High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study.

Author: , BeckerG, DenglerR, EckerD, EgerK, GerlachM, GrafM, HagerC, HechtM, HogeA, HorowskiR, JostW H, KostopulosP, KramerB, KrampflK, LubikS, LudolphA C, NeudeckerS, NeundörferB, OsterhageJ, PetriS, RiedererP, SchimkeN, SchraderC, SchrankB, SievertM, SteinC, TraufellerK, TroegerM, WekwerthK, WuerzA, ZierzS

Paper Details 
Original Abstract of the Article :
Increasing evidence has suggested that oxidative stress may be involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). The antioxidant vitamin E (alpha-tocopherol) has been shown to slow down the onset and progression of the paralysis in transgenic mice expressing a mutation in the supe...See full text at original site
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引用元:
https://doi.org/10.1007/s00702-004-0220-1

データ提供:米国国立医学図書館(NLM)

High-Dose Vitamin E for Amyotrophic Lateral Sclerosis: A Placebo-Controlled Trial

The field of [neurology] continues to explore the complex mechanisms of [amyotrophic lateral sclerosis (ALS)], a debilitating neurodegenerative disease. This research investigates the potential of [vitamin E] as an [add-on therapy] to [riluzole], a standard treatment for [ALS]. The researchers conducted a [double-blind, placebo-controlled, randomized clinical trial], a rigorous research design, to assess the efficacy of [high-dose vitamin E] in slowing disease progression. This research is like a desert expedition, where different strategies are tested to overcome the challenges of a harsh environment, in this case, the relentless progression of ALS.

High-Dose Vitamin E: No Significant Impact on Disease Progression

The results of this study are particularly relevant to [individuals with ALS] and their families. The researchers found that [high-dose vitamin E], while showing promise in [pre-clinical studies], did not significantly slow disease progression in [ALS patients]. This is like a desert traveler discovering that a seemingly promising oasis turns out to be a mirage. This research, while not yielding the hoped-for results, provides valuable insights into the complexities of [ALS] and the need for continued research into [effective treatments].

Navigating ALS: A Need for Continued Research

Individuals with [ALS] should work closely with their [neurologists] to discuss the [latest treatment options] and develop [personalized treatment plans]. This research highlights the importance of [continued research] into [effective treatments for ALS]. It's like a desert traveler constantly seeking new ways to navigate the challenges of the terrain. This study contributes to a better understanding of [ALS] and can guide future research efforts to improve [patient outcomes].

Dr.Camel's Conclusion

This study, like a desert expedition, reminds us that the search for effective treatments for ALS is an ongoing journey. While high-dose vitamin E may not be the answer, continued research and collaboration are essential for finding new pathways to combat this debilitating disease.

Date :
  1. Date Completed 2006-02-16
  2. Date Revised 2015-10-26
Further Info :

Pubmed ID

15517433

DOI: Digital Object Identifier

10.1007/s00702-004-0220-1

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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