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[Comparison of PVRV and HDCV rabies vaccines as to immunity, reliability and protective value].

Author: BarutA, EyigünC, HacibektaşoğluA, InalA, TürkayF A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

PVRV and HDCV vaccines for rabies were equally effective in inducing neutralizing antibodies in healthy male volunteers. Both vaccines provided a year-long protection until the first booster dose.
Paper Details　
Original Abstract of the Article :
World Health Organization (WHO) recommends a new Inactivated Rabies Vaccine grown on Vero Cells, (PVRV: Purified Vero Rabies Vaccine) with the vaccine cultivated on Human Diploid Cells (HDCV: Human Diploid Cell Vaccine), for both pre and post-exposure prophylaxis. Following the widespread use of HDC...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1574019

データ提供：米国国立医学図書館（NLM）

Comparing PVRV and HDCV Rabies Vaccines: A Race to the Finish Line

The world of immunology is a fascinating one, where scientists are constantly striving to find the best ways to protect us from diseases. This study focuses on the battle between two types of rabies vaccines, PVRV and HDCV. Both vaccines are recommended by the World Health Organization (WHO) for both pre and post-exposure prophylaxis. The researchers in this study used a double-blind method, where 90 volunteers were randomly assigned to receive either PVRV, HDCV, or a placebo. The study found that both vaccines were effective in producing neutralizing antibodies, suggesting that they both provide similar levels of protection. This research is essential for understanding the effectiveness of different rabies vaccines and ensuring that people are protected from this potentially deadly disease.

Are Both Vaccines Equally Effective?

The results showed that both PVRV and HDCV groups had similar levels of neutralizing antibodies on day 21, with no statistically significant difference. However, on the 60th day, both vaccines showed higher antibody titers, indicating a longer-lasting protective effect.

Choosing the Right Vaccine: A Decision for the Desert Traveler

Both vaccines appear to offer a year-long protection against rabies. This is a valuable piece of information, particularly for those travelling to regions where rabies is prevalent. It's important to remember that these are just preliminary findings and further studies are needed to confirm the long-term effectiveness of these vaccines.

Dr.Camel's Conclusion

This study reveals that the race to the finish line for rabies protection is a close one. Both PVRV and HDCV vaccines appear to be equally effective, offering a year of protection against this potentially deadly disease. This information is crucial for those traversing the vast deserts of the world, where rabies is a real threat. However, like a mirage in the desert, more research is needed to ensure these findings are solid and unwavering.

Date :
  1. Date Completed 1992-06-01
  2. Date Revised 2006-11-15
Further Info :

Pubmed ID

1574019

DOI: Digital Object Identifier

1574019

SNS
PICO Info
in preparation
Languages

Turkish

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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