Paper Details

  1. Home
  2. Paper Details

A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group.

Author: CollinsJ F, CramerJ A, MattsonR H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Valproate is effective in treating various seizure types, including partial and secondary generalized tonic-clonic seizures, which are often difficult to control with standard treatments.
Paper Details　
Original Abstract of the Article :
Valproate is approved for use primarily in patients with absence seizures, but the drug has a broad spectrum of activity against seizures of all types. Partial or secondarily generalized tonic-clonic seizures are often difficult to control adequately with standard treatment, usually carbamazepine or...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1056/NEJM199209103271104

データ提供：米国国立医学図書館（NLM）

Valproate vs. Carbamazepine: A Tale of Two Anti-Seizure Medications

The world of epilepsy treatment is a fascinating one, much like a camel navigating the vast and challenging desert. This study investigates the effectiveness of valproate and carbamazepine in treating complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The study found that valproate was comparable to carbamazepine in controlling seizures in this patient population, demonstrating the potential for valproate as an alternative treatment option for complex seizure types.

Valproate: A Promising Alternative for Epilepsy Treatment

The study's findings suggest that valproate can be a viable alternative to carbamazepine in the management of complex partial seizures and secondarily generalized tonic-clonic seizures. This is significant because valproate has a broader spectrum of anti-seizure activity, potentially providing more comprehensive seizure control. This discovery is like finding a new oasis in the desert, offering a potential solution for those struggling with epilepsy.

Navigating the Choices in Epilepsy Management

The study highlights the importance of individualized treatment approaches in epilepsy management. The choice of anti-seizure medication should be carefully considered based on the individual patient's needs, seizure type, and potential side effects. Just as a camel adapts its strategy based on the terrain, doctors need to tailor their treatment approach to each patient's unique situation. This research contributes to our understanding of epilepsy treatment options, providing valuable information for clinicians and patients alike.

Dr. Camel's Conclusion

This study provides valuable insights into the efficacy of valproate as a treatment option for complex seizure types. Just as a camel navigates the desert with a keen eye for the best routes, we must thoughtfully consider the diverse treatment options available for epilepsy. This research is a testament to the ongoing quest for more effective and personalized treatments for individuals living with epilepsy.

Date :
  1. Date Completed 1992-09-14
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

1298221

DOI: Digital Object Identifier

10.1056/NEJM199209103271104

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.