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Lowering cholesterol: effects on trauma death, cancer death and total mortality.

Author: MacMahonS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A review of 26 studies involving 50,000 patients found that cholesterol reduction (about 10%) significantly reduced the risk of coronary heart disease (CHD) after just a few years of treatment. The reduction in CHD-related deaths was half the reduction in non-fatal heart attacks, but both were statistically significant. The overall reduction in total mortality fell within the expected range based on the reduction in CHD deaths. While there was a slight increase in cancer and trauma deaths among patients receiving cholesterol-lowering treatment, these increases were not statistically significant and were likely due to chance.
Paper Details　
Original Abstract of the Article :
Randomised trials of cholesterol reduction (26 trials, 50,000 patients, net cholesterol reduction approximately 10%) have demonstrated a clear reduction in the incidence of coronary heart disease (CHD) after just a few years of treatment. Overall, the reduction in CHD death was only half as large as...See full text at original site
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引用元：
https://doi.org/10.1111/j.1445-5994.1992.tb00481.x

データ提供：米国国立医学図書館（NLM）

Cholesterol Reduction and Mortality

The realm of cardiovascular health is constantly evolving as researchers seek to understand the complex interplay of factors that contribute to heart disease. This study examines the effects of cholesterol reduction on overall mortality, drawing on data from 26 randomized trials involving over 50,000 patients. The analysis showed that cholesterol reduction significantly reduced coronary heart disease (CHD) death, although a small increase in deaths from cancer and trauma was observed. However, these increases were not statistically significant, suggesting that they might have occurred by chance.

The Complexities of Cholesterol Reduction

This research highlights the complex relationship between cholesterol levels and overall mortality. While cholesterol reduction was associated with a significant decrease in CHD deaths, the study also observed a small, non-significant increase in deaths from other causes. This underscores the need for continued research to fully understand the potential long-term effects of cholesterol-lowering therapies.

Navigating Cholesterol Management

This study emphasizes the importance of considering the potential risks and benefits of cholesterol-lowering therapies. While these medications can effectively reduce the risk of CHD, it's crucial to weigh the potential for other adverse effects. The findings underscore the need for individualized care and informed decision-making in managing cholesterol levels.

Dr.Camel's Conclusion

Just as a camel navigates the desert's challenges, humans face a multitude of health risks. This research reminds us that even seemingly beneficial interventions, like cholesterol reduction, can have complex and sometimes unexpected consequences. It encourages us to approach healthcare decisions with a balanced perspective, weighing the potential benefits and risks, and seeking guidance from qualified healthcare professionals.

Date :
  1. Date Completed 1992-12-30
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

1449443

DOI: Digital Object Identifier

10.1111/j.1445-5994.1992.tb00481.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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