Effective treatment of holistic living: A Synthesis of Findings from 32 Studies

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Original Abstract of the Article

Main Research Findings

Irritable bowel syndrome (IBS) is a common condition characterized by abdominal pain and discomfort in the digestive system. Effective treatments are not yet established. Various treatments for IBS have been studied, including probiotics ( 8 )( 11 )( 9 )( 7 )( 12 )( 16 )( 24 )( 22 )( 20 ), acupuncture ( 27 ), hypnotherapy ( 10 ), traditional Chinese medicine ( 6 ), low FODMAP diet ( 29 )( 22 )( 30 ), exercise therapy ( 19 ), yoga ( 21 ), cognitive behavioral therapy ( 18 ), prebiotics ( 13 ), pharmacotherapy ( 3 )( 2 )( 4 )( 25 )( 28 ), melatonin therapy ( 31 ), and electrical stimulation therapy ( 14 ).

IBS symptoms vary from person to person, and the causes are not yet fully understood. Therefore, effective treatments can differ depending on the patient. It is important to try various treatments to find one that works for you.

Benefits and Risks

Benefits Summary

Various approaches have been studied for the treatment of IBS, including probiotics, acupuncture, hypnotherapy, traditional Chinese medicine, low FODMAP diet, exercise therapy, yoga, cognitive behavioral therapy, prebiotics, pharmacotherapy, melatonin therapy, and electrical stimulation therapy. These methods may help to reduce abdominal pain and discomfort in the digestive system.

Risk Summary

Treatment for IBS can involve risks of side effects. Probiotics are generally considered safe, but rare gastrointestinal side effects may occur. Acupuncture should be performed by a qualified professional with proper knowledge and skills. Hypnotherapy may not be effective in some cases, or may even worsen symptoms. Traditional Chinese medicine requires caution regarding the ingredients and side effects of the medication. A low FODMAP diet may lead to a nutritional imbalance. Exercise therapy should be performed within a safe and comfortable range, tailored to your physical condition. Yoga requires attention to your body's flexibility. Cognitive behavioral therapy may take time to show effects. Prebiotics may cause side effects such as gastrointestinal discomfort. Pharmacotherapy has risks of side effects and drug dependence. Melatonin therapy can help improve sleep disorders, but it is important to be aware of side effects. Electrical stimulation therapy may cause side effects such as pain and skin problems.

Comparison Between Studies

Similarities Between Studies

Many studies have suggested that various approaches can improve IBS symptoms.

Differences Between Studies

It is difficult to directly compare research findings as studies differ in terms of the symptoms targeted, treatment methods, and study durations. Also, IBS symptoms vary from person to person, so effective treatments can differ depending on the patient.

Consistency and Contradictions in Results

Research findings on IBS treatment show both consistency and contradictions. While many studies have suggested effectiveness, the effectiveness of specific treatments may not be clear in some cases. Also, effectiveness can vary from patient to patient.

Points to Note Regarding Application in Real Life

IBS treatment should be conducted under the guidance of a healthcare professional. To find the right treatment for your symptoms and body type, it is essential to consult with a doctor or specialist and choose the appropriate treatment. Also, treatment effects can vary from person to person. If you don't see results, don't give up immediately, consult with your doctor or specialist, and continue treatment.

Limitations of Current Research

Research on IBS treatment is still insufficient. Further research is needed, especially regarding long-term effects and the effectiveness of specific treatments. Also, because IBS symptoms vary from person to person, effective treatments can differ depending on the patient. Therefore, more research is needed.

Future Research Directions

To make IBS treatment more effective, research that verifies the effectiveness and safety of specific treatments, investigates long-term effects, and considers optimal treatments tailored to patient constitution and symptoms is needed.

Conclusion

IBS is a common condition for which effective treatments have yet to be established. Various treatment methods are being explored, but their effectiveness can vary from patient to patient. Under the guidance of a doctor or specialist, find the right treatment for you and strive to improve your symptoms.

Keywords
Benefit Keywords
Accelerated gastric emptying
Delayed bowel transit
Improved IBS symptoms
Improved diarrhea symptoms
Less urgency
Reduced diarrhea
Reduced urgency
1
Bowel spasm relaxation
IBS symptom relief
Improved irritable bowel syndrome treatment
2
Improved IBS motility
Improved irritable bowel syndrome treatment
Symptom relief
3
Effective for IBS
IBS symptom relief
Potential for motility control
4
Symptom relief
6
Reduced flatulence
8
IBS symptom relief
Improved IBS treatment
Improved gut health
9
Effective for IBS symptoms
10
Increased stool frequency
Reduced abdominal pain
11
Improved IBS symptoms
Reduced abdominal distension
12
Improved IBS symptoms
13
Improved GI function
Potential for IBS treatment
Treatment of IBS
14
IBS treatment
Improved IBS symptoms
Reduced visceral hypersensitivity
16
Probiotics efficacy
Symptom relief
17
Improved IBS quality of life
Improved bowel symptoms
18
Improved IBS
Improved quality of life
19
Clinical improvement
20
IBS symptom reduction
Improved quality of life
Reduced anxiety
21
Low FODMAP diet for IBS
22
Combined treatment approach
D-IBS treatment
Potential for IBS relief
23
IBS treatment
Improved gut health
Multispecies probiotic
Potential for IBS-D relief
24
Enhanced quality of life
IBS treatment
Improved IBS symptoms
MegaSporeBiotic
Potential for gut microbiota modulation
25
Improved quality of life
Reduced IBS symptoms
26
Acupuncture for IBS
27
IBS treatment
Potential for IBS symptom relief
28
IBS symptom reduction
29
IBS symptom relief
IBS treatment
30
IBS symptom relief
IBS treatment
Improved quality of life
Potential sleep improvement
31
IBS symptom management
Improved well-being
32
Risk Keywords
Accelerated gastric emptying
Delayed bowel transit
1
Mechanism unknown
Unclear efficacy in short-term
Unclear efficacy on colonic transit time
Unclear short-term efficacy
4
IBS
5
Placebo effect
7
Retarded colonic transit
8
Contradictory evidence
Irritable bowel syndrome
Needs further research
9
None specified
13
Limited evidence for IBS
Needs further research
Potential for side effects
14
Dairy intolerance in D-IBS
Lactase deficiency
Lactase deficiency in IBS
Needs further research
15
Modest effects
Needs further research
Potential for side effects
16
None reported
20
Microbiota changes
22
Needs further research
Potential for interactions
Unclear synergistic effects
23
Needs further research
Unclear mechanism
24
Limited comparison
Needs further research
Potential side effects
25
Needs further research
Unclear effects of opioid modulators
28
Dietary restrictions
Needs further research
Unclear predictors
30
Further research needed
Limited study findings
31
Further research needed
No specific findings
32
Literature analysis of 32 papers
Positive Content
29
Neutral Content
0
Negative Content
3
Article Type
26
3
4
5
32
1.

Role of loperamide and placebo in management of irritable bowel syndrome (IBS).

Author: CannP A, ReadN W, HoldsworthC D, BarendsD

Accelerated gastric emptying
Delayed bowel transit
Improved IBS symptoms
Improved diarrhea symptoms
Less urgency
Reduced diarrhea
Reduced urgency
Accelerated gastric emptying
Delayed bowel transit

A study of 28 patients with irritable bowel syndrome found that loperamide was more effective than placebo in relieving symptoms, accelerating gastric emptying, and delaying intestinal transit.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

A double-blind placebo-controlled trial with loperamide in irritable bowel syndrome.

Author: EfskindP S, BernklevT, VatnM H

Bowel spasm relaxation
IBS symptom relief
Improved irritable bowel syndrome treatment

This study investigated the effects of loperamide on irritable bowel syndrome (IBS) symptoms. Previous studies showed that loperamide can relax spasms in the large intestine and improve symptoms of diarrhea. This study aimed to examine the effects of loperamide in a diverse group of people with IBS, acknowledging that IBS symptoms can be caused by different factors affecting bowel movement.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Effects of cisapride on symptoms and postcibal small-bowel motor function in patients with irritable bowel syndrome.

Author: NoorN, SmallP K, LoudonM A, HauC, CampbellF C

Improved IBS motility
Improved irritable bowel syndrome treatment
Symptom relief

This study investigated the effects of long-term treatment with cisapride, a medication that speeds up digestion, on bowel movement and symptoms in patients with irritable bowel syndrome (IBS). The study focused on how cisapride affected the movement of the jejunum (a part of the small intestine) after eating.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Effect of a calcium channel blocker and antispasmodic in diarrhoea-predominant irritable bowel syndrome.

Author: LuC L, ChenC Y, ChangF Y, ChangS S, KangL J, LuR H, LeeS D

Effective for IBS
IBS symptom relief
Potential for motility control
Mechanism unknown
Unclear efficacy in short-term
Unclear efficacy on colonic transit time
Unclear short-term efficacy

Irritable bowel syndrome (IBS) is a disorder affecting the colon. Pinaverlum bromide and mebeverine are medications that have been shown to be effective in treating IBS for a longer period of time (12-16 weeks). This study investigates the effectiveness of these medications for short-term treatment of IBS and their impact on bowel movement speed. The study will also explore if these medications work by influencing specific chemicals in the gut (substance P and neuropeptide Y) that affect bowel movement.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome.

Author: SimrénM, AbrahamssonH, BjörnssonE S

IBS

This study found that lipid infusion lowered the pain threshold in patients with IBS but not in healthy controls. This suggests that postprandial symptoms in IBS patients may be due to a nutrient-dependent exaggerated sensory response in the gastrointestinal tract.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Effect of modified Sinisan on anorectal manometry of the constipation predominant type of irritable bowel syndrome.

Author: YuSu-ping, YeHui, HaNan-lin, DingShu-qing, ChenGao

Symptom relief

Sinisan (SNS) was effective in treating irritable bowel syndrome with constipation. It significantly improved symptom scoring, rectal threshold feeling, and maximal tolerance volume of the rectum.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

The efficacy of Lactobacillus reuteri ATCC 55730 in the treatment of patients with irritable bowel syndrome--a double blind, placebo-controlled, randomized study.

Author: NivEva, NaftaliTimna, HallakRon, VaismanNachum

Placebo effect

IBS symptoms did not improve with probiotic treatment with L. reuteri.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating.

Author: KimH J, Vazquez RoqueM I, CamilleriM, StephensD, BurtonD D, BaxterK, ThomfordeG, ZinsmeisterA R

Reduced flatulence
Retarded colonic transit

VSL#3 reduced flatulence scores and retarded colonic transit without altering bowel function in patients with irritable bowel syndrome (IBS) and bloating.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

9.

[The effects of probiotics on symptoms of irritable bowel syndrome].

Author: KimYoung Gyun, MoonJong Tae, LeeKuen Man, ChonNu Ri, ParkHyojin

IBS symptom relief
Improved IBS treatment
Improved gut health
Contradictory evidence
Irritable bowel syndrome
Needs further research

Irritable bowel syndrome (IBS) is a common digestive disorder with various symptoms, including abdominal pain, diarrhea, constipation, and bloating. While probiotics are thought to potentially improve IBS symptoms by affecting gut function, research results on probiotics for IBS are mixed. This study aimed to investigate the effects of probiotics on digestive symptoms and intestinal gas volume in people with IBS.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Korean

10.

Hypnotherapy for treatment of irritable bowel syndrome.

Author: WebbA N, KukuruzovicR H, Catto-SmithA G, SawyerS M

Effective for IBS symptoms

This review found that the quality of the included trials was inadequate to allow any conclusion about the efficacy of hypnotherapy for irritable bowel syndrome. More research with high quality trials is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

A double blind randomized controlled trial of a probiotic combination in 100 patients with irritable bowel syndrome.

Author: Drouault-HolowaczS, BieuveletS, BurckelA, CazaubielM, DrayX, MarteauP

Increased stool frequency
Reduced abdominal pain

A probiotic combination was not significantly superior to placebo in relieving symptoms of irritable bowel syndrome (IBS). However, the decrease in abdominal pain was significantly higher in probiotic-treated patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation.

Author: AgrawalA, HoughtonL A, MorrisJ, ReillyB, GuyonnetD, Goupil FeuilleratN, SchlumbergerA, JakobS, WhorwellP J

Improved IBS symptoms
Reduced abdominal distension

A probiotic containing Bifidobacterium lactis DN-173 010 reduced abdominal distension, accelerated gastrointestinal transit, and improved symptoms in patients with irritable bowel syndrome (IBS) with constipation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Clinical trial: the effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome.

Author: SilkD B A, DavisA, VulevicJ, TzortzisG, GibsonG R

Improved IBS symptoms
None specified

A galactooligosaccharide prebiotic increased gut bifidobacteria and improved symptoms in patients with irritable bowel syndrome (IBS).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Clinical trial: transcutaneous interferential electrical stimulation in individuals with irritable bowel syndrome - a prospective double-blind randomized study.

Author: CobanŞahin, AkbalErdem, KöklüSeyfettin, KöklüGülşah, UlaşlıMurat Alper, ErkeçSerap, AktaşBora, YükselOsman, KoçakErdem, ErdemHatice Rana

Improved GI function
Potential for IBS treatment
Treatment of IBS
Limited evidence for IBS
Needs further research
Potential for side effects

The cause of irritable bowel syndrome (IBS) is not fully understood, and there's no cure. Treatment focuses on managing symptoms. Some studies suggest that applying electrical stimulation to the skin (transcutaneous electrical stimulation) may be helpful for constipation, delayed stomach emptying, and indigestion.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Prevalence and presentation of lactose intolerance and effects on dairy product intake in healthy subjects and patients with irritable bowel syndrome.

Author: YangJianfeng, DengYanyong, ChuHua, CongYanqun, ZhaoJianmin, PohlDaniel, MisselwitzBenjamin, FriedMichael, DaiNing, FoxMark

Dairy intolerance in D-IBS
Lactase deficiency
Lactase deficiency in IBS
Needs further research

This study examines the relationship between lactose intolerance and digestive symptoms, as well as dairy consumption, in individuals with diarrhea-predominant irritable bowel syndrome (D-IBS) compared to healthy volunteers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Randomized clinical trial on the effect of a multispecies probiotic on visceroperception in hypersensitive IBS patients.

Author: LudidiS, JonkersD M, KoningC J, KruimelJ W, MulderL, van der VaartI B, ConchilloJ M, MascleeA A M

IBS treatment
Improved IBS symptoms
Reduced visceral hypersensitivity
Modest effects
Needs further research
Potential for side effects

This study investigates the effect of a multispecies probiotic on pain sensitivity in people with irritable bowel syndrome (IBS), a condition with varying causes and limited treatment options. The study focuses on those with increased sensitivity in the bowels, which is often linked to more severe symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Therapeutic effects, tolerability and safety of a multi-strain probiotic in Iranian adults with irritable bowel syndrome and bloating.

Author: JafariElham, VahediHomayoon, MeratShahin, MomtahenShabnam, RiahiAina

Probiotics efficacy
Symptom relief

A 4-week period of treatment with a combination of probiotics twice daily was safe, well tolerated, and effective in Iranian adults with irritable bowel syndrome (IBS) with abdominal bloating. The probiotic group reported satisfactory relief of general symptoms in 85% of patients compared with 47% in the control group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

The effects of cognitive behavioral therapy in female nursing students with irritable bowel syndrome: a randomized trial.

Author: JangAe Lee, HwangSun-Kyung, KimDong Uk

Improved IBS quality of life
Improved bowel symptoms

Cognitive behavioral therapy (CBT) was effective in improving clinical states of irritable bowel syndrome (IBS) in young female nursing students.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Intervention to increase physical activity in irritable bowel syndrome shows long-term positive effects.

Author: JohannessonElisabet, RingströmGisela, AbrahamssonHasse, SadikRiadh

Improved IBS
Improved quality of life

This study found that an intervention to increase physical activity in patients with irritable bowel syndrome (IBS) had positive long-term effects on IBS symptoms and psychological symptoms. The participants reported improved IBS symptoms, quality of life, fatigue, depression, and anxiety after 5.2 years of follow-up. The reported time of physical activity during the week before the visit had increased from 3.2 h at baseline to 5.2 h at follow-up.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Therapeutic effects of Lactobacillus in treating irritable bowel syndrome: a meta-analysis.

Author: TiequnBian, GuanqunChao, ShuoZhang

Clinical improvement
None reported

This meta-analysis systematically evaluated the effect of Lactobacillus in treating irritable bowel syndrome (IBS). Six randomized, placebo-controlled trials showed a significantly higher rate of treatment responders with Lactobacillus compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

21.

Effect of Yoga in the Therapy of Irritable Bowel Syndrome: A Systematic Review.

Author: SchumannDania, AnheyerDennis, LaucheRomy, DobosGustav, LanghorstJost, CramerHolger

IBS symptom reduction
Improved quality of life
Reduced anxiety

Yoga might be a feasible and safe adjunctive treatment for irritable bowel syndrome, with significant reductions in bowel symptoms, IBS severity, and anxiety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

A Diet Low in FODMAPs Reduces Symptoms in Patients With Irritable Bowel Syndrome and A Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial.

Author: StaudacherHeidi Maria, LomerMiranda C E, FarquharsonFreda M, LouisPetra, FavaFrancesca, FranciosiElena, ScholzMatthias, TuohyKieran M, LindsayJames O, IrvingPeter M, WhelanKevin

Low FODMAP diet for IBS
Microbiota changes

A low FODMAP diet associates with adequate symptom relief and significantly reduced symptom scores compared with placebo in patients with irritable bowel syndrome (IBS). Co-administration of a multistrain probiotic increased numbers of Bifidobacterium species, compared with placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

The effect of a multispecies probiotic on microbiota composition in a clinical trial of patients with diarrhea-predominant irritable bowel syndrome.

Author: HodKeren, DekelRoy, Aviv CohenNathaniel, SperberAmi, RonYishai, BoazMona, BerlinerShlomo, MaharshakNitsan

IBS treatment
Improved gut health
Multispecies probiotic
Potential for IBS-D relief
Needs further research
Unclear mechanism

This study investigates how a multi-strain probiotic affects gut bacteria in women with diarrhea-predominant irritable bowel syndrome (IBS-D). The study aims to determine if changes in gut bacteria are linked to improvements in IBS symptoms or markers of inflammation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Vortioxetine effects on quality of life of irritable bowel syndrome patients: A randomized, double-blind, placebo-controlled trial.

Author: SeddighniaAzadeh, Tadayon NajafabadiBorna, GhamariKiandokht, NoorbalaAhmad Ali, Ebrahimi DaryaniNaser, KashaniLadan, AkhondzadehShahin

Improved quality of life
Reduced IBS symptoms

Vortioxetine was superior to placebo in increasing quality of life in patients with irritable bowel syndrome (IBS).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

Comparison between the Effects of Acupuncture Relative to Other Controls on Irritable Bowel Syndrome: A Meta-Analysis.

Author: ZhengHaizhen, ChenRixin, ZhaoXiaofeng, LiGuanhui, LiangYi, ZhangHao, ChiZhenhai

Acupuncture for IBS

Acupuncture showed no superiority over sham acupuncture for treating irritable bowel syndrome (IBS), but it had a significant advantage over western medicine. The meta-analysis included 41 randomized controlled trials (RCTs) with 3440 participants. Future high-quality and large-sample-size studies are needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

28.

Efficacy of opioid receptor modulators in patients with irritable bowel syndrome: A systematic review and meta-analysis.

Author: LiXia, LiBo, ZhangJiaqi, ChenTing, WuHaomeng, ShiXiaoshuang, MaJinxin, QinJinyan, TangXudong, WangFengyun

IBS treatment
Potential for IBS symptom relief
Needs further research
Unclear effects of opioid modulators

This study aims to determine whether medications that affect opioid receptors in the body can help improve symptoms of irritable bowel syndrome (IBS). IBS is a common digestive disorder that can significantly impact people's lives, and this study seeks to find potential treatments by examining the role of opioid receptors in gut function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Randomised controlled trial: effects of gluten-free diet on symptoms and the gut microenvironment in irritable bowel syndrome.

Author: AlgeraJoost P, MagnussonMaria K, ÖhmanLena, StörsrudStine, SimrénMagnus, TörnblomHans

IBS symptom reduction

This study investigated the effects of a gluten-free diet in patients with irritable bowel syndrome (IBS). The gluten-free diet improved IBS symptoms, particularly bowel habits, in some patients. The study also identified distinct metabolite profiles in patients who responded to the gluten-free diet, suggesting that the diet influences the gut microbiome.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Low FODMAP diet reduces gastrointestinal symptoms in irritable bowel syndrome and clinical response could be predicted by symptom severity: A randomized crossover trial.

Author: AlgeraJoost P, DemirDagsu, TörnblomHans, NybackaSanna, SimrénMagnus, StörsrudStine

IBS symptom relief
IBS treatment
Dietary restrictions
Needs further research
Unclear predictors

A low FODMAP diet reduced gastrointestinal symptoms and improved bowel habits in IBS patients compared to a moderate FODMAP diet. However, the low FODMAP diet was not effective for everyone. While the study did not identify specific predictors of response to the low FODMAP diet, it suggests that individual sensitivity to FODMAPs varies widely.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

The effect of melatonin on irritable bowel syndrome patients with and without sleep disorders: a randomized double-blinded placebo-controlled trial study.

Author: Faghih DinevariMasood, JafarzadehFarzaneh, Jabbaripour SarmadianAmirreza, AbbasianSamaneh, NikniazZeinab, RiaziAli

IBS symptom relief
IBS treatment
Improved quality of life
Potential sleep improvement
Further research needed
Limited study findings

IBS is a common digestive problem with limited treatment options. This study examines the potential benefits of melatonin, a hormone that regulates sleep, for IBS patients. The study looks at how melatonin impacts IBS symptoms, quality of life, and sleep patterns in both those with and without sleep disorders.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

32.

The Effect of Polyphenols, Minerals, Fibers, and Fruits on Irritable Bowel Syndrome: A Systematic Review.

Author: ChiarioniGiuseppe, PopaStefan Lucian, IsmaielAbdulrahman, PopCristina, DumitrascuDinu Iuliu, BrataVlad Dumitru, DuseTraian Adrian, InczeVictor, Surdea-BlagaTeodora

IBS symptom management
Improved well-being
Further research needed
No specific findings

Irritable bowel syndrome (IBS) is a common digestive disorder. This review examines how different types of foods, including polyphenols (found in fruits, vegetables, and tea), minerals, fiber, and whole fruits, might affect IBS symptoms and overall health.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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