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A randomized trial comparing the use of fresh and stored platelets in the treatment of bone marrow transplant recipients.

Author: AschanJ, LarssonS, RingdénO, ShanwellA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 39 patients undergoing bone marrow transplantation compared the effectiveness of using fresh versus stored single-donor platelet concentrates (PC). The study found no significant difference in the total platelet requirement, platelet count increase at 1 hour, or platelet count increase at 18 hours between the groups. The study concluded that there is no major difference in effectiveness between fresh and stored single-donor platelets.
Paper Details　
Original Abstract of the Article :
Patients undergoing allogeneic bone marrow transplantation (BMT) were randomized into two groups. One group (n = 21) received single donor platelet concentrates (PC) that were as fresh as possible, the other group (n = 18) received single donor PC stored for 2 to 5 days. Actual mean storage times fo...See full text at original site
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引用元：
https://doi.org/10.1111/j.1600-0609.1992.tb00035.x

データ提供：米国国立医学図書館（NLM）

A Randomized Trial Comparing Fresh and Stored Platelets in Bone Marrow Transplant Recipients

This study compared the use of fresh and stored platelets in the treatment of bone marrow transplant recipients. The researchers randomly assigned 39 patients undergoing allogeneic bone marrow transplantation into two groups: one group received fresh platelet concentrates (PC) and the other received single donor PC stored for 2 to 5 days. They assessed the total need for platelets, posttransfusion corrected count increment (CCI) at 1 hour and 18 hours, and overall platelet requirement during the 60 days following transplantation.

Fresh vs. Stored Platelets: No Significant Difference in Efficacy

The study found no major difference in the efficacy of fresh and stored single donor PC. The platelet requirement and CCI at 1 hour and 18 hours were similar between the two groups. This suggests that stored platelets can be used effectively in the treatment of bone marrow transplant recipients, offering a practical and potentially cost-effective option.

The Gift of Life: Fresh or Stored?

Think of platelets as tiny, life-giving messengers, traveling through the bloodstream to help clot wounds and stop bleeding. In the context of bone marrow transplantation, these messengers are crucial for recovery. This study provides reassurance that stored platelets can be just as effective as fresh platelets in delivering these essential messages. Just like a camel can travel great distances carrying precious cargo, stored platelets can effectively deliver their life-giving properties, even after a journey through the desert of storage.

Dr.Camel's Conclusion

This randomized trial suggests that stored platelets can be used effectively in the treatment of bone marrow transplant recipients, offering a practical alternative to fresh platelets. The study's findings contribute to our understanding of platelet storage and can inform clinical decision-making in this critical area of healthcare.

Date :
  1. Date Completed 1992-11-25
  2. Date Revised 2019-09-07
Further Info :

Pubmed ID

1397244

DOI: Digital Object Identifier

10.1111/j.1600-0609.1992.tb00035.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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