesium citrate is a safe and effective solution for restoring potassium and magnesium levels. The findings also suggest that this supplement could play a role in preventing kidney stones. This is a valuable piece of information for healthcare professionals and patients alike.

Mind Your Minerals: Staying Balanced

Maintaining a balanced electrolyte balance is vital for our overall health. The research underscores the importance of taking a proactive approach to managing thiazide-induced electrolyte imbalances. If you are taking thiazide diuretics, be sure to discuss your electrolyte levels with your doctor and explore options for maintaining balance.

Dr. Camel's Conclusion

This research serves as a reminder that even seemingly minor fluctuations in our mineral balance can have significant implications for our health. The findings emphasize the importance of monitoring electrolyte levels and, when necessary, taking steps to restore balance. Potassium-magnesium citrate has emerged as a valuable tool in managing thiazide-induced electrolyte imbalances and preventing kidney stones. As we navigate the world of medicine, it is essential to pay attention to the delicate balance of our internal environment, ensuring a healthy and harmonious journey for our bodies.

Date :
  1. Date Completed 1999-12-16
  2. Date Revised 2019-11-03
Further Info :

Pubmed ID

10423646

DOI: Digital Object Identifier

10.1097/00045391-199901000-00007

SNS
PICO Info
in preparation
Languages

English

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