Effective treatment of home remedies: A Synthesis of Findings from 32 Studies

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Original Abstract of the Article

Major research findings

Several treatments and diets have been suggested to potentially alleviate symptoms of irritable bowel syndrome (IBS) based on various studies. 27 Meta-analysis suggested that acupuncture may be effective for IBS symptoms. 9 A study indicated that probiotics could improve IBS symptoms. Moreover, 11 and 16 studies suggested that specific probiotics can have effects in reducing symptoms, particularly bloating, in IBS patients. 29 This study stated that a gluten-free diet may reduce symptoms in some patients with IBS. 22 Research revealed that a low-FODMAP diet could reduce IBS symptoms, and probiotics could restore Bifidobacterium species. 32 A review indicated that polyphenols, minerals, fibers, and fruits may affect IBS symptoms. 17 This study suggested that probiotics could alleviate complaints of patients with minimal side effects. 2 The study showed that loperamide had effects in reducing IBS symptoms. 21 A review suggested that yoga could alleviate IBS symptoms and improve the quality of life. 12 Research showed that fermented milk products containing Bifidobacterium lactis DN-173 010 might reduce abdominal distension and gastrointestinal transit in IBS with constipation, particularly bloating. 4 The study suggested that calcium channel blockers and antispasmodics could be effective for treating diarrhea-predominant IBS. 25 The study indicated that Bacillus spp. spores could improve symptoms in IBS patients. 31 This study showed that melatonin might have therapeutic effects in reducing IBS scores, gastrointestinal symptoms, improving quality of life, and sleep parameters in both groups of IBS patients with and without sleep disorders. 6 Research revealed that Sinisan, a traditional Chinese medicine, could have effects in improving constipation-predominant IBS symptoms. 20 A meta-analysis suggested that Lactobacillus could be effective for treating IBS. 15 The study indicated that lactose intolerance could impact digestive symptoms in IBS patients. 23 This study indicated that herbal extract granules combined with otilonium bromide could be effective for treating diarrhea-predominant IBS. 30 The study demonstrated that a low-FODMAP diet could reduce gastrointestinal symptoms in IBS, and clinical response could be predicted by symptom severity. 19 The study revealed that interventions to increase physical activity in IBS have long-term positive effects. 13 This study showed that trans-galactooligosaccharide prebiotics could potentially improve fecal microbiota and symptoms in IBS. 1 The study indicated that loperamide could reduce IBS symptoms. 26 Research indicated that vortioxetine could improve the quality of life in IBS patients. 28 A meta-analysis suggested that opioid receptor modulators could improve IBS symptoms. 24 Research showed that a multispecies probiotic could impact the microbiota composition in patients with diarrhea-predominant IBS. 18 The study showed that cognitive behavioral therapy could be effective in treating IBS in young women under stressful conditions.

Benefits and Risks

Benefits Summary

There are many treatments and diets that could potentially reduce IBS symptoms. These treatments include acupuncture, specific probiotics, gluten-free diets, low-FODMAP diets, yoga, calcium channel blockers, antispasmodics, Bacillus spp. spores, melatonin, traditional Chinese medicine, increasing physical activity, and cognitive behavioral therapy. These treatments could improve symptoms such as abdominal pain, bloating, constipation, and diarrhea.

Risk Summary

Some treatments carry the risk of side effects. For example, probiotics could cause digestive discomfort. Also, a gluten-free diet could lead to nutritional deficiencies. Traditional Chinese medicine could interact with other medications.

Comparison between Studies

Commonalities of Studies

Many studies suggest that specific treatments and diets could potentially alleviate IBS symptoms. These studies have revealed potential benefits in IBS treatment, including acupuncture, specific probiotics, gluten-free diets, low-FODMAP diets, yoga, calcium channel blockers, antispasmodics, Bacillus spp. spores, melatonin, traditional Chinese medicine, improving physical activity, and cognitive behavioral therapy.

Differences of Studies

Effective treatments and diets may vary depending on the study. Also, some studies may have conflicting results regarding the effectiveness of specific treatments. For example, while some studies suggest that probiotics improve IBS symptoms, other studies have not found any effects.

Consistency and Contradictions in Results

Many studies have suggested specific treatments and diets that could potentially alleviate IBS symptoms; however, some studies have contradicting results. For example, studies on the effectiveness of probiotics and gluten-free diets have reported varying outcomes. These contradictions may be due to variations in study designs, participant characteristics, or other factors.

Application to Daily Life and Notes

Although there are many treatments and diets that could potentially reduce IBS symptoms, these treatments may not be effective for everyone. These treatments also come with the risk of side effects. Therefore, it is crucial to consult a doctor before starting any IBS treatment. Your doctor can suggest the appropriate treatment based on your symptoms and health condition.

Limitations of Current Research

There are several limitations to current research. For example, some studies are small, with a limited number of participants. Some studies may be limited to specific types of IBS patients. These limitations could affect the generalizability of the study results.

Future Research Directions

Future research should conduct larger, more comprehensive studies on treatments for IBS. Research is also needed to investigate the effectiveness of different treatments and diets for specific types of IBS patients.

Conclusion

Many studies suggest that specific treatments and diets could potentially alleviate IBS symptoms. These treatments include acupuncture, specific probiotics, gluten-free diets, low-FODMAP diets, yoga, calcium channel blockers, antispasmodics, Bacillus spp. spores, melatonin, traditional Chinese medicine, improving physical activity, and cognitive behavioral therapy. However, these treatments may not be effective for everyone. Also, these treatments carry the risk of side effects. Therefore, it is important to consult a doctor before starting any IBS treatment.

Keywords
Benefit Keywords
Accelerated gastric emptying
Delayed bowel transit
Improved IBS symptoms
Improved diarrhea symptoms
Less urgency
Reduced diarrhea
Reduced urgency
1
Bowel spasm relaxation
IBS symptom relief
Improved irritable bowel syndrome treatment
2
Improved IBS motility
Improved irritable bowel syndrome treatment
Symptom relief
3
Effective for IBS
IBS symptom relief
Potential for motility control
4
Symptom relief
6
Reduced flatulence
8
IBS symptom relief
Improved IBS treatment
Improved gut health
9
Effective for IBS symptoms
10
Increased stool frequency
Reduced abdominal pain
11
Improved IBS symptoms
Reduced abdominal distension
12
Improved IBS symptoms
13
Improved GI function
Potential for IBS treatment
Treatment of IBS
14
IBS treatment
Improved IBS symptoms
Reduced visceral hypersensitivity
16
Probiotics efficacy
Symptom relief
17
Improved IBS quality of life
Improved bowel symptoms
18
Improved IBS
Improved quality of life
19
Clinical improvement
20
IBS symptom reduction
Improved quality of life
Reduced anxiety
21
Low FODMAP diet for IBS
22
Combined treatment approach
D-IBS treatment
Potential for IBS relief
23
IBS treatment
Improved gut health
Multispecies probiotic
Potential for IBS-D relief
24
Enhanced quality of life
IBS treatment
Improved IBS symptoms
MegaSporeBiotic
Potential for gut microbiota modulation
25
Improved quality of life
Reduced IBS symptoms
26
Acupuncture for IBS
27
IBS treatment
Potential for IBS symptom relief
28
IBS symptom reduction
29
IBS symptom relief
IBS treatment
30
IBS symptom relief
IBS treatment
Improved quality of life
Potential sleep improvement
31
IBS symptom management
Improved well-being
32
Risk Keywords
Accelerated gastric emptying
Delayed bowel transit
1
Mechanism unknown
Unclear efficacy in short-term
Unclear efficacy on colonic transit time
Unclear short-term efficacy
4
IBS
5
Placebo effect
7
Retarded colonic transit
8
Contradictory evidence
Irritable bowel syndrome
Needs further research
9
None specified
13
Limited evidence for IBS
Needs further research
Potential for side effects
14
Dairy intolerance in D-IBS
Lactase deficiency
Lactase deficiency in IBS
Needs further research
15
Modest effects
Needs further research
Potential for side effects
16
None reported
20
Microbiota changes
22
Needs further research
Potential for interactions
Unclear synergistic effects
23
Needs further research
Unclear mechanism
24
Limited comparison
Needs further research
Potential side effects
25
Needs further research
Unclear effects of opioid modulators
28
Dietary restrictions
Needs further research
Unclear predictors
30
Further research needed
Limited study findings
31
Further research needed
No specific findings
32
Literature analysis of 32 papers
Positive Content
29
Neutral Content
0
Negative Content
3
Article Type
26
3
4
5
32
1.

Role of loperamide and placebo in management of irritable bowel syndrome (IBS).

Author: CannP A, ReadN W, HoldsworthC D, BarendsD

Accelerated gastric emptying
Delayed bowel transit
Improved IBS symptoms
Improved diarrhea symptoms
Less urgency
Reduced diarrhea
Reduced urgency
Accelerated gastric emptying
Delayed bowel transit

A study of 28 patients with irritable bowel syndrome found that loperamide was more effective than placebo in relieving symptoms, accelerating gastric emptying, and delaying intestinal transit.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

A double-blind placebo-controlled trial with loperamide in irritable bowel syndrome.

Author: EfskindP S, BernklevT, VatnM H

Bowel spasm relaxation
IBS symptom relief
Improved irritable bowel syndrome treatment

This study investigated the effects of loperamide on irritable bowel syndrome (IBS) symptoms. Previous studies showed that loperamide can relax spasms in the large intestine and improve symptoms of diarrhea. This study aimed to examine the effects of loperamide in a diverse group of people with IBS, acknowledging that IBS symptoms can be caused by different factors affecting bowel movement.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Effects of cisapride on symptoms and postcibal small-bowel motor function in patients with irritable bowel syndrome.

Author: NoorN, SmallP K, LoudonM A, HauC, CampbellF C

Improved IBS motility
Improved irritable bowel syndrome treatment
Symptom relief

This study investigated the effects of long-term treatment with cisapride, a medication that speeds up digestion, on bowel movement and symptoms in patients with irritable bowel syndrome (IBS). The study focused on how cisapride affected the movement of the jejunum (a part of the small intestine) after eating.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Effect of a calcium channel blocker and antispasmodic in diarrhoea-predominant irritable bowel syndrome.

Author: LuC L, ChenC Y, ChangF Y, ChangS S, KangL J, LuR H, LeeS D

Effective for IBS
IBS symptom relief
Potential for motility control
Mechanism unknown
Unclear efficacy in short-term
Unclear efficacy on colonic transit time
Unclear short-term efficacy

Irritable bowel syndrome (IBS) is a disorder affecting the colon. Pinaverlum bromide and mebeverine are medications that have been shown to be effective in treating IBS for a longer period of time (12-16 weeks). This study investigates the effectiveness of these medications for short-term treatment of IBS and their impact on bowel movement speed. The study will also explore if these medications work by influencing specific chemicals in the gut (substance P and neuropeptide Y) that affect bowel movement.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome.

Author: SimrénM, AbrahamssonH, BjörnssonE S

IBS

This study found that lipid infusion lowered the pain threshold in patients with IBS but not in healthy controls. This suggests that postprandial symptoms in IBS patients may be due to a nutrient-dependent exaggerated sensory response in the gastrointestinal tract.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Effect of modified Sinisan on anorectal manometry of the constipation predominant type of irritable bowel syndrome.

Author: YuSu-ping, YeHui, HaNan-lin, DingShu-qing, ChenGao

Symptom relief

Sinisan (SNS) was effective in treating irritable bowel syndrome with constipation. It significantly improved symptom scoring, rectal threshold feeling, and maximal tolerance volume of the rectum.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

The efficacy of Lactobacillus reuteri ATCC 55730 in the treatment of patients with irritable bowel syndrome--a double blind, placebo-controlled, randomized study.

Author: NivEva, NaftaliTimna, HallakRon, VaismanNachum

Placebo effect

IBS symptoms did not improve with probiotic treatment with L. reuteri.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating.

Author: KimH J, Vazquez RoqueM I, CamilleriM, StephensD, BurtonD D, BaxterK, ThomfordeG, ZinsmeisterA R

Reduced flatulence
Retarded colonic transit

VSL#3 reduced flatulence scores and retarded colonic transit without altering bowel function in patients with irritable bowel syndrome (IBS) and bloating.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

9.

[The effects of probiotics on symptoms of irritable bowel syndrome].

Author: KimYoung Gyun, MoonJong Tae, LeeKuen Man, ChonNu Ri, ParkHyojin

IBS symptom relief
Improved IBS treatment
Improved gut health
Contradictory evidence
Irritable bowel syndrome
Needs further research

Irritable bowel syndrome (IBS) is a common digestive disorder with various symptoms, including abdominal pain, diarrhea, constipation, and bloating. While probiotics are thought to potentially improve IBS symptoms by affecting gut function, research results on probiotics for IBS are mixed. This study aimed to investigate the effects of probiotics on digestive symptoms and intestinal gas volume in people with IBS.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Korean

10.

Hypnotherapy for treatment of irritable bowel syndrome.

Author: WebbA N, KukuruzovicR H, Catto-SmithA G, SawyerS M

Effective for IBS symptoms

This review found that the quality of the included trials was inadequate to allow any conclusion about the efficacy of hypnotherapy for irritable bowel syndrome. More research with high quality trials is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

A double blind randomized controlled trial of a probiotic combination in 100 patients with irritable bowel syndrome.

Author: Drouault-HolowaczS, BieuveletS, BurckelA, CazaubielM, DrayX, MarteauP

Increased stool frequency
Reduced abdominal pain

A probiotic combination was not significantly superior to placebo in relieving symptoms of irritable bowel syndrome (IBS). However, the decrease in abdominal pain was significantly higher in probiotic-treated patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation.

Author: AgrawalA, HoughtonL A, MorrisJ, ReillyB, GuyonnetD, Goupil FeuilleratN, SchlumbergerA, JakobS, WhorwellP J

Improved IBS symptoms
Reduced abdominal distension

A probiotic containing Bifidobacterium lactis DN-173 010 reduced abdominal distension, accelerated gastrointestinal transit, and improved symptoms in patients with irritable bowel syndrome (IBS) with constipation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Clinical trial: the effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome.

Author: SilkD B A, DavisA, VulevicJ, TzortzisG, GibsonG R

Improved IBS symptoms
None specified

A galactooligosaccharide prebiotic increased gut bifidobacteria and improved symptoms in patients with irritable bowel syndrome (IBS).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Clinical trial: transcutaneous interferential electrical stimulation in individuals with irritable bowel syndrome - a prospective double-blind randomized study.

Author: CobanŞahin, AkbalErdem, KöklüSeyfettin, KöklüGülşah, UlaşlıMurat Alper, ErkeçSerap, AktaşBora, YükselOsman, KoçakErdem, ErdemHatice Rana

Improved GI function
Potential for IBS treatment
Treatment of IBS
Limited evidence for IBS
Needs further research
Potential for side effects

The cause of irritable bowel syndrome (IBS) is not fully understood, and there's no cure. Treatment focuses on managing symptoms. Some studies suggest that applying electrical stimulation to the skin (transcutaneous electrical stimulation) may be helpful for constipation, delayed stomach emptying, and indigestion.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Prevalence and presentation of lactose intolerance and effects on dairy product intake in healthy subjects and patients with irritable bowel syndrome.

Author: YangJianfeng, DengYanyong, ChuHua, CongYanqun, ZhaoJianmin, PohlDaniel, MisselwitzBenjamin, FriedMichael, DaiNing, FoxMark

Dairy intolerance in D-IBS
Lactase deficiency
Lactase deficiency in IBS
Needs further research

This study examines the relationship between lactose intolerance and digestive symptoms, as well as dairy consumption, in individuals with diarrhea-predominant irritable bowel syndrome (D-IBS) compared to healthy volunteers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Randomized clinical trial on the effect of a multispecies probiotic on visceroperception in hypersensitive IBS patients.

Author: LudidiS, JonkersD M, KoningC J, KruimelJ W, MulderL, van der VaartI B, ConchilloJ M, MascleeA A M

IBS treatment
Improved IBS symptoms
Reduced visceral hypersensitivity
Modest effects
Needs further research
Potential for side effects

This study investigates the effect of a multispecies probiotic on pain sensitivity in people with irritable bowel syndrome (IBS), a condition with varying causes and limited treatment options. The study focuses on those with increased sensitivity in the bowels, which is often linked to more severe symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Therapeutic effects, tolerability and safety of a multi-strain probiotic in Iranian adults with irritable bowel syndrome and bloating.

Author: JafariElham, VahediHomayoon, MeratShahin, MomtahenShabnam, RiahiAina

Probiotics efficacy
Symptom relief

A 4-week period of treatment with a combination of probiotics twice daily was safe, well tolerated, and effective in Iranian adults with irritable bowel syndrome (IBS) with abdominal bloating. The probiotic group reported satisfactory relief of general symptoms in 85% of patients compared with 47% in the control group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

The effects of cognitive behavioral therapy in female nursing students with irritable bowel syndrome: a randomized trial.

Author: JangAe Lee, HwangSun-Kyung, KimDong Uk

Improved IBS quality of life
Improved bowel symptoms

Cognitive behavioral therapy (CBT) was effective in improving clinical states of irritable bowel syndrome (IBS) in young female nursing students.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Intervention to increase physical activity in irritable bowel syndrome shows long-term positive effects.

Author: JohannessonElisabet, RingströmGisela, AbrahamssonHasse, SadikRiadh

Improved IBS
Improved quality of life

This study found that an intervention to increase physical activity in patients with irritable bowel syndrome (IBS) had positive long-term effects on IBS symptoms and psychological symptoms. The participants reported improved IBS symptoms, quality of life, fatigue, depression, and anxiety after 5.2 years of follow-up. The reported time of physical activity during the week before the visit had increased from 3.2 h at baseline to 5.2 h at follow-up.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Therapeutic effects of Lactobacillus in treating irritable bowel syndrome: a meta-analysis.

Author: TiequnBian, GuanqunChao, ShuoZhang

Clinical improvement
None reported

This meta-analysis systematically evaluated the effect of Lactobacillus in treating irritable bowel syndrome (IBS). Six randomized, placebo-controlled trials showed a significantly higher rate of treatment responders with Lactobacillus compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

21.

Effect of Yoga in the Therapy of Irritable Bowel Syndrome: A Systematic Review.

Author: SchumannDania, AnheyerDennis, LaucheRomy, DobosGustav, LanghorstJost, CramerHolger

IBS symptom reduction
Improved quality of life
Reduced anxiety

Yoga might be a feasible and safe adjunctive treatment for irritable bowel syndrome, with significant reductions in bowel symptoms, IBS severity, and anxiety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

A Diet Low in FODMAPs Reduces Symptoms in Patients With Irritable Bowel Syndrome and A Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial.

Author: StaudacherHeidi Maria, LomerMiranda C E, FarquharsonFreda M, LouisPetra, FavaFrancesca, FranciosiElena, ScholzMatthias, TuohyKieran M, LindsayJames O, IrvingPeter M, WhelanKevin

Low FODMAP diet for IBS
Microbiota changes

A low FODMAP diet associates with adequate symptom relief and significantly reduced symptom scores compared with placebo in patients with irritable bowel syndrome (IBS). Co-administration of a multistrain probiotic increased numbers of Bifidobacterium species, compared with placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

The effect of a multispecies probiotic on microbiota composition in a clinical trial of patients with diarrhea-predominant irritable bowel syndrome.

Author: HodKeren, DekelRoy, Aviv CohenNathaniel, SperberAmi, RonYishai, BoazMona, BerlinerShlomo, MaharshakNitsan

IBS treatment
Improved gut health
Multispecies probiotic
Potential for IBS-D relief
Needs further research
Unclear mechanism

This study investigates how a multi-strain probiotic affects gut bacteria in women with diarrhea-predominant irritable bowel syndrome (IBS-D). The study aims to determine if changes in gut bacteria are linked to improvements in IBS symptoms or markers of inflammation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Vortioxetine effects on quality of life of irritable bowel syndrome patients: A randomized, double-blind, placebo-controlled trial.

Author: SeddighniaAzadeh, Tadayon NajafabadiBorna, GhamariKiandokht, NoorbalaAhmad Ali, Ebrahimi DaryaniNaser, KashaniLadan, AkhondzadehShahin

Improved quality of life
Reduced IBS symptoms

Vortioxetine was superior to placebo in increasing quality of life in patients with irritable bowel syndrome (IBS).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

Comparison between the Effects of Acupuncture Relative to Other Controls on Irritable Bowel Syndrome: A Meta-Analysis.

Author: ZhengHaizhen, ChenRixin, ZhaoXiaofeng, LiGuanhui, LiangYi, ZhangHao, ChiZhenhai

Acupuncture for IBS

Acupuncture showed no superiority over sham acupuncture for treating irritable bowel syndrome (IBS), but it had a significant advantage over western medicine. The meta-analysis included 41 randomized controlled trials (RCTs) with 3440 participants. Future high-quality and large-sample-size studies are needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

28.

Efficacy of opioid receptor modulators in patients with irritable bowel syndrome: A systematic review and meta-analysis.

Author: LiXia, LiBo, ZhangJiaqi, ChenTing, WuHaomeng, ShiXiaoshuang, MaJinxin, QinJinyan, TangXudong, WangFengyun

IBS treatment
Potential for IBS symptom relief
Needs further research
Unclear effects of opioid modulators

This study aims to determine whether medications that affect opioid receptors in the body can help improve symptoms of irritable bowel syndrome (IBS). IBS is a common digestive disorder that can significantly impact people's lives, and this study seeks to find potential treatments by examining the role of opioid receptors in gut function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Randomised controlled trial: effects of gluten-free diet on symptoms and the gut microenvironment in irritable bowel syndrome.

Author: AlgeraJoost P, MagnussonMaria K, ÖhmanLena, StörsrudStine, SimrénMagnus, TörnblomHans

IBS symptom reduction

This study investigated the effects of a gluten-free diet in patients with irritable bowel syndrome (IBS). The gluten-free diet improved IBS symptoms, particularly bowel habits, in some patients. The study also identified distinct metabolite profiles in patients who responded to the gluten-free diet, suggesting that the diet influences the gut microbiome.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Low FODMAP diet reduces gastrointestinal symptoms in irritable bowel syndrome and clinical response could be predicted by symptom severity: A randomized crossover trial.

Author: AlgeraJoost P, DemirDagsu, TörnblomHans, NybackaSanna, SimrénMagnus, StörsrudStine

IBS symptom relief
IBS treatment
Dietary restrictions
Needs further research
Unclear predictors

A low FODMAP diet reduced gastrointestinal symptoms and improved bowel habits in IBS patients compared to a moderate FODMAP diet. However, the low FODMAP diet was not effective for everyone. While the study did not identify specific predictors of response to the low FODMAP diet, it suggests that individual sensitivity to FODMAPs varies widely.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

The effect of melatonin on irritable bowel syndrome patients with and without sleep disorders: a randomized double-blinded placebo-controlled trial study.

Author: Faghih DinevariMasood, JafarzadehFarzaneh, Jabbaripour SarmadianAmirreza, AbbasianSamaneh, NikniazZeinab, RiaziAli

IBS symptom relief
IBS treatment
Improved quality of life
Potential sleep improvement
Further research needed
Limited study findings

IBS is a common digestive problem with limited treatment options. This study examines the potential benefits of melatonin, a hormone that regulates sleep, for IBS patients. The study looks at how melatonin impacts IBS symptoms, quality of life, and sleep patterns in both those with and without sleep disorders.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

32.

The Effect of Polyphenols, Minerals, Fibers, and Fruits on Irritable Bowel Syndrome: A Systematic Review.

Author: ChiarioniGiuseppe, PopaStefan Lucian, IsmaielAbdulrahman, PopCristina, DumitrascuDinu Iuliu, BrataVlad Dumitru, DuseTraian Adrian, InczeVictor, Surdea-BlagaTeodora

IBS symptom management
Improved well-being
Further research needed
No specific findings

Irritable bowel syndrome (IBS) is a common digestive disorder. This review examines how different types of foods, including polyphenols (found in fruits, vegetables, and tea), minerals, fiber, and whole fruits, might affect IBS symptoms and overall health.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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