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Effect of neoadjuvant treatment with anastrozole on tumour histology in postmenopausal women with large operable breast cancer.

Author: AndersonT J, DixonJ M, MillerW R, SahmoudT, StuartM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Anastrozole, a non-steroidal aromatase inhibitor, has been shown to be effective as neoadjuvant treatment for breast cancer. This study evaluated the histological changes in breast tumors after neoadjuvant anastrozole treatment. The study found that anastrozole treatment had marked effects on tumor histopathology, but these did not always correlate with clinical response.
Paper Details　
Original Abstract of the Article :
Anastrozole is an orally active, non-steroidal aromatase inhibitor which appears effective as neoadjuvant treatment of breast cancer. Histological changes have been evaluated in biopsies from large, oestrogen-receptor rich, operable breast tumours in postmenopausal women following 12 weeks of neoadj...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364231/

データ提供：米国国立医学図書館（NLM）

Anastrozole's Impact on Breast Cancer: A Glimpse into the Desert's Shifting Sands

This study delves into the potential of anastrozole, an aromatase inhibitor, as a neoadjuvant treatment for large, estrogen-receptor-rich, operable breast tumors in postmenopausal women. The researchers investigated the histological changes in tumor biopsies after 12 weeks of treatment with anastrozole. The study aimed to understand the impact of anastrozole on tumor morphology and its correlation with clinical response.

What Does this Study Suggest?

The findings reveal that neoadjuvant anastrozole treatment has significant effects on tumor histopathology, although these changes don't always correlate with clinical response. It's like observing shifting sand dunes; the underlying structure may change, but the visible landscape may not always reflect the full extent of the transformation.

Implications for Health and Lifestyle

This study highlights the need for further research on the mechanisms of action of anastrozole and its role in the treatment of breast cancer. It emphasizes the importance of individualized treatment approaches, considering both histological and clinical responses.

Dr.Camel's Conclusion

This research underscores the complex nature of cancer treatment, where the desert landscape is constantly shifting. It's a reminder that we need to continue exploring new treatment strategies and refining our understanding of cancer biology.

Date :
  1. Date Completed 2002-09-10
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

12177804

DOI: Digital Object Identifier

PMC2364231

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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