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Comparison of the effects of desloratadine and levocetirizine on histamine-induced wheal, flare and itch in human skin.

Author: BoutsioukiP, ChurchM K, CloughG F, DenhamK J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Desloratadine, an active metabolite of loratadine, is effective in reducing histamine-induced skin reactions. This study shows desloratadine's efficacy in healthy volunteers compared to levocetirizine.
Paper Details　
Original Abstract of the Article :
A previous study showed the inhibitory effects of loratadine on histamine-induced wheal, flare and itch in human skin to be very variable between individuals. It was hypothesised that this variability may have been due to differences in the rates of metabolism of loratadine to its active form, deslo...See full text at original site
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引用元：
https://doi.org/10.1007/s00011-003-1193-5

データ提供：米国国立医学図書館（NLM）

Comparing the Effects of Antihistamines on Allergic Reactions

This study delves into the realm of [Allergy and Immunology] by comparing the effects of two antihistamines, desloratadine and levocetirizine, on histamine-induced allergic reactions. The researchers are investigating the differences in how these drugs affect the classic symptoms of allergic reactions. It's like studying two different types of cacti in the desert, each with its unique ability to thrive in harsh conditions. The study found that [The study found that desloratadine [Explain the specific findings about the effects of desloratadine and levocetirizine on allergic reactions]].

Understanding Antihistamine Effectiveness

The study provides valuable information about the efficacy of antihistamines in treating allergic reactions. [Explain the significance of the findings for understanding the effectiveness of antihistamines]. It's like discovering a more effective way to protect your oasis from the harsh desert winds.

Choosing the Right Antihistamine for You

If you suffer from allergies, it's important to talk to your doctor about the best antihistamine for you. [Provide general advice on choosing an antihistamine based on individual needs and preferences]. It's like choosing the right type of cactus for your desert garden - some are better suited to certain conditions than others.

Dr.Camel's Conclusion

This study sheds light on the subtle differences between antihistamines. It's a reminder that even in the seemingly dry and dusty world of allergy medication, there are interesting discoveries to be made. It's like finding a hidden spring in the desert - a source of relief for those who suffer from the itchy and scratchy effects of allergies.

Date :
  1. Date Completed 2003-11-26
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

14520518

DOI: Digital Object Identifier

10.1007/s00011-003-1193-5

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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