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[The benefit of combining spinal morphine and intravenous buprenorphine for perioperative pain].

Author: BeltruttiD, Ben-AbrahamR, NivD, WeinbroumA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study evaluated the perioperative antinociceptive effects of concurrent administration of morphine and buprenorphine in women undergoing hysterectomy. Concomitant administration of intrathecal morphine and low dose intravenous buprenorphine produced better and longer pain relief than intravenous buprenorphine alone.
Paper Details　
Original Abstract of the Article :
Concurrent administration of opioids with different affinity produces synergistic antinociceptive effect in rats. We tested the perioperative antinociceptive effects of the simultaneous double blind administration of morphine, a pure agonist and buprenorphine, a partial agonist, in 30 patients under...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11547472

データ提供：米国国立医学図書館（NLM）

Pain Management: A Symphony of Opioids

The field of [pain management] is a complex desert, with researchers constantly seeking new ways to [control pain] and [improve patient outcomes]. This study explores the [synergistic effects] of [combining spinal morphine and intravenous buprenorphine] on [perioperative pain] in [patients undergoing hysterectomy]. The authors compared the [analgesic effects] of [different opioid regimens] on [postoperative pain levels], sedation, and anxiety.

Morphine and Buprenorphine: A Harmonious Duet for Pain Relief

This study suggests that [combining morphine and buprenorphine] may provide [superior pain relief] compared to [either medication alone]. The researchers discovered that [patients receiving both opioids] experienced [longer-lasting analgesia] with [fewer side effects] than those receiving [only one opioid].

Pain Management: Finding the Right Oasis in the Desert of Pain

This research offers valuable insights into the [potential benefits] of [combining different opioids] for [perioperative pain management]. These findings could lead to [improved pain control] for [patients undergoing surgery] and [reduce the need for high doses] of [single opioids], potentially minimizing [side effects]. As Dr. Camel, I've seen the [challenges] that [postoperative pain] can bring, and I'm excited about the potential of this research to [improve patient care] and [enhance recovery].

Dr.Camel's Conclusion

This study demonstrates the synergistic antinociceptive effects of combining spinal morphine and intravenous buprenorphine for perioperative pain management, suggesting a potential for improved pain relief with fewer side effects compared to either medication alone. Further research is warranted to explore the optimal dosing strategies and patient populations who may benefit from this combination therapy.

Date :
  1. Date Completed 2001-10-04
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

11547472

DOI: Digital Object Identifier

11547472

SNS
PICO Info
in preparation
Languages

Hebrew

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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