Paper Details

  1. Home
  2. Paper Details

The effects of intrinsic sympathomimetic activity on beta-blocker efficacy for treatment of neurocardiogenic syncope.

Author: BlackM, CayenneS, CohenT J, DoolittleS, IbrahimB, QuanW

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study compared the efficacy and side effects of beta-blockers with intrinsic sympathomimetic activity (ISA) to those without ISA in patients with neurocardiogenic syncope (NCS). Beta-blockers with or without ISA had comparable clinical efficacy in suppressing recurrent syncope in patients with NCS. Beta-blockers with ISA were better tolerated and caused less fatigue (32% side effects) as compared to those without ISA (50% side effects).
Paper Details　
Original Abstract of the Article :
To compare the efficacy and side effects of beta-blockers with intrinsic sympathomimetic activity (ISA) to those without ISA, we retrospectively reviewed patients diagnosed with neurocardiogenic syncope (NCS) as determined by head-up tilt table testing. Four hundred and thirty-one patients (mean age...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/10745573

データ提供：米国国立医学図書館（NLM）

Beta-Blockers for Neurocardiogenic Syncope: A Comparative Study

This study compares the efficacy and side effects of beta-blockers with and without intrinsic sympathomimetic activity (ISA) in patients with neurocardiogenic syncope (NCS). The researchers aim to understand the potential differences in effectiveness and tolerability between these two types of beta-blockers, providing valuable insights for clinical practice. This research provides crucial information for selecting the most appropriate beta-blocker for patients with NCS.

Beta-Blockers with ISA: A Potential Benefit for Younger Patients

The study found that both beta-blockers with and without ISA had comparable efficacy in suppressing recurrent syncope in patients with NCS. However, beta-blockers with ISA were better tolerated, particularly in younger patients, causing less fatigue and fewer side effects. These findings suggest that beta-blockers with ISA might be a preferable option for younger patients with NCS.

Choosing the Right Beta-Blocker for NCS

This study highlights the importance of considering age and individual factors when selecting a beta-blocker for treating NCS. It suggests that while both types of beta-blockers can be effective, beta-blockers with ISA may offer a better balance of efficacy and tolerability for certain patient populations.

Dr. Camel's Conclusion

This study provides valuable guidance on the use of beta-blockers for treating NCS. It reminds us that the vast desert of medicine is filled with variations and nuances, and that choosing the right treatment approach for each individual is key. It also highlights the importance of continued research to optimize treatment strategies and improve patient outcomes.

Date :
  1. Date Completed 2005-04-14
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

10745573

DOI: Digital Object Identifier

10745573

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.