Effects of iron supplements on the oral bioavailability of moxifloxacin, a novel 8-methoxyfluoroquinolone, in humans.

Author: KubitzaD, StassH

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To investigate the effect of concomitant iron administration on the pharmacokinetics and tolerability of moxifloxacin. DESIGN: This was a single-centre, nonblinded, randomised, 2-way crossover study in healthy male volunteers. PARTICIPANTS: 12 healthy males (age 19 to 41 years) were enr...See full text at original site
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引用元:
https://doi.org/10.2165/00003088-200140001-00008

データ提供:米国国立医学図書館(NLM)

Iron Supplements and Moxifloxacin Bioavailability

The field of drug interactions is crucial for optimizing patient care and ensuring therapeutic efficacy. This research explores the impact of iron supplementation on the bioavailability of moxifloxacin, a commonly prescribed antibiotic. The researchers conducted a clinical trial to investigate how the simultaneous administration of iron supplements affects the absorption and efficacy of moxifloxacin. They found that iron supplements significantly reduced the bioavailability of moxifloxacin, suggesting a potential interaction between these two substances.

Impact of Iron on Drug Absorption

The study’s results demonstrate a notable interaction between iron supplements and moxifloxacin. This finding provides valuable insights into the potential for drug interactions, highlighting the need for careful consideration when prescribing multiple medications. Iron supplements can interfere with the absorption of moxifloxacin, potentially reducing its effectiveness. The authors suggest that staggered administration of these two substances may be necessary to minimize this interaction.

Understanding Drug Interactions

This research emphasizes the significance of understanding drug interactions, especially when patients are taking multiple medications. The findings underscore the importance of comprehensive patient assessments and medication reviews to identify potential drug interactions that could affect treatment outcomes.

Dr.Camel's Conclusion

Just like in the desert, where unexpected sandstorms can disrupt travel plans, drug interactions can unexpectedly alter the effectiveness of medications. This research reminds us of the importance of navigating the landscape of drug interactions with caution, ensuring that medications work in harmony rather than colliding like sand dunes.
Date :
  1. Date Completed 2001-09-20
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

11352443

DOI: Digital Object Identifier

10.2165/00003088-200140001-00008

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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