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Amlodipine compared to nitrendipine in hypertensive patients: the effects on toleration in relationship to the onset of action.

Author: BorgesE T, ChristelerP, Guillaume-GentilM, HollensteinU, MannhartM, WaeberB

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Amlodipine and nitrendipine, both calcium antagonists, are effective in lowering blood pressure in patients with mild to moderate essential hypertension. While they are therapeutically equivalent, amlodipine has a slower onset of action, resulting in fewer acute side effects and potentially better patient compliance.
Paper Details　
Original Abstract of the Article :
Amlodipine and nitrendipine are calcium antagonists of the 1,4-dihydropyridine group which differ in their pharmacokinetic and pharmacodynamic properties. The clinical relevance of these differences was investigated in a study designed to compare the efficacy and safety of once-daily amlodipine (5 m...See full text at original site
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引用元：
https://doi.org/10.1159/000175047

データ提供：米国国立医学図書館（NLM）

Amlodipine vs. Nitrendipine: A Tale of Two Calcium Antagonists

This study delves into the world of calcium antagonists, comparing the efficacy and tolerability of amlodipine and nitrendipine in treating hypertension. The researchers found that both drugs effectively lowered blood pressure, but with distinct onset times and side effect profiles. Amlodipine's gradual onset of action was associated with fewer initial side effects, suggesting potential advantages for patients starting treatment.

Amlodipine: A Gradual Approach to Lowering Blood Pressure

This study suggests that amlodipine may be a preferable option for some patients with hypertension, particularly those who are sensitive to sudden blood pressure drops or side effects. The drug's slower onset of action, while leading to a gradual reduction in blood pressure, may offer a more comfortable experience for patients.

Hypertension Management: A Personal Journey

This study highlights the importance of individualizing treatment approaches to hypertension. The researchers emphasize that not all calcium antagonists are created equal, and choosing the right medication for each patient is crucial. This research reminds us that effective healthcare is not a one-size-fits-all approach; it requires a personalized strategy to address the unique needs of each individual.

Dr. Camel's Conclusion

This study demonstrates that even within the realm of seemingly similar medications, there can be significant variations in their effects and side effect profiles. This research underscores the importance of tailoring treatment plans to the individual patient, ensuring the most effective and well-tolerated approach to managing hypertension.
Date :
  1. Date Completed 1992-07-15
  2. Date Revised 2018-02-15
Further Info :

Pubmed ID

1534715

DOI: Digital Object Identifier

10.1159/000175047

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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