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Hemostatic effects of aprotinin, tranexamic acid and epsilon-aminocaproic acid in primary cardiac surgery.

Author: AlfieriO, CaloriG, CasatiV, CossoliniM, GuzzonD, OppizziM, TorriG

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Tranexamic acid (TA) was found to be as effective as aprotinin (AP) in reducing bleeding and transfusions after elective cardiac surgery, but with significantly lower costs.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The effects of epsilon-aminocaproic acid (EACA) and tranexamic acid (TA) on bleeding and allogeneic transfusions, and the cost of pharmacological and transfusional treatment were compared to aprotinin (AP). METHODS: We randomized 210 patients subjected to elective cardiac surgery. Of th...See full text at original site
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引用元：
https://doi.org/10.1016/s0003-4975(99)00866-8

データ提供：米国国立医学図書館（NLM）

Hemostatic Effects in Cardiac Surgery

This research explores the use of various hemostatic agents in cardiac surgery, a field where minimizing bleeding is crucial for patient safety. It's like navigating a desert landscape, where every drop of blood is precious and requires careful management. This research delves into the effectiveness of different hemostatic agents, comparing their impact on bleeding, transfusion needs, and overall cost effectiveness.

Comparing Hemostatic Agents

The study compares the efficacy of aprotinin, tranexamic acid (TA), and epsilon-aminocaproic acid (EACA) in minimizing blood loss and transfusion requirements. It's like comparing different water sources in the desert, evaluating their efficiency and effectiveness. This study provides valuable insights into the pros and cons of each agent, helping clinicians choose the best option for individual patients.

Balancing Efficacy and Cost

The research highlights the importance of considering not only the effectiveness of hemostatic agents but also their cost-effectiveness. It's like finding a sustainable water source in the desert, ensuring that the benefits outweigh the resources required. This study suggests that TA may offer a cost-effective alternative to aprotinin while achieving similar outcomes in reducing bleeding and transfusion needs.

Dr.Camel's Conclusion

This research is like finding a hidden oasis of knowledge in the desert of cardiac surgery. It provides valuable insights into the effectiveness and cost-effectiveness of different hemostatic agents, guiding clinicians toward the most appropriate treatment choices for their patients. It's a reminder that in the demanding world of surgery, even the smallest details can have a significant impact on patient outcomes.
Date :
  1. Date Completed 2000-01-13
  2. Date Revised 2019-06-28
Further Info :

Pubmed ID

10617012

DOI: Digital Object Identifier

10.1016/s0003-4975(99)00866-8

SNS
PICO Info
in preparation
Languages

English

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