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Optimized therapeutic ratio of inhaled corticosteroids using retrometabolism.

Author: DerendorfH, HochhausG, KrishnaswamiS, MeibohmB, MöllmannH

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study assessed the predictive power of a PK/PD model for predicting the cumulative suppression of endogenous cortisol release (CCS) of inhaled corticosteroids. The presented PK/PD model proved to be a valid tool for predicting CCS of inhaled corticosteroids.
Paper Details　
Original Abstract of the Article :
During recent years, the treatment of pulmonary diseases could be significantly improved due to the introduction of modern retrometabolism-based corticosteroids with improved therapeutic ratio. It is the goal of all inhaled corticosteroids to produce long lasting therapeutic effects at the pulmonary...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/10756545

データ提供：米国国立医学図書館（NLM）

Optimizing Inhaled Corticosteroids: Retrometabolism for Improved Therapeutic Ratio

Inhaled corticosteroids are a mainstay of treatment for pulmonary diseases like asthma and chronic obstructive pulmonary disease (COPD). These medications aim to reduce inflammation in the lungs while minimizing systemic side effects. This study explores the concept of retrometabolism, a process that can enhance the therapeutic ratio of inhaled corticosteroids by optimizing their pharmacokinetic and pharmacodynamic properties.

Retrometabolism: A New Approach to Drug Design

The authors developed a pharmacokinetic/pharmacodynamic (PK/PD) model to predict the effects of different inhaled corticosteroids based on dose. They compared the model’s predictions to clinical trial data for four different corticosteroids, finding a strong correlation. This suggests that retrometabolism can be used to optimize the design of inhaled corticosteroids, leading to improved therapeutic outcomes.

Potential for Improved Treatment of Pulmonary Diseases

This research highlights the potential of retrometabolism for enhancing the therapeutic ratio of inhaled corticosteroids. By optimizing their PK/PD properties, retrometabolism could lead to more effective and safer treatment for pulmonary diseases. Further research is needed to validate these findings and explore the full potential of retrometabolism for improving inhaled corticosteroid therapy.

Dr.Camel's Conclusion

Think of inhaled corticosteroids as a desert oasis providing life-sustaining water for camels suffering from lung ailments. Retrometabolism acts like a skilled oasis manager, optimizing the water flow and ensuring a balanced supply for all. This research highlights the potential of retrometabolism to improve the effectiveness and safety of inhaled corticosteroids, ensuring a healthy oasis for camels in need. It’s like finding a perfectly managed oasis, providing the right amount of water at the right time for optimal well-being.

Date :
  1. Date Completed 2000-05-03
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

10756545

DOI: Digital Object Identifier

10756545

SNS
PICO Info
in preparation
Languages

English

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