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A randomized, open, parallel-group trial to compare the endocrine effects of oral anastrozole (Arimidex) with intramuscular formestane in postmenopausal women with advanced breast cancer.

Author: CalvoL, ClackG, DodwellD J, DowsettM, KleebergU R, Perez-CarrionR, RobertsonJ F, VorobiofD A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Anastrozole was found to provide more consistent and significantly more effective suppression of oestradiol compared with formestane.
Paper Details　
Original Abstract of the Article :
BACKGROUND: This study provides a direct randomized comparison of a new-generation, non-steroidal aromatase inhibitor, anastrozole (Arimidex), with a steroidal aromatase inhibitor (formestane) with respect to oestrogen (oestradiol, oestrone, and oestrone sulphate) suppression and tolerability. PATI...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/10586340

データ提供：米国国立医学図書館（NLM）

Aromatase Inhibitors: Navigating the Desert of Hormone Suppression

Breast cancer is a challenging disease that often requires careful management, including hormone therapy. This study compares the effectiveness of two aromatase inhibitors, anastrozole and formestane, in postmenopausal women with advanced breast cancer.

Hormone Suppression: A Journey Through the Desert

The study found that anastrozole more effectively suppressed estrogen levels compared to formestane. This is like finding a more effective method of controlling the flow of water in a desert landscape, ensuring that the right amount of resources is available for growth and survival.

Finding the Right Path

The study highlights the importance of selecting the most appropriate aromatase inhibitor for individual patients, based on their specific needs and risk factors. This is like choosing the right path through the desert, selecting a route that leads to the most favorable outcomes for the patient's journey towards health.

Dr. Camel's Conclusion

This study offers valuable insights into the effectiveness of aromatase inhibitors in treating breast cancer. By understanding the nuances of hormone suppression, we can potentially find more effective ways to navigate the desert of disease and create a path towards better outcomes for patients.
Date :
  1. Date Completed 1999-12-22
  2. Date Revised 2020-02-03
Further Info :

Pubmed ID

10586340

DOI: Digital Object Identifier

S0923-7534(19)57385-9

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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