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Treatment of early RA in clinical practice: a comparative study of two different DMARD/corticosteroid options.

Author: AhlménM, ForslindK, SvenssonB

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Patients who did not complete their first DMARD/CS treatment option had a reduced rate of individual response and remission. Treatment failures were more frequent in the sulfasalazine plus optional CS group than in the CS plus optional methotrexate treatment group.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To study the outcome in clinical practice of first DMARD and/or corticosteroid (CS) treatment in patients with recent onset rheumatoid arthritis (RA). PATIENTS: 245 patients with active RA, not previously treated with DMARDs or CS, were randomised to one of two treatment groups, T1 = 7....See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12846051

データ提供：米国国立医学図書館（NLM）

Early Rheumatoid Arthritis Treatment: A Comparative Study

This research examines the effectiveness of two different treatment options for patients with recently diagnosed rheumatoid arthritis (RA), exploring the best approach to manage this chronic inflammatory condition. It's like comparing different strategies for maintaining a flourishing oasis in a desert, seeking the most effective way to manage resources and prevent deterioration.

CS plus Optional Methotrexate: Better Outcomes

The study found that patients receiving a combination of corticosteroids (CS) and optional methotrexate (MTX) achieved better individual response and remission rates compared to those receiving sulfasalazine and optional CS. It's like finding that a combination of different desert plants, each with specific beneficial properties, offers a more effective solution than using a single plant.

Importance of Treatment Completion

The study also highlighted the importance of treatment completion for achieving positive outcomes. It's like recognizing that a desert oasis requires consistent care and management to thrive. Patients who did not complete their allocated treatment plan experienced lower response rates and a greater likelihood of remission.

Dr.Camel's Conclusion

This research, like a map guiding travelers through a challenging desert landscape, offers valuable insights into the management of early rheumatoid arthritis. It emphasizes the importance of choosing effective treatment options and ensuring consistent adherence to achieve the best possible outcomes for patients.

Date :
  1. Date Completed 2003-10-02
  2. Date Revised 2017-01-12
Further Info :

Pubmed ID

12846051

DOI: Digital Object Identifier

12846051

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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