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Effect of oral felodipine on ocular circulation.

Author: DupontJ, GrunwaldJ E, SchocketL S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Felodipine, a calcium channel blocker, did not significantly affect retinal, optic nerve rim, or foveolar choroidal blood flow in healthy volunteers. The study involved 10 volunteers who received placebo or felodipine in a double-blind, randomized, crossover design. This suggests that felodipine may be a safe treatment option for systemic hypertension in patients with glaucoma.
Paper Details　
Original Abstract of the Article :
PURPOSE: To evaluate the effects of felodipine, a calcium channel blocker, on ocular circulation. METHODS: In a double blind, randomized, crossover design, 10 volunteers received placebo or felodipine on 2 separate days. Bidirectional laser Doppler velocimetry (BLDV), laser Doppler flowmetry (LDF),...See full text at original site
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引用元：
https://doi.org/10.1023/a:1026585515630

データ提供：米国国立医学図書館（NLM）

Felodipine: A Calcium Channel Blocker's Effect on Ocular Circulation

This research investigates the effects of felodipine, a calcium channel blocker commonly used to treat hypertension, on ocular circulation. The authors conducted a double-blind, randomized, crossover study involving 10 volunteers. They measured retinal, choroidal, and optic nerve rim circulatory parameters using various techniques, including laser Doppler velocimetry, laser Doppler flowmetry, and fundus photography. The study found that felodipine significantly reduced diastolic and mean blood pressure but did not significantly affect ocular blood flow.

Felodipine: A Potential Option for Hypertensive Patients with Glaucoma

The study found that felodipine effectively reduced blood pressure without causing significant changes in ocular blood flow. This finding is encouraging for hypertensive patients with glaucoma, as it suggests that felodipine may be a safe and effective treatment option for managing their blood pressure without exacerbating their glaucoma. The study highlights the importance of considering the impact of medications on ocular circulation, particularly in patients with glaucoma.

Managing Blood Pressure: A Balancing Act

This study highlights the importance of considering the impact of medications on ocular circulation, especially in patients with glaucoma. The authors suggest that felodipine may be a suitable option for hypertensive patients with glaucoma, offering blood pressure control without significantly affecting ocular blood flow. Just as a camel adapts to the challenges of desert life, healthcare professionals must carefully navigate the complexities of managing blood pressure in patients with glaucoma, seeking treatments that effectively control blood pressure without compromising eye health.

Dr.Camel's Conclusion

This study provides valuable insights into the effects of felodipine on ocular circulation. The findings suggest that felodipine may be a safe and effective treatment option for hypertensive patients with glaucoma, offering blood pressure control without significantly impacting ocular blood flow. The study highlights the importance of considering the impact of medications on ocular circulation in patients with glaucoma, ensuring that treatment decisions are made with careful consideration of the potential benefits and risks.

Date :
  1. Date Completed 2001-03-22
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

11196124

DOI: Digital Object Identifier

10.1023/a:1026585515630

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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