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Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.

Author: GrindeE, Herrick-DavisK, TeitlerM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Atypical antipsychotic drugs, such as clozapine, olanzapine, and risperidone, were found to be potent inverse agonists at 5-HT(2C) receptors, while typical antipsychotic drugs were not. This finding suggests that 5-HT(2C) inverse agonist activity may be associated with the unique clinical properties of atypical antipsychotic drugs.
Paper Details　
Original Abstract of the Article :
Clozapine is the prototype atypical antipsychotic drug, producing little or no extrapyramidal side effects, while improving negative symptoms of psychosis. Clozapine's high affinity for serotonin receptors has been hypothesized to confer the unique antipsychotic properties of this drug. Recently, we...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/10991983

データ提供：米国国立医学図書館（NLM）

Atypical Antipsychotic Drugs: Exploring the Role of 5-HT2C Receptor Inverse Agonism

Atypical antipsychotic drugs, such as clozapine, have revolutionized the treatment of schizophrenia, offering improved efficacy with fewer side effects compared to traditional antipsychotics. This research investigates the potential role of 5-HT2C receptor inverse agonism in the unique properties of atypical antipsychotic drugs. The study examined the effects of both typical and atypical antipsychotic drugs on the activity of 5-HT2C receptors in mammalian cells. The researchers discovered that atypical antipsychotics displayed potent inverse agonist activity at 5-HT2C receptors, while typical antipsychotics generally did not.

5-HT2C Receptor Inverse Agonism: A Potential Key to Atypical Antipsychotic Action

The study suggests that inverse agonist activity at 5-HT2C receptors could be a key factor contributing to the unique clinical properties of atypical antipsychotics. This finding provides valuable insight into the mechanisms of action of these drugs and could lead to the development of novel antipsychotic agents with improved efficacy and safety profiles.

Navigating Schizophrenia Treatment: Unlocking the Secrets of the Brain

This research highlights the importance of understanding the complex interplay between neurotransmitters and receptors in the brain in order to develop effective treatments for mental disorders. Exploring the role of 5-HT2C receptor inverse agonism in antipsychotic action opens new avenues for research and potentially offers a new path towards better management of schizophrenia.

Dr. Camel's Conclusion

The desert of mental disorders can be a vast and confusing landscape, filled with challenges for both patients and researchers. This study provides a glimmer of insight into the intricate workings of the brain, exploring the role of 5-HT2C receptor inverse agonism in the unique properties of atypical antipsychotic drugs. Let's continue to delve deeper into the complexities of the brain and discover new ways to alleviate the suffering of those affected by mental illness.

Date :
  1. Date Completed 2000-11-03
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

10991983

DOI: Digital Object Identifier

10991983

SNS
PICO Info
in preparation
Languages

English

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