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Lipid intervention trials in primary prevention: a critical review.

Author: KaplanN M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Six randomized trials demonstrated a significant reduction in coronary heart disease morbidity and mortality, but not overall mortality due to increased cancer and violent deaths in the treated group. These adverse effects may not be directly related to cholesterol reduction but cannot be disregarded. Caution is advised in advocating widespread treatment for even mild hypercholesterolemia due to limited benefits and high costs.
Paper Details　
Original Abstract of the Article :
On the basis of six randomized primary intervention trials, major changes in the diagnosis and treatment of relatively mild hypercholesterolemia have been strongly advocated. This paper examines the data from these six trials which show a significant reduction in morbidity and mortality from coronar...See full text at original site
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引用元：
https://doi.org/10.3109/10641969209036175

データ提供：米国国立医学図書館（NLM）

The Cholesterol Conundrum: A Critical Review of Lipid Intervention Trials

In this research, the authors take a critical look at [lipid intervention trials] in the context of [primary prevention]. They journey through the data of six randomized trials, seeking to shed light on the effectiveness of [cholesterol-lowering drugs] in preventing [coronary heart disease]. This study is a testament to the need for rigorous evaluation in the medical field, particularly when considering interventions with potential side effects.

Balancing Benefits and Risks: A Deeper Look at Cholesterol Intervention

The researchers found that while these trials showed a reduction in [coronary heart disease morbidity and mortality], they also revealed a potential increase in [cancer and violent deaths] in the treatment group. This finding highlights the complexity of evaluating medical interventions and the need to weigh potential benefits against potential risks. While the researchers couldn't definitively link these adverse effects to the cholesterol-lowering drugs, they emphasize the need for caution when prescribing these medications.

A Cautious Approach: Considerations for Cholesterol Management

This research serves as a reminder that even seemingly beneficial interventions can have unforeseen consequences. While lowering cholesterol levels may be beneficial in reducing heart disease risk, it's crucial to consider the potential impact on other health outcomes. This research encourages a more balanced approach to [cholesterol management], emphasizing the importance of individualized care and careful consideration of both risks and benefits.

Dr.Camel's Conclusion

This study reminds us that the desert of medical research is vast and complex. Just as a mirage can deceive a thirsty traveler, the benefits of cholesterol-lowering drugs need to be carefully assessed against potential risks. The researchers call for caution in the widespread use of these medications, urging us to consider a more nuanced approach to cholesterol management. This study is a valuable reminder to always seek a balanced perspective when navigating the challenges of medical interventions.

Date :
  1. Date Completed 1992-04-09
  2. Date Revised 2019-09-18
Further Info :

Pubmed ID

1541031

DOI: Digital Object Identifier

10.3109/10641969209036175

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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