Paper Details

  1. Home
  2. Paper Details

Comparative effects of anastrozole, tamoxifen alone and in combination on plasma lipids and bone-derived resorption during neoadjuvant therapy in the impact trial.

Author: , BanerjeeS, BarkerP, DowsettM, FolkerdL, IqbalJ, SmithI E

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Anastrozole did not have a detrimental effect on lipid profiles following 3 months of therapy. There was a significant increase in CTx with anastrozole in contrast to tamoxifen.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Estrogen has beneficial effects on lipid metabolism and bone preservation. The IMPACT trial evaluated neoadjuvant therapy with anastrozole or tamoxifen alone, or a combination. The comparative effects of these treatments on serum lipids and bone resorption were assessed. PATIENTS AND ME...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1093/annonc/mdi322

データ提供：米国国立医学図書館（NLM）

The IMPACT Trial: Navigating the Desert of Estrogen's Effects

The complex world of estrogen's effects on our bodies is like a vast, intricate desert landscape. This study, known as the IMPACT trial, investigated the comparative effects of anastrozole, tamoxifen, and their combination on lipid metabolism and bone resorption in postmenopausal women. It's like a scientific expedition carefully mapping the impact of these therapies on the body's delicate hormonal balance.

A New Perspective on Estrogen Therapy: Uncovering Nuances

The IMPACT trial findings are like a newly discovered oasis in the desert of estrogen therapy. The research revealed subtle differences in the effects of anastrozole and tamoxifen on lipid profiles and bone resorption. Anastrozole did not negatively affect lipid levels, but it did increase bone resorption. Tamoxifen, on the other hand, positively influenced lipid profiles but had a less pronounced effect on bone resorption. These nuanced findings provide valuable insights for clinicians, helping them make more informed decisions about estrogen therapy based on individual patient needs.

Guiding the Path: Optimizing Estrogen Therapy for Women

The desert of estrogen therapy can be challenging to navigate. This study offers guidance for clinicians, helping them understand the nuances of different estrogen therapies and tailor them to individual patients. By considering factors such as lipid profiles and bone resorption, clinicians can make more informed decisions that optimize patient outcomes. This research emphasizes the importance of personalized care and the need for ongoing research to understand the full range of estrogen's effects on the body.

Dr. Camel's Conclusion

The IMPACT trial is like a scientific expedition, meticulously mapping the effects of different estrogen therapies. It reveals the complex and often subtle ways these therapies affect the body. The study's findings offer valuable insights for clinicians, helping them make more informed decisions about estrogen therapy and optimize patient outcomes. This research is a testament to the ongoing pursuit of knowledge and the desire to improve women's health.

Date :
  1. Date Completed 2006-01-26
  2. Date Revised 2020-02-03
Further Info :

Pubmed ID

16030027

DOI: Digital Object Identifier

10.1093/annonc/mdi322

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.