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A randomized, double-blind, multicenter trial of nimesulide-beta-cyclodextrin versus naproxen in patients with osteoarthritis.

Author: BisognoStefania, Di MartinoStefania, FioravantiAntonella, MarcolongoRoberto, OldaniVirginio, ScottiAurelio, StorriLara

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Nimesulide-beta-cyclodextrin provides similar pain relief to naproxen in the management of OA of the hip and/or knee and is associated with fewer gastrointestinal adverse reactions.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Nonsteroidal anti-inflammatory drugs are the most widely used agents in the symptomatic treatment of osteoarthritis (OA). No data are presently available on the medium-term management of this disease with an on-demand treatment regimen, which nevertheless reflects medical practice. OBJE...See full text at original site
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引用元：
https://doi.org/10.1016/s0149-2918(02)85127-x

データ提供：米国国立医学図書館（NLM）

Nimesulide-beta-cyclodextrin vs. Naproxen: A Comparative Analysis of Osteoarthritis Pain Relief

In the field of [rheumatology], the management of [osteoarthritis (OA)] remains a significant challenge. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to alleviate pain and inflammation associated with OA, but their long-term effects and tolerability can vary. This study compares the efficacy and safety of [nimesulide-beta-cyclodextrin] and [naproxen] in managing OA pain, using both scheduled and on-demand dosing regimens.

Nimesulide-beta-cyclodextrin: A Potential Advantage in Gastrointestinal Tolerability

The study's results show that both medications effectively reduce OA pain, providing comparable relief in the short term. However, in terms of long-term management, nimesulide-beta-cyclodextrin emerges as a potential winner. The study found that nimesulide-beta-cyclodextrin was associated with a significantly lower incidence of [gastrointestinal intolerance] compared to naproxen, suggesting a potential advantage for patients who experience digestive discomfort with NSAIDs.

Navigating the Landscape of Pain Management: Choosing the Right NSAID

This study provides valuable insights for clinicians managing OA pain. The research suggests that nimesulide-beta-cyclodextrin may offer a more tolerable option for patients who experience gastrointestinal side effects with naproxen. However, individual patient factors should be considered, and careful monitoring for potential adverse effects is crucial.

Dr.Camel's Conclusion

Just as a camel's resilient body adapts to the harsh desert environment, NSAIDs can provide relief from the pain and inflammation associated with OA. This research offers a valuable guide for navigating the complex world of pain management, highlighting the potential benefits of nimesulide-beta-cyclodextrin for patients seeking a more tolerable treatment option.

Date :
  1. Date Completed 2002-11-05
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

12017396

DOI: Digital Object Identifier

10.1016/s0149-2918(02)85127-x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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