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An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome.

Author: AbrahamssonH, BjörnssonE S, SimrénM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that lipid infusion lowered the pain threshold in patients with IBS but not in healthy controls. This suggests that postprandial symptoms in IBS patients may be due to a nutrient-dependent exaggerated sensory response in the gastrointestinal tract.
Paper Details　
Original Abstract of the Article :
BACKGROUND/AIMS: Visceral hypersensitivity is a feature of the irritable bowel syndrome (IBS). Postprandial symptoms are common in these patients. The effects of nutrients on colonic perception in IBS are incompletely understood. SUBJECTS: We studied 13 healthy subjects and 16 patients with IBS-eig...See full text at original site
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引用元：
https://doi.org/10.1136/gut.48.1.20

データ提供：米国国立医学図書館（NLM）

Visceral Hypersensitivity in Irritable Bowel Syndrome

This study investigates the role of visceral hypersensitivity in the pathogenesis of irritable bowel syndrome (IBS), focusing on the exaggerated sensory component of the gastrocolonic response in patients with IBS. The researchers examined the colonic perception thresholds to balloon distension and viscerosomatic referral patterns in patients with IBS-D, IBS-C, and healthy controls, before and after duodenal infusion of lipid or saline.

Enhanced Sensory Perception in IBS

The study found that lipid infusion lowered colonic perception thresholds, particularly for gas and pain, in the IBS group, but only for gas in the control group. This suggests that IBS patients exhibit heightened sensory perception of gastrointestinal stimuli, contributing to the characteristic symptoms of IBS. Additionally, IBS patients displayed an increased area of referred discomfort and pain after lipid infusion.

Navigating the Desert of Digestive Discomfort

This research, like a map guiding us through the complexities of digestive disorders, sheds light on the underlying mechanisms of IBS. It underscores the importance of understanding visceral hypersensitivity and its role in driving symptoms. It's a reminder that, just as a desert traveler must be mindful of the terrain, we must be sensitive to the unique challenges faced by individuals with IBS.

Dr.Camel's Conclusion

IBS, like a desert mirage, can be a confusing and frustrating condition. This research, like a compass pointing to a clearer understanding, reveals the crucial role of visceral hypersensitivity. It's a reminder that, just as a desert traveler must adapt to the changing conditions, we must continue to explore the intricacies of IBS to develop more effective treatments and improve the quality of life for those affected by this condition.

Date :
  1. Date Completed 2001-02-22
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

11115818

DOI: Digital Object Identifier

10.1136/gut.48.1.20

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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