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Antidepressants and their effect on sleep.

Author: BaldwinDavid S, MayersAndrew G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Antidepressants can affect sleep. The effect depends on the class of antidepressant used and the dosage. Insomnia is often seen with monoamine oxidase inhibitors (MAOIs), with all tricyclic antidepressants (TCAs) except amitriptyline, and all selective serotonin reuptake inhibitors (SSRIs) with venlafaxine and moclobemide as well. Sedation has been reported with all TCAs except desipramine, with mirtazapine and nefazodone, the TCA-related maprotiline, trazodone and mianserin, and with all MAOIs. REM sleep suppression has been observed with all TCAs except trimipramine, but especially clomipramine, with all MAOIs and SSRIs and with venlafaxine, trazodone and bupropion.
Paper Details　
Original Abstract of the Article :
Given the relationship between sleep and depression, there is inevitably going to be an effect of antidepressants on sleep. Current evidence suggests that this effect depends on the class of antidepressant used and the dosage. The extent of variation between the effects of antidepressants and sleep ...See full text at original site
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引用元：
https://doi.org/10.1002/hup.726

データ提供：米国国立医学図書館（NLM）

Antidepressants and the Labyrinth of Sleep

The complex relationship between [depression] and [sleep] is like a maze of interconnected pathways. This research delves into the impact of various antidepressants on sleep patterns, uncovering a nuanced interplay between these two fundamental aspects of our well-being. The authors explore how different classes of antidepressants, each with its unique mechanism of action, can influence our sleep.

Unraveling the Effects on Sleep

The authors systematically reviewed numerous randomized-controlled trials (RCTs) to understand the influence of antidepressants on sleep. The effects varied widely depending on the class of antidepressant and the dosage. Imagine a desert with different oases, each with its distinct properties - some oases are calming and induce sleep, while others are energizing and disrupt sleep. The research helps us navigate this desert of sleep patterns and understand the unique characteristics of each antidepressant.

Navigating the Sleepscape

The research provides valuable insights into the potential sleep disturbances associated with different antidepressants. Some classes, such as [monoamine oxidase inhibitors (MAOIs)], were associated with [insomnia]. Others, such as [tricyclic antidepressants (TCAs)], were linked to [sedation]. These insights can guide clinicians in choosing the most appropriate antidepressant for each patient, taking into account their individual sleep needs and preferences.

Dr.Camel's Conclusion

This research sheds light on the intricate connection between antidepressants and sleep. It's like navigating a vast desert of sleep, where each class of antidepressant has its own unique oasis, offering different effects on sleep patterns. Understanding these nuances is crucial for optimizing treatment plans and improving patient outcomes.

Date :
  1. Date Completed 2006-03-28
  2. Date Revised 2018-12-03
Further Info :

Pubmed ID

16229049

DOI: Digital Object Identifier

10.1002/hup.726

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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