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Inhibition of inflammatory and bone-resorption-inhibitory effects of alendronate by etidronate.

Author: EndoY, FunayamaH, MayanagiH, MonmaY, OhsakoM, SugawaraS

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of aminobisphosphonates (aminoBPs) and nonaminobisphosphonates (nonaminoBPs) on bone resorption and inflammation in mice. The study found that clodronate, a non-aminoBP, inhibited the inflammatory effects of aminoBPs while preserving their bone-resorption-inhibitory activities. Etidronate, another non-aminoBP, inhibited both the inflammatory effects and bone-resorption-inhibitory activities of aminoBPs. This suggests that clodronate may be a more effective strategy for reducing the inflammatory side effects of aminoBPs while maintaining their therapeutic benefits.
Paper Details　
Original Abstract of the Article :
Among the bisphosphonates (BPs), the aminobisphosphonates (aminoBPs) have much stronger bone-resorption-inhibitory activities (BRIAs) than nonaminobisphosphonates (nonaminoBPs). However, aminoBPs have inflammatory effects. We previously reported that in mice: (i) all aminoBPs tested (10-40 micromol/...See full text at original site
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引用元：
https://doi.org/10.1007/s00223-004-0180-3

データ提供：米国国立医学図書館（NLM）

Bisphosphonates: Navigating the Desert of Bone Metabolism

The field of Bone Metabolism is a complex and intricate landscape, where researchers seek to understand the delicate balance of bone formation and resorption. This study, published in the field of Pharmacology, investigates the effects of two bisphosphonates, alendronate and etidronate, on bone resorption and inflammation. The researchers explored the potential interactions between these two drugs, investigating the impact of etidronate on the inflammatory and bone-resorption-inhibitory effects of alendronate.

Etidronate: A Potential Modifier of Alendronate Effects

The study's findings suggest that etidronate can modulate the effects of alendronate on bone metabolism. Etidronate was found to inhibit the inflammatory actions of alendronate, reducing the induction of histidine decarboxylase, a marker of inflammation. However, etidronate also inhibited the bone-resorption-inhibitory effects of alendronate, potentially reducing its overall impact on bone metabolism.

Navigating the Desert of Bisphosphonate Treatment: Finding the Right Balance

The study's findings highlight the complex interactions between different bisphosphonates and the potential for these drugs to have both beneficial and detrimental effects on bone metabolism. The researchers' findings underscore the importance of careful consideration and appropriate dose management when utilizing bisphosphonates for the treatment of bone disorders.

Dr. Camel's Conclusion

This study, like a map guiding us through the intricate desert of bone metabolism, reveals the complex interactions between different bisphosphonates and the potential for these drugs to have both beneficial and detrimental effects on bone health. The researchers' findings highlight the importance of carefully considering the potential interactions between bisphosphonates and tailoring treatment strategies to the specific needs of individual patients.

Date :
  1. Date Completed 2005-09-15
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15895282

DOI: Digital Object Identifier

10.1007/s00223-004-0180-3

SNS
PICO Info
in preparation
Languages

English

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